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    Aryloxy-alkyl-dialkylamines
    3.
    发明授权
    Aryloxy-alkyl-dialkylamines 失效
    芳氧基 - 烷基 - 二烷基胺

    公开(公告)号：US06268504B1

    公开(公告)日：2001-07-31

    申请号：US09458317

    申请日：1999-12-10

    申请人： Panolil Raveendranath ,  Joseph Zeldis ,  Galina Vid ,  John R. Potoski ,  Jianxin Ren ,  Silvio Iera

    发明人： Panolil Raveendranath ,  Joseph Zeldis ,  Galina Vid ,  John R. Potoski ,  Jianxin Ren ,  Silvio Iera

    IPC分类号： C07D27704

    CPC分类号： C07D295/088 ,  C07C217/48

    摘要： The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula: wherein: R1 and R2 are, independently, selected from H; C1-C12 alkyl or C1-C6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R3, R4, R5, and R6 are independently selected from H, halogen, —NO2, alkyl, alkoxy, C1-C6 perfluorinated alkyl, OH or the C1-C4 esters or alkyl ethers thereof, —CN, —O—R1, —O—Ar, —S—R1, —S—Ar, —SO—R1, —SO—Ar, —SO2—R1, —SO2—Ar, —CO—R1, —CO—Ar, —CO2—R1, or —CO2—Ar; and Y is selected from a) the moiety: wherein R7 and R8 are independently selected from the group of H, C1-C6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of —O—, —NH—, —N(C1C4 alkyl)—, —N═, and —S(O)n—.

    摘要翻译： 本发明提供了可用于合成生物活性化合物的化合物及其制备方法，具有下式的化合物：其中：R 1和R 2独立地选自H; C1-C12烷基或C1-C6全氟化烷基; X表示离去基团; A是O或S; m为1〜3的整数，优选为2; R 3，R 4，R 5和R 6独立地选自H，卤素，-NO 2，烷基，烷氧基，C 1 -C 6全氟烷基，OH或其C 1 -C 4酯或其烷基醚，-CN，-O-R 1， O-Ar，-S-R 1，-S-Ar，-SO-R 1，-SO-Ar，-SO 2 -R 1，-SO 2 -Ar，-CO-R 1，-CO-Ar，-CO 2 -R -CO 2 -Ar; 并且Y选自a）部分：其中R 7和R 8独立地选自H，C 1 -C 6烷基或苯基; 或b）任选取代的五元，六元或七元饱和的不饱和或部分不饱和的杂环或双环杂环，其含有至多两个选自-O - ， - NH - ， - N（C 1 -C 4烷基） - ， - N =和-S（O）n - 。

    Aryloxy-alkyl-dialkylamines
    4.
    发明授权
    Aryloxy-alkyl-dialkylamines 失效
    芳氧基 - 烷基 - 二烷基胺

    公开(公告)号：US6005102A

    公开(公告)日：1999-12-21

    申请号：US161653

    申请日：1998-09-28

    申请人： Panolil Raveendranath ,  Joseph Zeldis ,  Galina Vid ,  John R. Potoski ,  Jianxin Ren ,  Silvio Iera

    发明人： Panolil Raveendranath ,  Joseph Zeldis ,  Galina Vid ,  John R. Potoski ,  Jianxin Ren ,  Silvio Iera

    IPC分类号： C07C217/48 ,  C07D233/60 ,  C07D295/092 ,  C07D273/06 ,  C07D285/36

    CPC分类号： C07D295/088 ,  C07C217/48

    摘要： The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are, independently, selected from H; C.sub.1 -C.sub.12 alkyl or C.sub.1 -C.sub.6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are independently selected from H, halogen, --NO.sub.2, alkyl, alkoxy, C.sub.1 -C.sub.6 perfluorinated alkyl, OH or the C.sub.1 -C.sub.4 esters or alkyl ethers thereof, --CN, --O--R.sup.1, --O--Ar, --S--R.sup.1, --S--Ar, --SO--R.sup.1, --SO--Ar, --SO.sub.2 --R.sup.1, --SO.sub.2 --Ar, --CO--R.sup.1, --CO--Ar, --CO.sub.2 --R.sup.1, or --CO.sub.2 --Ar; and Y is selected from a) the moiety: ##STR2## wherein R.sub.7 and R.sub.8 are independently selected from the group of H, C.sub.1 -C.sub.6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of --O--, --NH--, --N(C.sub.1 C.sub.4 alkyl)--, --N.dbd., and --S(O).sub.n --.

