公开(公告)号：US09594079B2

公开(公告)日：2017-03-14

申请号：US14420023

申请日：2013-08-13

Applicant: Sinvent AS

Inventor： Michal Marek Mielnik ,  Jon Olav Grepstad ,  Ib-Rune Johansen

IPC: G01N31/00 ,  G01N33/53 ,  G01N33/543 ,  B82Y20/00 ,  G01N21/77 ,  G01N21/47

CPC classification number: G01N33/54366 ,  B82Y20/00 ,  G01N21/4788 ,  G01N21/77 ,  G01N21/7743 ,  G01N2021/7763 ,  G01N2021/7773 ,  G01N2021/7789

Abstract: This invention relates to a system and method for detecting target molecules using an optical sensor element including a photonic crystal constituted by a membrane of a chosen transparent material, being provided with a number of defined openings in a chosen pattern, a chosen number of the openings providing capture molecules having a high affinity to target molecules, the pattern being adapted to provide resonance at a chosen wavelength, or range of wavelengths. The system and method also moving a first fluid flow containing target molecules through the openings and after this conducting a second fluid flow containing a second reactant being different from the capture molecules but having a high affinity for the target molecules but a low affinity for other possible molecules in the first flow. By illuminating the sensor element at a chosen wavelength thus obtaining a resonance and imaging means for providing an image of the sensor element it is possible to detect tight leaking from the resonator. Analyzing means may then detect the captured molecules as well as the reactant having reacted with them based on the amount of light leaking from the resonator.

Abstract translation: 本发明涉及一种用于使用包括由所选择的透明材料的膜构成的光子晶体的光学传感器元件检测目标分子的系统和方法，所述光子晶体设置有选定图案中的多个限定的开口，所选数量的开口 提供对靶分子具有高亲和力的捕获分子，所述图案适于在选定的波长或波长范围内提供共振。 该系统和方法还通过开口移动含有目标分子的第一流体流，并且在此之后进行含有与捕获分子不同但对靶分子具有高亲和力但对其它可能性具有低亲和力的第二流体流 分子在第一流。 通过以所选择的波长照亮传感器元件，从而获得谐振和用于提供传感器元件的图像的成像装置，可以检测到从谐振器的紧密泄漏。 然后分析装置可以基于从谐振器泄漏的光量来检测捕获的分子以及与它们反应的反应物。

公开(公告)号：US20150219642A1

公开(公告)日：2015-08-06

申请号：US14420023

申请日：2013-08-13

Applicant: Sinvent AS

Inventor： Michal Marek Mielnik ,  Jon Olav Grepstad ,  Ib-Rune Johansen

IPC: G01N33/543 ,  G01N21/77

CPC classification number: G01N33/54366 ,  B82Y20/00 ,  G01N21/4788 ,  G01N21/77 ,  G01N21/7743 ,  G01N2021/7763 ,  G01N2021/7773 ,  G01N2021/7789

Abstract: This invention relates to a system and method for detecting target molecules using an optical sensor element comprising a photonic crystal constituted by a membrane of a chosen transparent material, being provided with a number of defined openings in a chosen pattern, a chosen number of said openings providing a capture molecules having a high affinity to said target molecules, the pattern being adapted to provide resonance at a chosen wavelength, or range of wavelengths. The system and method also moving a first fluid flow containing target molecules through said openings and after this conducting a second fluid flow containing a second reactant being different from said capture molecules but having a high affinity for the target molecules but a low affinity for other possible molecules in said first flow. By illuminating said sensor element at said chosen wavelength thus obtaining a resonance and imaging means for providing an image of said sensor element it is possible to detect tight leaking from the resonator. Analyzing means may then detect the captured molecules as well as the reactant having reacted with them based on the amount of light leaking from, the resonator.

Abstract translation: 本发明涉及一种用于使用光学传感器元件检测目标分子的系统和方法，所述光学传感器元件包括由所选择的透明材料的膜构成的光子晶体，所述光子晶体以选定的图案设置有多个限定的开口，所选数量的所述开口 提供对所述目标分子具有高亲和力的捕获分子，所述图案适于在选定的波长或波长范围内提供共振。 该系统和方法还通过所述开口移动含有目标分子的第一流体流，并且在此之后进行含有不同于所述捕获分子但对靶分子具有高亲和力但对其它可能性的低亲和力的第二流体流 所述第一流中的分子。 通过以所述选择的波长照亮所述传感器元件，从而获得谐振和用于提供所述传感器元件的图像的成像装置，可以检测从谐振器的紧密泄漏。 然后分析装置可以基于从谐振器泄漏的光量来检测捕获的分子以及与它们反应的反应物。