公开(公告)号：US20220289785A1

公开(公告)日：2022-09-15

申请号：US17387495

申请日：2021-07-28

申请人： Sirna Therapeutics, Inc.

发明人： David TELLERS ,  Steven L. COLLETTI ,  Vadim DUDKIN ,  Jeffrey AARONSON ,  Aaron MOMOSE ,  Thomas Joseph TUCKER ,  Yu YUAN ,  Kathleen B. CALATI ,  Lu TIAN ,  Rubina G. PARMAR ,  Anthony W. SHAW ,  Weimin WANG ,  Rachel Anne STORR ,  Marina BUSUEK ,  Robert A. KOWTONIUK

IPC分类号： C07H15/26 ,  A61K31/7056 ,  A61K31/713 ,  A61K47/54 ,  C12N15/113

摘要： Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from Table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.

公开(公告)号：US20180079769A1

公开(公告)日：2018-03-22

申请号：US15807143

申请日：2017-11-08

申请人： Sirna Therapeutics, Inc.

发明人： David TELLERS ,  Steven L. COLLETTI ,  Vadim DUDKIN ,  Jeffrey AARONSON ,  Aaron MOMOSE ,  Thomas Joseph TUCKER ,  Yu YUAN ,  Kathleen B. CALATI ,  Lu TIAN ,  Rubina G. PARMAR ,  Anthony W. SHAW ,  Weimin WANG ,  Rachel Anne STORR ,  Marina BUSUEK ,  Robert A. KOWTONIUK

IPC分类号： C07H15/26

CPC分类号： C07H15/26 ,  A61K31/7056 ,  A61K31/713 ,  A61K47/549 ,  C12N15/113 ,  C12N2310/17 ,  C12N2310/3513 ,  A61K2300/00

摘要： Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from Table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.

公开(公告)号：US20170306324A1

公开(公告)日：2017-10-26

申请号：US15481942

申请日：2017-04-07

申请人： Sirna Therapeutics, Inc.

发明人： David TELLERS ,  Steven L. COLLETTI ,  Vadim DUDKIN ,  Jeffrey AARONSON ,  Aaron MOMOSE ,  Thomas Joseph TUCKER ,  Yu YUAN ,  Kathleen B. CALATI ,  Lu TIAN ,  Rubina G. PARMAR ,  Anthony W. SHAW ,  Weimin WANG ,  Rachel Anne STORR ,  Marina BUSUEK ,  Robert A. KOWTONIUK

IPC分类号： C12N15/113 ,  A61K31/7056 ,  C07H15/26 ,  A61K31/713

CPC分类号： C07H15/26 ,  A61K31/7056 ,  A61K31/713 ,  A61K47/549 ,  C12N15/113 ,  C12N2310/17 ,  C12N2310/3513 ,  A61K2300/00

摘要： Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from Table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.

公开(公告)号：US20190153016A1

公开(公告)日：2019-05-23

申请号：US16268262

申请日：2019-02-05

申请人： Sirna Therapeutics, Inc.

发明人： David TELLERS ,  Steven L. COLLETTI ,  Vadim DUDKIN ,  Jeffrey AARONSON ,  Aaron MOMOSE ,  Thomas Joseph TUCKER ,  Yu YUAN ,  Kathleen B. CALATI ,  Lu TIAN ,  Rubina G. PARMAR ,  Anthony W. SHAW ,  Weimin WANG ,  Rachel Anne STORR ,  Marina BUSUEK ,  Robert A. KOWTONIUK

IPC分类号： C07H15/26 ,  C12N15/113 ,  A61K31/713 ,  A61K47/54 ,  A61K31/7056

摘要： Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from Table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.

公开(公告)号：US20170233731A1

公开(公告)日：2017-08-17

申请号：US15363490

申请日：2016-11-29

申请人： Sirna Therapeutics, Inc.

发明人： David TELLERS ,  Steven COLLETTI ,  Vadim DUDKIN ,  Norihiro IKEMOTO ,  Hongbiao LIAO ,  Craig PARISH ,  Tao PEI ,  Anthony SHAW ,  Quang TRUONG ,  Lijun WANG ,  Yu YUAN ,  Man ZHU

IPC分类号： C12N15/113

CPC分类号： C12N15/113 ,  A61K47/549 ,  C07H15/26 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/351

摘要： Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; and optionally, 4) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.