公开(公告)号：US07887837B2

公开(公告)日：2011-02-15

申请号：US12087424

申请日：2007-01-05

申请人： Shinji Takeoka ,  Yousuke Okamura ,  Ippei Maekawa ,  Makoto Handa ,  Yasuo Ikeda

发明人： Shinji Takeoka ,  Yousuke Okamura ,  Ippei Maekawa ,  Makoto Handa ,  Yasuo Ikeda

IPC分类号： A61K9/127

CPC分类号： A61K31/7076 ,  A61K47/542 ,  A61K47/543 ,  A61K47/60 ,  A61K47/6911

摘要： The present invention provides a drug delivery material, which is a conjugate of 1) a drug-carrying molecular assembly, 2) a linker and 3) a substance that recognizes activated platelet, injury site of blood vessel and/or inflammatory tissue, and capable of efficiently delivering a drug to a desired site, during which the drug under delivery does not affect sites other than a desired site (hence, low possibility of causing side effects), which releases the drug only at the desired site without requiring an external means and allows the drug to exhibit an effect.

摘要翻译： 本发明提供药物递送材料，其是1）药物携带分子组合物的缀合物，2）接头和3）识别活化血小板，血管和/或炎性组织的损伤部位的物质，并且能够 有效地将药物递送到期望的部位，在此期间，药物在输送期间不会影响除期望部位以外的部位（因此，引起副作用的可能性很小），其仅在所需部位释放药物，而不需要外部手段 并允许药物表现出效果。

公开(公告)号：US20090220422A1

公开(公告)日：2009-09-03

申请号：US12087424

申请日：2007-01-05

申请人： Shinji Takeoka ,  Yousuke Okamura ,  Ippei Maekawa ,  Makoto Handa ,  Yasuo Ikeda

发明人： Shinji Takeoka ,  Yousuke Okamura ,  Ippei Maekawa ,  Makoto Handa ,  Yasuo Ikeda

IPC分类号： A61K49/00 ,  A61K9/127 ,  A61K31/70 ,  A61K38/39 ,  A61K31/60

CPC分类号： A61K31/7076 ,  A61K47/542 ,  A61K47/543 ,  A61K47/60 ,  A61K47/6911

摘要： The present invention provides a drug delivery material, which is a conjugate of 1) a drug-carrying molecular assembly, 2) a linker and 3) a substance that recognizes activated platelet, injury site of blood vessel and/or inflammatory tissue, and capable of efficiently delivering a drug to a desired site, during which the drug under delivery does not affect sites other than a desired site (hence, low possibility of causing side effects), which releases the drug only at the desired site without requiring an external means and allows the drug to exhibit an effect.

摘要翻译： 本发明提供药物递送材料，其是1）药物携带分子组合物的缀合物，2）接头和3）识别活化血小板，血管和/或炎性组织的损伤部位的物质，并且能够 有效地将药物递送到期望的部位，在此期间，药物在输送期间不会影响除期望部位以外的部位（因此，引起副作用的可能性很小），其仅在所需部位释放药物，而不需要外部手段 并允许药物表现出效果。

公开(公告)号：US08192819B2

公开(公告)日：2012-06-05

申请号：US12327749

申请日：2008-12-03

申请人： Ippei Maekawa ,  Tomonori Endo ,  Mamoru Uchida ,  Yuki Takei ,  Yuaki Shin

发明人： Ippei Maekawa ,  Tomonori Endo ,  Mamoru Uchida ,  Yuki Takei ,  Yuaki Shin

IPC分类号： B32B3/02

CPC分类号： B41M5/52 ,  B41M5/506 ,  B41M5/5218 ,  B41M5/5227 ,  B41M5/5254 ,  B41M2205/38 ,  G11B7/24 ,  Y10T428/21

摘要： Disc-shaped information recording medium comprising optical penetrating substrate having colored underlayer and ink receipt layer in this order on the principal surface of one side of the substrate, wherein the ink receipt layer contains inorganic fine particles, a binder, and a crosslinking agent, and wherein a pore diameter distribution of a gap of the ink receipt layer has a maximum peak in the range of 30 nm or more when the ink receipt layer is measured with a mercury porosimetry method. Since the shrinkage force functioning in the pores of the gaps of the ink receipt layer weakens, a disc-shaped information recording medium having a reduced occurrence of warp is provided.

