公开(公告)号：US11872305B2

公开(公告)日：2024-01-16

申请号：US17822756

申请日：2022-08-26

申请人： Slayback Pharma LLC

发明人： Ashish Anilrao Dubewar ,  Amit Anil Charkha ,  Sumitra Ashokkumar Pillai ,  Pradeep Kumar Kare ,  Kumar Swamy Ummiti ,  Shanker Mamidi ,  Mayur Anshiram Adhav

IPC分类号： A01N37/00 ,  A61K31/215 ,  A01N37/12 ,  A01N37/44 ,  A61K31/24 ,  A01N25/00 ,  A61K9/00 ,  A61K47/18 ,  A61K47/10 ,  A61K31/225 ,  A61K31/221 ,  A61K47/12

CPC分类号： A61K9/0019 ,  A61K31/221 ,  A61K31/225 ,  A61K47/10 ,  A61K47/12 ,  A61K47/183

摘要： The present invention relates to injectable pharmaceutical compositions comprising therapeutically effective amount of succinylcholine chloride, one or more pharmaceutically acceptable aqueous solvents, and one or more stabilizing agents selected from aliphatic polyols; lower alkyl alcohols; amino acids having at least one additional amino, carboxyl or hydroxyl group; amino alcohols; and aliphatic dicarboxylic acids having at least one hydroxyl or amino group, or α-β unsaturation. The compositions are stable at room temperature for at least 30 days. Methods of manufacturing the injectable pharmaceutical compositions are also provided. The composition may be provided in a sealed container, e.g., an ampoule, vial and pre-filled syringe, and are suitable for subcutaneous, intravenous or intramuscular administration as an adjunct to general anesthesia, to facilitate tracheal intubation, and/or to provide skeletal muscle relaxation during surgery or mechanical ventilation.

公开(公告)号：US20240156829A1

公开(公告)日：2024-05-16

申请号：US18487330

申请日：2023-10-16

申请人： Slayback Pharma LLC

发明人： Ashish Anilrao Dubewar ,  Rahul Dhutaji Bhise ,  Shanker Mamidi ,  Mahadeo Vasant Mahadik ,  Sumitra Ashokkumar Pillai ,  Satheesh Balasubramanian ,  Kumar Swamy Ummiti ,  Mayur Anshiram Adhav ,  Praveen Kumar Subbappa

IPC分类号： A61K31/5377 ,  A61K9/00 ,  A61K9/107 ,  A61K47/12 ,  A61K47/26 ,  A61K47/44

CPC分类号： A61K31/5377 ,  A61K9/0019 ,  A61K9/107 ,  A61K47/12 ,  A61K47/26 ,  A61K47/44

摘要： The present invention relates to stable pharmaceutical compositions for parenteral administration comprising aprepitant. The present invention further relates to a method for manufacturing the composition as well as to the use of these compositions. Also included are stable pharmaceutical compositions for parenteral administration comprising aprepitant and palonosetron. The pharmaceutical compositions are stable oil-in-water emulsions for parenteral administration and are particularly useful for the prevention and control of acute and delayed chemotherapy-induced nausea and vomiting (CINV), for the prevention of postoperative nausea and vomiting (PONV), and/or for the prevention of radiation induced nausea and vomiting (RINV).

公开(公告)号：US20240108571A1

公开(公告)日：2024-04-04

申请号：US18528684

申请日：2023-12-04

申请人： Slayback Pharma LLC.

发明人： Ashish Anilrao Dubewar ,  Amit Anil Charkha ,  Sumitra Ashokkumar Pillai ,  Pradeep Kumar Kare ,  Kumar Swamy Ummiti ,  Shanker Mamidi ,  Mayur Anshiram Adhav

IPC分类号： A61K9/00 ,  A61K31/221 ,  A61K31/225 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18

CPC分类号： A61K9/0019 ,  A61K31/221 ,  A61K31/225 ,  A61K47/10 ,  A61K47/12 ,  A61K47/183

摘要： The present invention relates to injectable pharmaceutical compositions comprising therapeutically effective amount of succinylcholine chloride, one or more pharmaceutically acceptable aqueous solvents, and one or more stabilizing agents selected from aliphatic polyols; lower alkyl alcohols; amino acids having at least one additional amino, carboxyl or hydroxyl group; amino alcohols; and aliphatic dicarboxylic acids having at least one hydroxyl or amino group, or α-β unsaturation. The compositions are stable at room temperature for at least 30 days. Methods of manufacturing the injectable pharmaceutical compositions are also provided. The composition may be provided in a sealed container, e.g., an ampoule, vial and pre-filled syringe, and are suitable for subcutaneous, intravenous or intramuscular administration as an adjunct to general anesthesia, to facilitate tracheal intubation, and/or to provide skeletal muscle relaxation during surgery or mechanical ventilation.

