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    Method and device for examining the attachment or detachment of living or dead cells or cell-like particles or other surface accumulations on surfaces by means of plasmon resonance and use of said method and said device
    1.
    发明授权
    Method and device for examining the attachment or detachment of living or dead cells or cell-like particles or other surface accumulations on surfaces by means of plasmon resonance and use of said method and said device 失效
    用于通过等离子体共振和使用所述方法和所述装置检查生物或死细胞或细胞样颗粒或表面上的其它表面积聚物附着或分离的方法和装置

    公开(公告)号：US08232061B2

    公开(公告)日：2012-07-31

    申请号：US12525418

    申请日：2008-02-01

    申请人： Andreas Hofmann ,  Norbert Danz ,  Silke Hofmann ,  Michael Keusgen ,  Ulla Magdolen

    发明人： Andreas Hofmann ,  Norbert Danz ,  Silke Hofmann ,  Michael Keusgen ,  Ulla Magdolen

    IPC分类号： G01N33/53

    CPC分类号： G01N21/553

    摘要： A method for examining an attachment or detachment of living cells, dead cells or cell-like particles on a surface using plasmon resonance includes irradiating a measurement region with beams over the entire angle of incidence spectrum and capturing, combining and evaluating beams with identical angles of incidence reflected from different points of the measurement region with a determination of the angle of light incidence with a lowest reflected light intensity and measuring an angle of incidence shift of an intensity minimum that occurs. The evaluating includes registering different angles of incidence of two or more intensity minima occurring simultaneously to reflect a respective level of the surface accumulations.

    摘要翻译： 使用等离子体共振检查表面上的活细胞，死细胞或细胞样颗粒的附着或分离的方法包括：在整个入射光谱上照射具有光束的测量区域，并且捕获，组合和评估具有相同角度 通过确定具有最低反射光强度的光入射角度并测量出现的强度最小值的入射偏移角，测量区域的不同点反射的入射。 评估包括记录同时发生的两个或更多个强度最小值的不同入射角，以反映表面积累的相应水平。

    METHOD AND DEVICE FOR EXAMINING THE ATTACHMENT OR DETACHMENT OF LIVING OR DEAD CELLS OR CELL-LIKE PARTICLES OR OTHER SURFACE ACCUMULATIONS ON SURFACES BY MEANS OF PLASMON RESONANCE AND USE OF SAID METHOD AND SAID DEVICE
    2.
    发明申请
    METHOD AND DEVICE FOR EXAMINING THE ATTACHMENT OR DETACHMENT OF LIVING OR DEAD CELLS OR CELL-LIKE PARTICLES OR OTHER SURFACE ACCUMULATIONS ON SURFACES BY MEANS OF PLASMON RESONANCE AND USE OF SAID METHOD AND SAID DEVICE 失效
    方法和装置，用于通过平均共振方法检测生活或死亡细胞或细胞样颗粒或其他表面积累表面积的附着或分离，以及使用方法和设备的使用

    公开(公告)号：US20100028903A1

    公开(公告)日：2010-02-04

    申请号：US12525418

    申请日：2008-02-01

    申请人： Silke Hofmann ,  Andreas Hofmann ,  Norbert Danz ,  Michael Keusgen ,  Ulla Magdolen

    发明人： Silke Hofmann ,  Andreas Hofmann ,  Norbert Danz ,  Michael Keusgen ,  Ulla Magdolen

    IPC分类号： G01N33/53 ,  G01N21/55 ,  C12Q1/02

    CPC分类号： G01N21/553

    摘要： The invention relates to the examination of the attachment or detachment of living or dead cells, or cell-like particles, or other surface accumulations on surfaces, by means of plasmon resonance. The reflected light is evaluated such that two or more intensity minima of the reflected light occurring within a time frame are registered in a time dependant manner for different incident angles. The registered measurement signals reflect the respective amount of the surface accumulation. In case two intensity minima have occurred at the same time, valuable information about particular processes regarding the surface accumulation, for example regarding the adhesion of cells, can be obtained. Said information is of particular importance in the field of medicine/biology.

    摘要翻译： 本发明涉及通过等离子共振来检查活体或死细胞，细胞样颗粒或表面上的其它表面积聚物的附着或分离。 评估反射光，使得在时间范围内发生的反射光的两个或更多个强度最小值以时间依赖的方式登记到不同的入射角。 注册的测量信号反映表面积累的相应量。 在同时发生两个强度最小值的情况下，可以获得关于表面积累的具体过程的有价值的信息，例如关于细胞的粘附。 所述信息在医学/生物学领域尤其重要。