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公开(公告)号：US08034763B2
公开(公告)日：2011-10-11
申请号：US12065701
申请日：2006-11-02
申请人： Shigeto Yoshida , Toshiki Sudo
发明人： Shigeto Yoshida , Toshiki Sudo
CPC分类号： C07K14/43563 , A61K38/17 , G01N33/5088
摘要： The invention provides a pharmaceutical composition comprising at least one polypeptide of the following (a) to (d): (a) a polypeptide comprising the amino acid sequence of SEQ ID NO:1; (b) a polypeptide comprising an amino acid sequence comprising one or more amino acid deletions, insertions, substitutions or additions in the amino acid sequence of the above (a) and having a platelet aggregation inhibitory activity and/or a platelet adhesion inhibitory activity; (c) a polypeptide comprising the amino acid sequence of SEQ ID NO:3; and (d) a polypeptide comprising an amino acid sequence comprising one or more amino acid deletions, insertions, substitutions or additions in the amino acid sequence of the above (c) and having a platelet aggregation inhibitory activity and/or a platelet adhesion inhibitory activity, as an active component.
摘要翻译： 本发明提供了包含以下（a）至（d）的至少一种多肽的药物组合物：（a）包含SEQ ID NO：1的氨基酸序列的多肽; （b）包含在上述（a）的氨基酸序列中包含一个或多个氨基酸缺失，插入，取代或添加并具有血小板聚集抑制活性和/或血小板粘附抑制活性的氨基酸序列的多肽; （c）包含SEQ ID NO：3的氨基酸序列的多肽; 和（d）包含在上述（c）的氨基酸序列中包含一个或多个氨基酸缺失，插入，取代或添加并具有血小板聚集抑制活性和/或血小板粘附抑制活性的氨基酸序列的多肽 ，作为活性成分。
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公开(公告)号：US08309512B2
公开(公告)日：2012-11-13
申请号：US13215004
申请日：2011-08-22
申请人： Shigeto Yoshida , Toshiki Sudo
发明人： Shigeto Yoshida , Toshiki Sudo
CPC分类号： C07K14/43563 , A61K38/17 , G01N33/5088
摘要： The invention provides a pharmaceutical composition comprising at least one polypeptide of the following (a) to (d):(a) a polypeptide comprising the amino acid sequence of SEQ ID NO:1;(b) a polypeptide comprising an amino acid sequence comprising one or more amino acid deletions, insertions, substitutions or additions in the amino acid sequence of the above (a) and having a platelet aggregation inhibitory activity and/or a platelet adhesion inhibitory activity; (c) a polypeptide comprising the amino acid sequence of SEQ ID NO:3; and (d) a polypeptide comprising an amino acid sequence comprising one or more amino acid deletions, insertions, substitutions or additions in the amino acid sequence of the above (c) and having a platelet aggregation inhibitory activity and/or a platelet adhesion inhibitory activity, as an active component.
摘要翻译： 本发明提供了包含以下（a）至（d）的至少一种多肽的药物组合物：（a）包含SEQ ID NO：1的氨基酸序列的多肽; （b）包含在上述（a）的氨基酸序列中包含一个或多个氨基酸缺失，插入，取代或添加并具有血小板聚集抑制活性和/或血小板粘附抑制活性的氨基酸序列的多肽; （c）包含SEQ ID NO：3的氨基酸序列的多肽; 和（d）包含在上述（c）的氨基酸序列中包含一个或多个氨基酸缺失，插入，取代或添加并具有血小板聚集抑制活性和/或血小板粘附抑制活性的氨基酸序列的多肽 ，作为活性成分。
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公开(公告)号：US20100004164A1
公开(公告)日：2010-01-07
申请号：US12065701
申请日：2006-11-02
申请人： Shigeto Yoshida , Toshiki Sudo
发明人： Shigeto Yoshida , Toshiki Sudo
IPC分类号： A61K38/17 , C07K14/435 , C12Q1/02 , C07H21/04
CPC分类号： C07K14/43563 , A61K38/17 , G01N33/5088
摘要： The invention provides a pharmaceutical composition comprising at least one polypeptide of the following (a) to (d): (a) a polypeptide comprising the amino acid sequence of SEQ ID NO:1; (b) a polypeptide comprising an amino acid sequence comprising one or more amino acid deletions, insertions, substitutions or additions in the amino acid sequence of the above (a) and having a platelet aggregation inhibitory activity and/or a platelet adhesion inhibitory activity; (c) a polypeptide comprising the amino acid sequence of SEQ ID NO:3; and (d) a polypeptide comprising an amino acid sequence comprising one or more amino acid deletions, insertions, substitutions or additions in the amino acid sequence of the above (c) and having a platelet aggregation inhibitory activity and/or a platelet adhesion inhibitory activity, as an active component.
摘要翻译： 本发明提供了包含以下（a）至（d）的至少一种多肽的药物组合物：（a）包含SEQ ID NO：1的氨基酸序列的多肽; （b）包含在上述（a）的氨基酸序列中包含一个或多个氨基酸缺失，插入，取代或添加并具有血小板聚集抑制活性和/或血小板粘附抑制活性的氨基酸序列的多肽; （c）包含SEQ ID NO：3的氨基酸序列的多肽; 和（d）包含在上述（c）的氨基酸序列中包含一个或多个氨基酸缺失，插入，取代或添加并具有血小板聚集抑制活性和/或血小板粘附抑制活性的氨基酸序列的多肽 ，作为活性成分。
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