公开(公告)号：US20020102306A1

公开(公告)日：2002-08-01

申请号：US10035077

申请日：2001-12-28

申请人： Shire Laboratories, Inc.

发明人： Edward M. Rudnic ,  Beth A. Burnside ,  Henry H. Flanner ,  Sandra E. Wassink ,  Richard A. Couch

IPC分类号： A61K009/24 ,  A61K031/426

CPC分类号： A61K9/0004 ,  Y10S514/96

摘要： Disclosed is an osmotic pharmaceutical delivery system comprising (a) a semi-permeable wall that maintains its integrity during pharmaceutical delivery and which has at least one passage therethrough; b) a single, homogeneous composition within said wall, which composition consists essentially of (i) a pharmaceutically active agent, (ii) at least one non-swelling solubilizing agent which enhances the solubility of the pharmaceutically active agent; (iii) at least one non-swelling osmotic agent and (iv) a non-swelling wicking agent dispersed throughout the composition which enhances the surface area contact of the pharmaceutical agent with the incoming aqueous fluid.

摘要翻译： 公开了一种渗透性药物递送系统，其包括（a）半透壁，其在药物递送期间保持其完整性，并且具有至少一个通过其的通道; b）所述壁内的单一均匀组合物，该组合物基本上由（i）药物活性剂，（ii）至少一种增强药物活性剂的溶解度的非溶胀增溶剂组成; （iii）至少一种非溶胀渗透剂和（iv）分散在整个组合物中的不溶胀芯吸剂，其增强药剂与进入的含水流体的表面积接触。