公开(公告)号：US07345036B2

公开(公告)日：2008-03-18

申请号：US10480569

申请日：2002-06-10

申请人： Simon James Anthony Grove ,  Julia Adam-Worall ,  Minggiang Zhang ,  Robert Gilfillan

发明人： Simon James Anthony Grove ,  Julia Adam-Worall ,  Minggiang Zhang ,  Robert Gilfillan

IPC分类号： A61P25/28

CPC分类号： C07D498/14

摘要： The present invention relates to (pyrido/thieno)-[f]-oxazepine-5-one derivatives having the general Formula (I) or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said derivatives, and to the use of these (pyrido/thieno)-[f]-oxazepine-5-one derivatives in the treatment of neurological diseases and psychiatric disorders which are responsive to enhancement of synaptic responses mediated by AMPA receptors in the central nervous system.

摘要翻译： 本发明涉及具有通式（I）的（吡啶并噻吩并） - [f] - 氧氮杂-5-酮衍生物或其药学上可接受的盐。 本发明还涉及包含所述衍生物的药物组合物，以及这些（吡啶并噻吩并[f] - 氧氮杂-5-酮衍生物在治疗对增强突触反应有反应的神经疾病和精神疾病的用途中的用途） 由AMPA受体介导的中枢神经系统。