公开(公告)号：US20070178088A1

公开(公告)日：2007-08-02

申请号：US11726220

申请日：2007-03-21

申请人： Shujian Wu ,  Stanley Krystek ,  Liana Lee ,  John Feder ,  Janet Cheng

发明人： Shujian Wu ,  Stanley Krystek ,  Liana Lee ,  John Feder ,  Janet Cheng

IPC分类号： A61K39/395 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28 ,  A61K38/17

CPC分类号： C07K14/705 ,  A61K38/00

摘要： The present invention provides novel polynucleotides encoding BGS-2, 3, and 4 polypeptides, fragments and homologues thereof Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-2, 3, and 4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码BGS-2,3和4多肽，其片段和同系物的新型多核苷酸。还提供了用于产生所述多肽的载体，宿主细胞，抗体以及重组和合成方法。 本发明还涉及将这些新型BGS-2,3和4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。