公开(公告)号：US07714077B2

公开(公告)日：2010-05-11

申请号：US10563560

申请日：2004-07-07

申请人： Shinji Tanaka ,  Kenji Kato ,  Yuichi Ohya ,  Tatsuo Ouchi

发明人： Shinji Tanaka ,  Kenji Kato ,  Yuichi Ohya ,  Tatsuo Ouchi

IPC分类号： C08F283/06 ,  C08G69/10 ,  C08G69/48 ,  C08G63/08 ,  C08G63/664 ,  C08G81/00

CPC分类号： C08G63/664 ,  C08G63/6852 ,  C08G2261/126

摘要： The present invention relates to a triblock copolymer, that is multipurpose yet has sufficient properties particularly for medical applications, and is useful as a material having excellent flexibility and water absorbability, as well as to a method for producing the same, and a biocompatible material. The copolymer of the present invention is composed of segments A1 and A2 each composed of a polymer having a depsipeptide unit, such as a segment selected from a homopolymer of depsipeptide or a copolymer of lactide and depsipeptide, and segment B composed of polyalkylene glycol, such as PEG, and is a A1-B-A2 triblock copolymer having a number average molecular weight of 8000 to 500000. The biocompatible material of the present invention contains the triblock copolymer as a main component, and may be used as a tissue anti-adhesion barrier.

摘要翻译： 本发明涉及三嵌段共聚物，其多功能性具有特别适用于医疗应用的足够特性，并且可用作具有优异的柔软性和吸水性的材料，以及其制备方法和生物相容性材料。 本发明的共聚物由分段A1和A2组成，分段A1和A2各自由具有缩肽单元的聚合物组成，所述聚合物具有选自前肽的均聚物，丙交酯和缩酚酸酯的共聚物的片段，以及由聚亚烷基二醇组成的链段B， 作为PEG，并且是数均分子量为8000〜500000的A1-B-A2三嵌段共聚物。本发明的生物相容性材料含有三嵌段共聚物作为主要成分，可用作组织抗粘连 屏障。

公开(公告)号：US20060223975A1

公开(公告)日：2006-10-05

申请号：US10563560

申请日：2004-07-07

申请人： Shinji Tanaka ,  Kenji Kato ,  Yuichi Ohya ,  Tatsuo Ouchi

发明人： Shinji Tanaka ,  Kenji Kato ,  Yuichi Ohya ,  Tatsuo Ouchi

IPC分类号： C08G69/10

CPC分类号： C08G63/664 ,  C08G63/6852 ,  C08G2261/126

摘要： The present invention relates to a triblock copolymer, that is multipurpose yet has sufficient properties particularly for medical applications, and is useful as a material having excellent flexibility and water absorbability, as well as to a method for producing the same, and a biocompatible material. The copolymer of the present invention is composed of segments A1 and A2 each composed of a polymer having a depsipeptide unit, such as a segment selected from a homopolymer of depsipeptide or a copolymer of lactide and depsipeptide, and segment B composed of polyalkylene glycol, such as PEG, and is a A1-B-A2 triblock copolymer having a number average molecular weight of 8000 to 500000. The biocompatible material of the present invention contains the triblock copolymer as a main component, and may be used as a tissue anti-adhesion barrier.

摘要翻译： 本发明涉及三嵌段共聚物，其多功能性具有特别适用于医疗应用的足够特性，并且可用作具有优异的柔软性和吸水性的材料，以及其制备方法和生物相容性材料。 本发明的共聚物由具有脱肽肽单元的聚合物组成的段A 1和A 2组成，例如选自前肽的均聚物或 丙交酯和缩酚酸酯的共聚物，以及由聚亚烷基二醇（如PEG）组成的片段B，并且是数均分子量为1的2-S-2 8000〜500000。本发明的生物相容性材料含有三嵌段共聚物作为主要成分，可用作组织抗粘连屏障。