摘要翻译： 盘形信息记录介质，其包括具有彩色底层的光学穿透基板和在该基板的一侧的主表面上的油墨接收层，其中，墨水容纳层包含无机细颗粒，粘合剂和交联剂，以及 其中当使用水银孔隙法测量墨水接收层时，墨水接收层的间隙的孔径分布具有在30nm以上范围内的最大峰值。 由于在墨水接收层的间隙的孔隙中发挥的收缩力变弱，因此提供了具有减少的翘曲发生的盘状信息记录介质。

公开(公告)号：US20090169798A1

公开(公告)日：2009-07-02

申请号：US12327749

申请日：2008-12-03

申请人： Ippei Maekawa ,  Tomonori Endo ,  Mamonu Uchida ,  Yuki Takei ,  Yuaki Shin

发明人： Ippei Maekawa ,  Tomonori Endo ,  Mamonu Uchida ,  Yuki Takei ,  Yuaki Shin

IPC分类号： G11B7/246

CPC分类号： B41M5/52 ,  B41M5/506 ,  B41M5/5218 ,  B41M5/5227 ,  B41M5/5254 ,  B41M2205/38 ,  G11B7/24 ,  Y10T428/21

摘要： Disc-shaped information recording medium comprising optical penetrating substrate having colored underlayer and ink receipt layer in this order on the principal surface of one side of the substrate, wherein the ink receipt layer contains inorganic fine particles, a binder, and a crosslinking agent, and wherein a pore diameter distribution of a gap of the ink receipt layer has a maximum peak in the range of 30 nm or more when the ink receipt layer is measured with a mercury porosimetry method. Since the shrinkage force functioning in the pores of the gaps of the ink receipt layer weakens, a disc-shaped information recording medium having a reduced occurrence of warp is provided.

摘要翻译： 盘形信息记录介质，其包括具有彩色底层的光学穿透基板和在该基板的一侧的主表面上的油墨接收层，其中，墨水容纳层包含无机细颗粒，粘合剂和交联剂，以及 其中当使用水银孔隙法测量墨水接收层时，墨水接收层的间隙的孔径分布具有在30nm以上范围内的最大峰值。 由于在墨水接收层的间隙的孔隙中发挥的收缩力变弱，因此提供了具有减少的翘曲发生的盘状信息记录介质。

公开(公告)号：US20090034390A1

公开(公告)日：2009-02-05

申请号：US12035364

申请日：2008-02-21

申请人： Hidenori Somei ,  Satoshi Kobayashi ,  Ippei Maekawa

发明人： Hidenori Somei ,  Satoshi Kobayashi ,  Ippei Maekawa

IPC分类号： G11B7/00 ,  B32B3/02

CPC分类号： G11B23/40 ,  G11B7/2403 ,  G11B7/24094

摘要： An optical information recording medium capable of being drawn without being overturned by an optical information recording apparatus and cable of being drawn not depending on the wavelength of a laser light to be irradiated, the optical information recording medium having an information recording portion in which a recording layer and a first reflection layer are formed successively on a first substrate, and having a drawing portion in which a second reflection layer, a color-change layer, a color-change assistance layer, and a protection layer are formed successively on a second substrate, in which the second reflection layer is heated by irradiation of a laser light and the material in the color-change layer and the material in the color-change assistance layer are melted by the heat and mixed to cause a color change thereby forming images.

摘要翻译： 一种光学信息记录介质，其能够被光学信息记录装置和不被照射的激光的波长绘制而不被光学信息记录装置和电缆翻转而被绘制，所述光学信息记录介质具有信息记录部分，其中记录 层和第一反射层依次形成在第一基板上，并且具有在第二基板上依次形成第二反射层，变色层，变色辅助层和保护层的绘图部分 其中通过照射激光来加热第二反射层，并且颜色变化层中的材料和变色辅助层中的材料通过热熔化并混合从而引起颜色变化从而形成图像。