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公开(公告)号:US5948784A
公开(公告)日:1999-09-07
申请号:US89255
申请日:1998-06-03
申请人: Shigeki Fujiwara , Yuko Okamura , Haruki Takai , Hiromi Nonaka , Takahiro Moriyama , Kozo Yao , Akira Karasawa
发明人: Shigeki Fujiwara , Yuko Okamura , Haruki Takai , Hiromi Nonaka , Takahiro Moriyama , Kozo Yao , Akira Karasawa
IPC分类号: A61K31/505 , A61P9/00 , A61P9/10 , A61P43/00 , C07D401/14
CPC分类号: C07D401/14
摘要: Disclosed are quinazoline derivatives represented by formula (I): wherein R.sup.1 represents hydrogen, lower alkyl, alkenyl, or aralkyl; R.sup.2, R.sup.3, R.sup.4, and R.sup.5 represent hydrogen, lower alkyl, lower alkoxy, lower alkanoyl, or the like; R.sup.6, R.sup.7, R.sup.8, and R.sup.9 represent hydrogen, lower alkyl, lower alkoxy, aralkyloxy, or the like, or any adjoining two of them are combined to form methylenedioxy or the like; R.sup.10 represents hydrogen, lower alkyl, or the like; R.sup.11 and R.sup.12 represent hydrogen, lower alkyl, cycloalkyl, phenyl, or aralkyl, or R.sup.11 and R.sup.12 are combined together with N to form a heterocyclic group; and n represents 0, 1 or 2, and pharmaceutically acceptable salts thereof. These compounds have adenosine uptake inhibitory activity and are useful for the protection of myocardium and for the prevention or treatment of renal diseases such as nephritis and diabetic nephropathy.
摘要翻译: 公开了由式(I)表示的喹唑啉衍生物:其中R1表示氢,低级烷基,烯基或芳烷基; R2,R3,R4和R5代表氢,低级烷基,低级烷氧基,低级烷酰基等; R 6,R 7,R 8和R 9表示氢,低级烷基,低级烷氧基,芳烷氧基等,或者其中任意相邻的两个相结合形成亚甲二氧基等; R 10表示氢,低级烷基等; R 11和R 12表示氢,低级烷基,环烷基,苯基或芳烷基,或R 11和R 12与N一起形成杂环基; 和n表示0,1或2,及其药学上可接受的盐。 这些化合物具有腺苷摄取抑制活性,可用于保护心肌和预防或治疗肾脏疾病如肾炎和糖尿病肾病。
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公开(公告)号:US5866574A
公开(公告)日:1999-02-02
申请号:US56710
申请日:1998-04-08
申请人: Yuko Okamura , Junichi Shimada , Toru Noji , Chikako Katagiri , Akira Karasawa
发明人: Yuko Okamura , Junichi Shimada , Toru Noji , Chikako Katagiri , Akira Karasawa
IPC分类号: A61K31/517 , A61K31/53 , A61K31/495 , A61K31/505
CPC分类号: A61K31/517
摘要: The present invention relates to a prophylactic agent or a therapeutic agent of pancreatitis, containing an adenosine uptake inhibitor or a pharmaceutically acceptable salt thereof.
摘要翻译: 本发明涉及含有腺苷摄取抑制剂或其药学上可接受的盐的胰腺炎的预防剂或治疗剂。
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公开(公告)号:US5503686A
公开(公告)日:1996-04-02
申请号:US402893
申请日:1995-03-13
申请人: Yuko Okamura , Keiji Ohkubo , Osamu Saito , Toyoji Ataka
发明人: Yuko Okamura , Keiji Ohkubo , Osamu Saito , Toyoji Ataka
CPC分类号: G11B5/3967 , C21D1/04 , C22F1/10 , G11B5/3163 , G11B5/3113
摘要: A magnetic recording head that includes a combined IN element and an MR element is heat treated under two types of magnetic fields. A rotating magnetic field, having a first magnetic field intensity, is applied for a time while the magnetic recording head is at an elevated temperature. Then, part-way during cooling of the magnetic head, the rotating magnetic field is replaced by a direct (non-rotating) magnetic field having a second magnetic field intensity. The second magnetic field intensity is lower than the first magnetic field intensity, whereby the properties of both the IN element and the MR element are maintained at high values.
摘要翻译: 包括组合的IN元件和MR元件的磁记录头在两种类型的磁场下进行热处理。 具有第一磁场强度的旋转磁场在磁记录头处于升高的温度下被施加一段时间。 然后,在磁头的冷却过程中,单向旋转磁场由具有第二磁场强度的直接(非旋转)磁场代替。 第二磁场强度低于第一磁场强度,由此将IN元件和MR元件的性质保持在高值。
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