专利检索 ap:("Shire Human Genetic Therapies, Inc." OR "University of Pittsburgh-Of The Commonwealth System of Higher Education") AND inv:"Daniel Minard Lajole" 第 1 页

1.

发明申请
Recombinant Heme Oxygenase-1 (HO-1) for the Treatment of Sickle Cell Disease 有权

公开(公告)号：US20230018417A1

公开(公告)日：2023-01-19

申请号：US17623503

申请日：2020-07-24

申请人： Shire Human Genetic Therapies, Inc. , University of Pittsburgh-Of The Commonwealth System of Higher Education

发明人： Solomon Fiifi Ofori-Acquah , Samit Ghosh , Joseph Sypek , Bohong Zhang , Xiuxia Sun , Clark Q. Pan , Daniel Minard Lajole , Chuan Shen

IPC分类号： A61K38/44 , A61P7/06 , C12N15/62 , C12N9/02

摘要： The present invention provides, among other things, methods and compositions for making and using recombinant heme oxygenase for treating sickle cell disease. In some embodiments, recombinant heme oxygenase proteins are truncation variants, or Fc fusion proteins with increased half-life and/or reduced aggregation.