公开(公告)号：US20230091021A1

公开(公告)日：2023-03-23

申请号：US17822756

申请日：2022-08-26

申请人： Slayback Pharma LLC

发明人： Ashish Anilrao Dubewar ,  Amit Anil Charkha ,  Sumitra Ashokkumar Pillai ,  Pradeep Kumar Kare ,  Kumar Swamy Ummiti ,  Shanker Mamidi ,  Mayur Anshtram Adhav

IPC分类号： A61K31/221 ,  A61K9/00 ,  A61K47/10 ,  A61K47/18 ,  A61K47/12

摘要： The present invention relates to injectable pharmaceutical compositions comprising therapeutically effective amount of succinylcholine chloride, one or more pharmaceutically acceptable aqueous solvents, and one or more stabilizing agents selected from aliphatic polyols; lower alkyl alcohols; amino acids having at least one additional amino, carboxyl or hydroxyl group; amino alcohols; and aliphatic dicarboxylic acids having at least one hydroxyl or amino group, or α-β unsaturation. The compositions are stable at room temperature for at least 30 days. Methods of manufacturing the injectable pharmaceutical compositions are also provided. The composition may be provided in a sealed container, e.g., an ampoule, vial and pre-filled syringe, and are suitable for subcutaneous, intravenous or intramuscular administration as an adjunct to general anesthesia, to facilitate tracheal intubation, and/or to provide skeletal muscle relaxation during surgery or mechanical ventilation.

公开(公告)号：US20230086729A1

公开(公告)日：2023-03-23

申请号：US17822399

申请日：2022-08-25

申请人： Slayback Pharma LLC

发明人： Ashish Anilrao Dubewar ,  Amit Anil Charkha ,  Sumitra Ashokkumar Pillai ,  Pradeep Kumar Kare ,  Kumar Swamy Ummiti ,  Shanker Mamidi ,  Mayur Anshtram Adhav

IPC分类号： A61K9/00 ,  A61K31/225 ,  A61K47/10 ,  A61K47/18

摘要： The present invention relates to injectable pharmaceutical compositions comprising therapeutically effective amount of succinylcholine chloride, one or more pharmaceutically acceptable aqueous solvents, and one or more stabilizing agents selected from aliphatic polyols; lower alkyl alcohols; amino acids having at least one additional amino, carboxyl or hydroxyl group; amino alcohols; and aliphatic dicarboxylic acids having at least one hydroxyl or amino group, or α-β unsaturation. The compositions are stable at room temperature for at least 30 days. Methods of manufacturing the injectable pharmaceutical compositions are also provided. The composition may be provided in a sealed container, e.g., an ampoule, vial and pre-filled syringe, and are suitable for subcutaneous, intravenous or intramuscular administration as an adjunct to general anesthesia, to facilitate tracheal intubation, and/or to provide skeletal muscle relaxation during surgery or mechanical ventilation.

公开(公告)号：US20190262314A1

公开(公告)日：2019-08-29

申请号：US16276885

申请日：2019-02-15

申请人： SLAYBACK PHARMA LLC

发明人： Ashish Anil Dubewar ,  Pradeep Kumar Kare ,  Kumar Swamy Ummiti ,  Ajay Kumar Singh

IPC分类号： A61K31/4174 ,  A61K47/20 ,  A61K9/00 ,  A61K9/08 ,  A61K47/02 ,  A61J1/14

摘要： The present invention provides stable, ready-to-use pharmaceutical compositions, comprising dexmedetomidine or a pharmaceutically acceptable salt thereof, one or more pharmaceutically acceptable excipients, and a pharmaceutically acceptable liquid vehicle, where the composition is provided in a sealed container that comprises a cyclic olefin polymer. The present invention also provides ready-to-use pharmaceutical compositions comprising dexmedetomidine or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable liquid vehicle and an antioxidant and/or stabilizer, such as L-methionine. These solutions were found to be stable over the shelf life of the product. Other aspects of the invention relate to methods for making such compositions, as well as methods of using such compositions for perioperative care of a patient or for sedation.