公开(公告)号：US20120193574A1

公开(公告)日：2012-08-02

申请号：US13393523

申请日：2010-08-26

申请人： Sharon Jane Cooper ,  Catherine Emma Nicholson

发明人： Sharon Jane Cooper ,  Catherine Emma Nicholson

IPC分类号： C07C229/06 ,  C09K3/00 ,  C07C229/54

CPC分类号： B01D9/0004 ,  B01D9/00 ,  B01D9/0054

摘要： The invention provides a method of crystallising a compound comprising either: (i) providing a first confined solution comprising the compound; and adding more of the compound to and/or increasing the degree of saturation of the first confined solution, whereby to provide a resultant second confined solution that comprises more compound and/or that has a greater degree of supersaturation relative to a confined supersaturated solution of the same compound stabilised solely by being confined; or (ii) providing a first confined melt comprising the compound; and cooling and/or increasing the pressure of the first confined melt, whereby to provide a resultant second confined melt that is cooler and/or is more pressurised relative to a confined super-cooled melt of the same compound stabilised solely by being confined, whereby to effect the crystallising under confinement and under thermodynamic control.

摘要翻译： 本发明提供一种结晶化合物的方法，包括：（i）提供包含该化合物的第一限制溶液; 并且将更多的化合物加入到和/或增加第一限制溶液的饱和度，从而提供所得到的第二约束溶液，其包含更多的化合物和/或相对于约束过饱和溶液的过饱和溶液具有更大程度的过饱和度 相同的化合物仅通过限制而稳定; 或（ii）提供包含所述化合物的第一限制熔体; 并且冷却和/或增加第一限制熔体的压力，由此提供相对于仅通过限制稳定稳定的相同化合物的约束过冷却熔体而更冷和/或加压的所得第二约束熔体，由此 在限制和热力学控制下实现结晶。