公开(公告)号：US20090305967A1

公开(公告)日：2009-12-10

申请号：US12064012

申请日：2006-08-21

申请人： Shawn DeFrees ,  David A. Zopf ,  Susann Taudte ,  Walter S. Willett ,  Mattew Kalo ,  Robert J. Bayer

发明人： Shawn DeFrees ,  David A. Zopf ,  Susann Taudte ,  Walter S. Willett ,  Mattew Kalo ,  Robert J. Bayer

IPC分类号： A61K38/36 ,  C12P21/02 ,  A61P7/04

CPC分类号： C07K14/745 ,  A61K47/549 ,  A61K47/60

摘要： The present invention provides conjugates between Factor VII or Factor VIIa peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

摘要翻译： 本发明提供因子VII或因子VIIa肽和PEG部分之间的缀合物。 缀合物经由完整的糖基连接基团连接，该基团介于并共价连接到肽和修饰基团之间。 通过糖基转移酶的作用，缀合物由糖基化和未糖基化的肽形成。 糖基转移酶将修饰的糖部分连接到肽上的氨基酸或糖基残基上。 还提供了包括缀合物的药物制剂。 缀合物的制备方法也在本发明的范围内。