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公开(公告)号：US20110076192A1
公开(公告)日：2011-03-31
申请号：US12893742
申请日：2010-09-29
申请人： Simon ROBITAILLE , Sylvie DUFRESNE , Jean-Martin VALLIERES , Cynthia MARTEL , Helene LEBLOND , Nancy DASSIE , Marie-Christine GAGNE , Karine MARTEL , Claudia BEDARD , Bruno TREMBLAY
发明人： Simon ROBITAILLE , Sylvie DUFRESNE , Jean-Martin VALLIERES , Cynthia MARTEL , Helene LEBLOND , Nancy DASSIE , Marie-Christine GAGNE , Karine MARTEL , Claudia BEDARD , Bruno TREMBLAY
CPC分类号： A61L2/202 , A61L2/20 , A61L2/208 , A61L2202/122 , A61L2202/13 , A61L2202/14 , A61L2202/24 , B65D23/001
摘要： A method of sterilizing an article by sequentially exposing the article to hydrogen peroxide and ozone is disclosed. The article is exposed under vacuum first to an evaporated aqueous solution of hydrogen peroxide and subsequently to an ozone containing gas. The exposure is carried out without reducing the water vapor content of the sterilization atmosphere, the water vapor content being derived from the aqueous solvent of the hydrogen peroxide solution and from the decomposition of the hydrogen peroxide into water and oxygen. The complete sterilization process is carried out while the chamber remains sealed and without removal of any component of the sterilization atmosphere. For this purpose, the chamber is initially evacuated to a first vacuum pressure sufficient to cause evaporation of the aqueous hydrogen peroxide at the temperature of the chamber atmosphere. The chamber is then sealed for the remainder of the sterilization process and during all sterilant injection cycles. Keeping the chamber sealed and maintaining the hydrogen peroxide and its decomposition products in the chamber for the subsequent ozone sterilization step results in a synergistic increase in the sterilization efficiency and allows for the use of much lower sterilant amounts and sterilization cycle times than would be expected from using hydrogen peroxide and ozone in combination.
摘要翻译： 公开了通过将制品依次暴露于过氧化氢和臭氧来对制品进行灭菌的方法。 将该制品首先在真空下暴露于蒸发的过氧化氢水溶液中，随后暴露于含臭氧气体。 曝光是在不降低灭菌气氛的水蒸气含量的情况下进行的，水蒸汽含量来自过氧化氢溶液的水性溶剂和由过氧化氢分解成水和氧气。 在室保持密封且不除去灭菌气氛的任何成分的情况下完成灭菌过程。 为此，腔室最初被抽空到第一真空压力，足以在室气氛的温度下引起过氧化氢水溶液的蒸发。 然后将腔室密封用于灭菌过程的剩余部分和所有灭菌剂注射循环期间。 将室密封并将过氧化氢及其分解产物保持在室中用于随后的臭氧消毒步骤导致灭菌效率的协同增加，并允许使用比预期的更低的杀菌剂量和灭菌循环时间 使用过氧化氢和臭氧组合使用。
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公开(公告)号：US20130243649A1
公开(公告)日：2013-09-19
申请号：US13779193
申请日：2013-02-27
IPC分类号： A61L2/20
CPC分类号： A61L2/202 , A61L2/20 , A61L2/208 , A61L2202/122 , A61L2202/13 , A61L2202/14 , A61L2202/24 , B65D23/001
摘要： A method of controlling unwanted condensation of hydrogen peroxide in a sterilization chamber at a preselected temperature is disclosed. The method includes the steps of maintaining the sterilization chamber at a vacuum pressure below the pressure at which hydrogen peroxide will boil at the preselected temperature, evaporating successive pulses of hydrogen peroxide, and injecting the evaporated hydrogen peroxide into the chamber, whereby the volume of each pulse of hydrogen peroxide is less than 75 μL, preferably less than 35 μL, most preferably less than 20 μL. Sterilization results are improved by controlling unwanted condensation of hydrogen peroxide.
摘要翻译： 公开了一种在预定温度下在灭菌室中控制过氧化氢不希望的冷凝的方法。 该方法包括以下步骤：将灭菌室保持在低于过氧化氢在预选温度下沸腾的压力的真空压力，蒸发连续的过氧化氢脉冲，并将蒸发的过氧化氢注入室中，由此每个 过氧化氢的脉冲小于75μL，优选小于35μL，最优选小于20μL。 通过控制过氧化氢的不需要的冷凝来改善灭菌效果。
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公开(公告)号：US20130236356A1
公开(公告)日：2013-09-12
申请号：US13779168
申请日：2013-02-27
IPC分类号： A61L2/20
CPC分类号： A61L2/202 , A61L2/20 , A61L2/208 , A61L2202/122 , A61L2202/13 , A61L2202/14 , A61L2202/24 , B65D23/001
摘要： A method of metering a preselected volume of hydrogen peroxide into a vessel under vacuum is disclosed. The method comprises the steps of connecting a passage of known volume to the vessel under vacuum to evacuate the passage; sealing the passage; connecting the passage to a supply of hydrogen peroxide solution for a time sufficient to draw the hydrogen peroxide solution into the evacuated passage and fill the passage with the hydrogen peroxide solution; sealing the passage; and repeating steps a) to d) until a cumulative volume of fills of the passage is equal to the preselected volume. The volume of the passage is preferably 15 μL to 75 μL. Sterilization is controlled in an economic manner by obviating the need for a means to measure the hydrogen peroxide concentration in the chamber.