    摘要翻译： 本发明提供了可用于合成生物活性化合物的化合物及其制备方法，具有下式的化合物：其中：R 1和R 2独立地选自H; C1-C12烷基或C1-C6全氟化烷基; X表示离去基团; A是O或S; m为1〜3的整数，优选为2; R 3，R 4，R 5和R 6独立地选自H，卤素，-NO 2，烷基，烷氧基，C 1 -C 6全氟烷基，OH或其C 1 -C 4酯或其烷基醚，-CN，-O-R 1， O-Ar，-S-R 1，-S-Ar，-SO-R 1，-SO-Ar，-SO 2 -R 1，-SO 2 -Ar，-CO-R 1，-CO-Ar，-CO 2 -R -CO 2 -Ar; 并且Y选自a）部分：其中R 7和R 8独立地选自H，C 1 -C 6烷基或苯基; 或b）任选取代的五元，六元或七元饱和的不饱和或部分不饱和的杂环或双环杂环，其含有至多两个选自-O - ， - NH - ， - N（C 1 -C 4烷基） - ， - N =和-S（O）n - 。

    Aryloxy-alkyl-dialkylamines
    6.
    发明授权
    Aryloxy-alkyl-dialkylamines 失效
    芳氧基 - 烷基 - 二烷基胺

    公开(公告)号：US06242605B1

    公开(公告)日：2001-06-05

    申请号：US09458316

    申请日：1999-12-10

    申请人： Panolil Raveendranath ,  Joseph Zeldis ,  Galina Vid ,  John R. Potoski ,  Jianxin Ren ,  Silvio Iera

    发明人： Panolil Raveendranath ,  Joseph Zeldis ,  Galina Vid ,  John R. Potoski ,  Jianxin Ren ,  Silvio Iera

    IPC分类号： C07D23702

    CPC分类号： C07D295/088 ,  C07C217/48

    摘要： The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula: wherein: R1 and R2 are, independently, selected from H; C1-C12 alkyl or C1-C6 perfluorinated alkyl; X represents a leaving group; A is 0 or S; m is an integer from 1 to 3, preferably 2; R3, R4, R5, and R6 are independently selected from H, halogen, —NO2, alkyl, alkoxy, C1-C6 perfluorinated alkyl, OH or the C1-C4 esters or alkyl ethers thereof, —CN, —O—R1, —O—Ar, —S—R1, —S—Ar, —SO—R1, —SO—Ar, —SO2—R1, —SO2—Ar, —CO—R1, —CO—Ar, —CO2—R1, or —CO2—Ar; and Y is selected from a) the moiety: wherein R7 and R8 are independently selected from the group of H, C1-C6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of —O—, —NH—, —N(C1C4 alkyl)—, —N═, and —S(O)n—.

    摘要翻译： 本发明提供了可用于合成生物活性化合物的化合物及其制备方法，具有下式的化合物：其中：R 1和R 2独立地选自H; C1-C12烷基或C1-C6全氟化烷基; X表示离去基团; A为0或S; m为1〜3的整数，优选为2; R 3，R 4，R 5和R 6独立地选自H，卤素，-NO 2，烷基，烷氧基，C 1 -C 6全氟烷基，OH或其C 1 -C 4酯或其烷基醚，-CN，-O-R 1， O-Ar，-S-R 1，-S-Ar，-SO-R 1，-SO-Ar，-SO 2 -R 1，-SO 2 -Ar，-CO-R 1，-CO-Ar，-CO 2 -R -CO 2 -Ar; 并且Y选自a）部分：其中R 7和R 8独立地选自H，C 1 -C 6烷基或苯基; 或b）任选取代的五元，六元或七元饱和的不饱和或部分不饱和的杂环或双环杂环，其含有至多两个选自-O - ， - NH - ， - N（C 1 -C 4烷基） - ， - N =和-S（O）n - 。

    Process for the purification of substituted benzoxazole compounds
    8.
    发明申请
    Process for the purification of substituted benzoxazole compounds 失效

    公开(公告)号：US20060199967A1

    公开(公告)日：2006-09-07

    申请号：US11369113

    申请日：2006-03-06

    申请人： Silvio Iera

    发明人： Silvio Iera

    IPC分类号： C07D263/60

    CPC分类号： C07D263/57 ,  C07D263/42

    摘要： The present invention provides processes for the purification of substituted benzoxazole compounds, and in particular 2-(3-fluoro-4-hydroxy-phenyl)-7-vinyl-benzooxazol-5-ol. The processes include recrystallizing the compound from a solution comprising acetone and acetonitrile; treating the crude purified product with a clarifying agent in a solution comprising ethyl acetate, and precipitating or triturating the compound from a mixed solvent system.