公开(公告)号：US20140296496A1

公开(公告)日：2014-10-02

申请号：US14355535

申请日：2012-11-01

申请人： Shenyang Kesi High-Technology Co. Ltd.

发明人： Jinsong Zhang ,  Mingtian Li ,  Zhiyu Liu ,  Lei Xu

IPC分类号： C08B37/00

CPC分类号： C08B37/0084 ,  C08B37/0003 ,  C08L5/04

摘要： This invention relates to an extraction process of brown algae polysaccharides in a field of pharmaceutical chemistry. This invention particularly discloses a process of extracting brown algae polysaccharides based on a microwave chemistry method and brown algae polysaccharides obtained by said process. The process of the invention comprises: 1) putting pulverized brown algae powder into a microwave reaction chamber, adding acid solution to conduct reaction; optionally concentrating the mixer, and then washing with organic solvent to remove excess acid; conducting grading alcohol precipitation after water extract to obtain mannuronic acid rich fragment (M rich) algin, fucoidan and/or laminaran respectively; and adding an alkali solution to the brown algae residue to conduct alkaline digestion, filtering the residue off, adjusting pH of the filtrate to neutral, conducting alcohol precipitation to obtain guluronic acid rich fragment (G rich) algin precipitates. The present invention has significant advantages like fast processing rate, high yield of polysaccharides, strong controllable polysaccharide degradation, using less organic acid and efficient recovery, small water consumption, low power consumption, etc., the active polysaccharides has high yield and content, better water-soluble, and good biological activities.

摘要翻译： 本发明涉及药物化学领域中褐藻多糖的提取方法。 本发明特别公开了一种基于微波化学方法提取褐藻多糖的方法和通过所述方法获得的褐藻多糖。 本发明的方法包括：1）将粉碎的褐藻粉放入微波反应室中，加酸溶液进行反应; 任选地浓缩混合器，然后用有机溶剂洗涤以除去过量的酸; 在水提取物后进行分级酒精沉淀，分别得到富含甘露糖醛酸的片段（富M），藻酸盐和/或层流蛋白; 并向棕色藻类残渣中加入碱溶液进行碱性消化，过滤残余物，调节滤液pH至中性，进行酒精沉淀，得到富含富罗勒浓的片段（富G）藻酸盐沉淀物。 本发明具有加工速度快，多糖收率高，多糖降解可靠，有机酸少，有效回收，耗水量少，功耗低等优点，活性多糖具有较高的产量和含量，较好的 水溶性好，生物活性好。

公开(公告)号：US09447198B2

公开(公告)日：2016-09-20

申请号：US14355531

申请日：2012-11-01

申请人： Shenyang Kesi High-Technology Co, Ltd.

发明人： Jinsong Zhang ,  Mingtian Li ,  Zhiyu Liu ,  Lei Xu

IPC分类号： C08B37/00 ,  C08H8/00

CPC分类号： C08B37/0003 ,  C08B37/006 ,  C08H8/00

摘要： This invention relates to a field of pharmaceutical chemistry, relates to a process of extracting high water soluble polysaccharides from higher plants or fungi. The present invention discloses a process of extracting higher plants and fungi polysaccharides based on a microwave chemistry method, comprising: putting the residue or pulverized higher plants and fungi after being degreased by an organic solvent into a microwave reaction chamber to react with an acid solution; and then distilling to remove excess acid or washing with organic solvent to remove the acid; adding water solution for extraction, subjecting the extracting solution after concentration to alcohol precipitation, separating precipitates aka polysaccharides therefrom.The present invention has significant advantages like fast processing rate, high polysaccharides yield, low organic acid consumption and efficient and easy to recycle, low water consumption, low power consumption, etc., and obtained polysaccharides have high yield and purity, good water solubility, and good biological activity.

摘要翻译： 本发明具有加工速度快，多糖收率高，有机酸消耗低，易回收，耗水少，功耗低等特点，得到的多糖具有产率高，纯度高，水溶性好， 和良好的生物活性。

公开(公告)号：US09447199B2

公开(公告)日：2016-09-20

申请号：US14355535

申请日：2012-11-01

申请人： Shenyang Kesi High-Technology Co, Ltd.

