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1.发明申请公开(公告)号：US20050059719A1
公开(公告)日：2005-03-17
申请号：US10924043
申请日：2004-08-23
申请人： Sherif Badawy , Munir Hussain , Duxin Sun
发明人： Sherif Badawy , Munir Hussain , Duxin Sun
CPC分类号： A61K9/2054 , A61K31/42
摘要： An oral solid dosage formulation is provided which contains a Factor Xa inhibitor for which oral bioavailability is not reduced by co-administration of antacids, H2 antagonists and proton pump inhibitors. Such solid dosage formulation includes the Factor Xa inhibitor of the structure, a pharmaceutically acceptable carrier, and an acid component, such as tartaric acid, whereby upon ingestion of the oral solid dosage formulation, the acid component increases solubility of the Factor Xa inhibitor in the local environment of the dissolving solid dosage formulation resulting in an otherwise lower degree of supersaturation of the Factor Xa inhibitor in such environment, than if the acid were not present. The result is that precipitation of the Factor Xa inhibitor in the form of its insoluble free base is minimized during dissolution of the Factor Xa inhibitor thereby increasing its oral bioavailability. A method for enhancing bioavailability of the Factor Xa inhibitor is also provided wherein an acid such as tartaric acid is incorporated with the solid dosage pharmaceutical carrier for the Factor Xa inhibitor.
摘要翻译： 提供口服固体剂量制剂，其含有通过共同给予抗酸剂，H 2拮抗剂和质子泵抑制剂而不降低口服生物利用度的因子Xa抑制剂。 这种固体剂量制剂包括结构的因子Xa抑制剂，药学上可接受的载体和酸组分，例如酒石酸，由此，在摄取口服固体剂量制剂后，酸组分增加因子Xa抑制剂在 溶解固体剂量制剂的局部环境导致因素Xa抑制剂在这种环境中的过饱和程度低于不存在酸的情况。 结果是在因子Xa抑制剂的溶解过程中，其不溶性游离碱形式的因子Xa抑制剂的沉淀被最小化，从而增加其口服生物利用度。 还提供了用于提高因子Xa抑制剂的生物利用度的方法，其中将诸如酒石酸的酸与用于因子Xa抑制剂的固体剂量药物载体结合。
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公开(公告)号：US10765599B2
公开(公告)日：2020-09-08
申请号：US15875814
申请日：2018-01-19
申请人： Sherif Badawy
发明人： Sherif Badawy
摘要： A decorative medication holder may reduce or eliminate medication non-adherence and work with standard and/or non-standard medication containers. The medication holder may include a body portion having an opening to a medication retaining cavity adapted for receiving a medication, such as a bottle of pills. The body portion also may be decorated with a kid-friendly aesthetic design, such as a character, animal, or the like to engage a child's interest. In some embodiments, the body portion may include a substantially flat outer surface. Alternatively, the body portion also may include three-dimensional limbs or the like which may be rigid or posable. In some embodiments, a cover may be provided to close the opening and/or secure the medication in the cavity. Alternatively, or additionally, the cavity may include textured lining or the like to grip the medication in the cavity. Other embodiments also are described.
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公开(公告)号：USD920126S1
公开(公告)日：2021-05-25
申请号：US29634280
申请日：2018-01-19
申请人： Sherif Badawy
设计人： Sherif Badawy
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公开(公告)号：US20190224072A1
公开(公告)日：2019-07-25
申请号：US15875814
申请日：2018-01-19
申请人： Sherif Badawy
发明人： Sherif Badawy
摘要： A decorative medication holder may reduce or eliminate medication non-adherence and work with standard and/or non-standard medication containers. The medication holder may include a body portion having an opening to a medication retaining cavity adapted for receiving a medication, such as a bottle of pills. The body portion also may be decorated with a kid-friendly aesthetic design, such as a character, animal, or the like to engage a child's interest. In some embodiments, the body portion may include a substantially flat outer surface. Alternatively, the body portion also may include three-dimensional limbs or the like which may be rigid or posable. In some embodiments, a cover may be provided to close the opening and/or secure the medication in the cavity. Alternatively, or additionally, the cavity may include textured lining or the like to grip the medication in the cavity. Other embodiments also are described.
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