公开(公告)号：US20100279879A1

公开(公告)日：2010-11-04

申请号：US12678628

申请日：2008-09-16

申请人： Sitharthan Kamalakaran ,  Robert Lucito ,  James Bruce Hicks ,  Xiaoyue Zhao ,  Jude Kendall

发明人： Sitharthan Kamalakaran ,  Robert Lucito ,  James Bruce Hicks ,  Xiaoyue Zhao ,  Jude Kendall

IPC分类号： C12Q1/68 ,  C40B30/00 ,  C40B40/06 ,  C07H21/04

CPC分类号： C12Q1/6886 ,  C12Q1/6827 ,  C12Q2600/154 ,  C12Q2523/125

摘要： Method for the analysis of breast cancer disorders, comprising determining the genomic methylation status of one or more CpG dinucleotides in a sequence selected from the group of sequences according to SEQ ID NO. 1 to 10 and/or SEQ ID NO. 50 to SEQ ID NO. 60. Optionally, additionally following steps are performed, the one or more results from the methylation status test is input into a classifier that is obtained from a Diagnostic Multi Variate Model, calculating a likelihood as to whether the sample is from a normal tissue or an breast cancer tissue and/or, calculating an associated p-value for the confidence in the prediction.

摘要翻译： 用于分析乳腺癌病症的方法，包括确定一个或多个CpG二核苷酸的基因组甲基化状态，所述序列选自SEQ ID NO。 1至10和/或SEQ ID NO。 50至SEQ ID NO。 可选地，另外执行以下步骤，将来自甲基化状态测试的一个或多个结果输入到从诊断多变量模型获得的分类器中，计算样品是来自正常组织或 乳腺癌组织和/或计算预测中置信度的相关p值。