发明人： Jinsong Zhang ,  Mingtian Li ,  Zhiyu Liu ,  Lei Xu

IPC分类号： C08B37/00 ,  C08L5/04

CPC分类号： C08B37/0084 ,  C08B37/0003 ,  C08L5/04

摘要： This invention relates to an extraction process of brown algae polysaccharides in a field of pharmaceutical chemistry. This invention particularly discloses a process of extracting brown algae polysaccharides based on a microwave chemistry method and brown algae polysaccharides obtained by said process. The process of the invention comprises: 1) putting pulverized brown algae powder into a microwave reaction chamber, adding acid solution to conduct reaction; optionally concentrating the mixer, and then washing with organic solvent to remove excess acid; conducting grading alcohol precipitation after water extract to obtain mannuronic acid rich fragment (M rich) algin, fucoidan and/or laminaran respectively; and adding an alkali solution to the brown algae residue to conduct alkaline digestion, filtering the residue off, adjusting pH of the filtrate to neutral, conducting alcohol precipitation to obtain guluronic acid rich fragment (G rich) algin precipitates. The present invention has significant advantages like fast processing rate, high yield of polysaccharides, strong controllable polysaccharide degradation, using less organic acid and efficient recovery, small water consumption, low power consumption, etc., the active polysaccharides has high yield and content, better water-soluble, and good biological activities.

摘要翻译： 本发明涉及药物化学领域中褐藻多糖的提取方法。 本发明特别公开了一种基于微波化学方法提取褐藻多糖的方法和通过所述方法获得的褐藻多糖。 本发明的方法包括：1）将粉碎的褐藻粉放入微波反应室中，加酸溶液进行反应; 任选地浓缩混合器，然后用有机溶剂洗涤以除去过量的酸; 在水提取物后进行分级酒精沉淀，分别得到富含甘露糖醛酸的片段（富M），藻酸盐和/或层流蛋白; 并向棕色藻类残渣中加入碱溶液进行碱性消化，过滤残余物，调节滤液pH至中性，进行酒精沉淀，得到富含富罗勒浓的片段（富G）藻酸盐沉淀物。 本发明具有加工速度快，多糖收率高，多糖降解可靠，有机酸少，有效回收，耗水量少，功耗低等优点，活性多糖具有较高的产量和含量，较好的 水溶性好，生物活性好。

公开(公告)号：US20140309414A1

公开(公告)日：2014-10-16

申请号：US14355531

申请日：2012-11-01

申请人： Shenyang Kesi High-Technology Co., Ltd.

发明人： Jinsong Zhang ,  Mingtian Li ,  Zhiyu Liu ,  Lei Xu

IPC分类号： C08B37/00

CPC分类号： C08B37/0003 ,  C08B37/006 ,  C08H8/00

摘要： This invention relates to a field of pharmaceutical chemistry, relates to a process of extracting high water soluble polysaccharides from higher plants or fungi. The present invention discloses a process of extracting higher plants and fungi polysaccharides based on a microwave chemistry method, comprising: putting the residue or pulverized higher plants and fungi after being degreased by an organic solvent into a microwave reaction chamber to react with an acid solution; and then distilling to remove excess acid or washing with organic solvent to remove the acid; adding water solution for extraction, subjecting the extracting solution after concentration to alcohol precipitation, separating precipitates aka polysaccharides therefrom.The present invention has significant advantages like fast processing rate, high polysaccharides yield, low organic acid consumption and efficient and easy to recycle, low water consumption, low power consumption, etc., and obtained polysaccharides have high yield and purity, good water solubility, and good biological activity.

摘要翻译： 本发明涉及药物化学领域，涉及从高等植物或真菌中提取高水溶性多糖的方法。 本发明公开了一种基于微波化学方法提取高等植物和真菌多糖的方法，包括：将有机溶剂脱脂后的残余物或粉碎的高等植物和真菌放入微波反应室中与酸溶液反应; 然后蒸馏除去过量的酸或用有机溶剂洗涤以除去酸; 加入水溶液进行萃取，浓缩后将萃取液进行酒精沉淀，分离析出的沉淀物，称为多糖。 本发明具有加工速度快，多糖收率高，有机酸消耗低，易回收，耗水少，功耗低等特点，得到的多糖具有产率高，纯度高，水溶性好， 和良好的生物活性。