摘要翻译： 公开了一种在真空下将预选量的过氧化氢计量到容器中的方法。 该方法包括以下步骤：将已知体积的通道在真空下连接到容器以抽空通道; 密封通道; 将通道连接到过氧化氢溶液供应足够的时间以将过氧化氢溶液抽吸到抽空的通道中并用过氧化氢溶液填充通道; 密封通道; 并重复步骤a）至d），直到通道的累积体积等于预选的体积。 通道的体积优选为15μm至75μm。 通过消除对测量室中过氧化氢浓度的手段的需要，经济地控制灭菌。
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公开(公告)号：US20130236363A1
公开(公告)日：2013-09-12
申请号：US13780464
申请日：2013-02-28
IPC分类号： A61L2/20
CPC分类号： A61L2/202 , A61L2/20 , A61L2/208 , A61L2202/122 , A61L2202/13 , A61L2202/14 , A61L2202/24 , B65D23/001
摘要： A hydrogen peroxide delivery system for a sterilizer having a hydrogen peroxide injection unit and a housing is disclosed. The system includes a cradle for supporting a hydrogen peroxide solution container, a drainage arrangement for aspirating the hydrogen peroxide solution from the container, and a delivery arrangement for supplying the aspirated hydrogen peroxide solution to the hydrogen peroxide injection unit. The drainage arrangement includes a needle for penetrating a seal on the container and extending into the hydrogen peroxide solution in the container. A needle drive moves the needle from an at rest position, wherein the needle is retracted to allow insertion of a new hydrogen peroxide container into the cradle, to a penetrating position wherein the needle penetrates the seal of the container and extends all the way to the bottom of the container to ensure complete drainage of the hydrogen peroxide solution from the container.
摘要翻译： 公开了一种用于具有过氧化氢注入单元和外壳的灭菌器的过氧化氢输送系统。 该系统包括用于支撑过氧化氢溶液容器的支架，用于从容器吸出过氧化氢溶液的排水装置，以及用于将吸入的过氧化氢溶液供应到过氧化氢注入单元的输送装置。 排水装置包括用于穿透容器上的密封并延伸到容器中的过氧化氢溶液中的针。 针驱动器将针从静止位置移动，其中针缩回以允许将新的过氧化氢容器插入到支架中，到达穿透位置，其中针穿透容器的密封并且一直延伸到 容器的底部，以确保从容器中完全排出过氧化氢溶液。
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公开(公告)号：US20130236373A1
公开(公告)日：2013-09-12
申请号：US13780656
申请日：2013-02-28
IPC分类号： A61L2/20
CPC分类号： A61L2/202 , A61L2/20 , A61L2/208 , A61L2202/122 , A61L2202/13 , A61L2202/14 , A61L2202/24 , B65D23/001
摘要： A metering unit is provided for metering hydrogen peroxide into an evacuated vessel, for controlling the concentration of hydrogen peroxide in the vessel. The metering unit includes a body defining a metering passage having a fixed volume and upstream and downstream ends, an upstream connection for connecting the upstream end to a hydrogen peroxide supply, a downstream connection for connecting the downstream end to a hydrogen peroxide vaporizer, an upstream valve for selectively closing the upstream end and a downstream valve for selectively closing the downstream end, and a controller for operating the valves in a non-overlapping and opposite manner for selectively preventing opening of both valves at the same time. With the metering unit of this disclosure, expensive peroxide concentration measurement systems are replaced with an economical monitoring of the number of injection cycles using a passage of fixed volume.
摘要翻译： 提供计量单元，用于将过氧化氢计量到真空容器中，以控制容器中过氧化氢的浓度。 计量单元包括限定具有固定体积和上游和下游端的计量通道的主体，用于将上游端连接到过氧化氢供应的上游连接，用于将下游端连接到过氧化氢蒸发器的下游连接，上游 用于选择性地关闭上游端的阀和用于选择性地关闭下游端的下游阀，以及用于以不重叠和相反的方式操作阀的控制器，用于选择性地防止两个阀同时打开。 利用本公开的计量单元，使用固定体积通过的经济监控注射循环次数来代替昂贵的过氧化物浓度测量系统。
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公开(公告)号：US20130236357A1
公开(公告)日：2013-09-12
申请号：US13779200
申请日：2013-02-27
IPC分类号： A61L2/20
CPC分类号： A61L2/202 , A61L2/20 , A61L2/208 , A61L2202/122 , A61L2202/13 , A61L2202/14 , A61L2202/24 , B65D23/001
摘要： A method of metering of hydrogen peroxide gas into an evacuated sterilization chamber is disclosed. The method includes the steps of continuously monitoring a pressure in the sterilization chamber; connecting a passage of known volume to the evacuated chamber for evacuating the passage; sealing the passage; connecting the evacuated passage to a supply of hydrogen peroxide solution for a time sufficient to draw the hydrogen peroxide solution into and fill the passage; sealing the passage; and repeating those steps until a preselected pressure increase in the sterilization chamber is detected. The pressure increase is preferably 19 Torr. The known volume of the metering passage is preferably between 75 μL and 15 μL to control unwanted condensation of hydrogen peroxide in the sterilization chamber. Expensive peroxide concentration measurement systems are replaced with an economical low cost pressure sensor for control of the hydrogen peroxide concentration.
摘要翻译： 公开了一种将过氧化氢气体计量到抽空的消毒室中的方法。 该方法包括：连续监测灭菌室内的压力; 将已知体积的通道连接到抽真空室以抽出通道; 密封通道; 将抽空的通道连接到过氧化氢溶液供应足以将过氧化氢溶液吸入并填充通道的时间; 密封通道; 并重复这些步骤直到检测到消毒室中的预选压力增加。 压力升高优选为19托。 计量通道的已知体积优选在75μm和15μm之间以控制消毒室中过氧化氢的不期望的冷凝。 昂贵的过氧化物浓度测量系统被替换为经济的低成本压力传感器，用于控制过氧化氢浓度。
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