公开(公告)号：US11008322B1

公开(公告)日：2021-05-18

申请号：US16842744

申请日：2020-04-07

Applicant: Sichuan University

Inventor： Fener Chen ,  Pei Tang ,  Wen Zhang ,  Lin Dong ,  Youcai Xiao

IPC: C07D471/14

Abstract: Disclosed herein is a method of synthesizing a (1S,12bS) lactam ester compound, including: subjecting a dihydrocarboline diester compound of formula (II) to asymmetric hydrogenation and lactamization in an organic solvent in the presence of an iridium catalyst precursor, a chiral diphosphine ligand and a halogen-containing reagent under hydrogen atmosphere to produce the (1S,12bS) lactam ester compound of formula (I), as shown in the following reaction scheme, where R1, R2 and R3 are defined in the same manner with the specification.