公开(公告)号：US20090214530A1

公开(公告)日：2009-08-27

申请号：US12174215

申请日：2008-07-16

申请人： Soo Kie Kim ,  Seung Kyu Park ,  Su Jung Park ,  Hyun Chul Cho

发明人： Soo Kie Kim ,  Seung Kyu Park ,  Su Jung Park ,  Hyun Chul Cho

IPC分类号： A61K31/7088 ,  A61K39/395 ,  A61P35/00

CPC分类号： A61K39/39 ,  A61K39/12 ,  A61K39/292 ,  A61K2039/55505 ,  A61K2039/55561 ,  C12N2730/10134

摘要： The present invention relates to a modified CpG oligodeoxynucleotide (ODN) which is prepared by coupling a consecutive sequence of deoxyribothymine (dT) to the 3′-terminus of CpG ODN having immunoregularory function, thereby improving immunoactivity of splenocytes, macrophages and peripheral mononuclear cells, and therefore, can be effectively used as a vaccine adjuvant for preventing and treating hepatitis B or an anticancer agent. Since the phosphorothioate CpG ODN having the consecutive sequence of dT at its 3′-terminus shows high activity inducing Th-1 immune response and does not elicit in vivo toxicity with guaranteeing its safety, it can be effectively used as a vaccine adjuvant.

摘要翻译： 本发明涉及通过将连续的脱氧胸腺嘧啶（dT）序列与具有免疫赋形功能的CpG ODN的3'末端偶联制备的修饰的CpG寡脱氧核苷酸（ODN），从而提高脾细胞，巨噬细胞和外周单核细胞的免疫活性， 因此可以有效地用作预防和治疗乙型肝炎或抗癌剂的疫苗佐剂。 由于在其3'末端具有dT连续序列的硫代磷酸酯CpG ODN显示高活性诱导Th-1免疫应答，并且不引起体内毒性并保证其安全性，因此可有效地用作疫苗佐剂。

公开(公告)号：US07408050B2

公开(公告)日：2008-08-05

申请号：US10920181

申请日：2004-08-18

申请人： Soo Kie Kim ,  Seung Kyu Park ,  Su Jung Park ,  Hyun Chul Cho

发明人： Soo Kie Kim ,  Seung Kyu Park ,  Su Jung Park ,  Hyun Chul Cho

IPC分类号： C07H21/02 ,  A61K51/00 ,  A61K47/00 ,  A61K39/00

CPC分类号： A61K39/39 ,  A61K39/12 ,  A61K39/292 ,  A61K2039/55505 ,  A61K2039/55561 ,  C12N2730/10134

摘要： The present invention relates to a modified CpG oligodeoxynucleotide (ODN) which is prepared by coupling a consecutive sequence of deoxyribothymine (dT) to the 3′-terminus of CpG ODN having immunoregularory function, thereby improving immunoactivity of splenocytes, macrophages and peripheral mononuclear cells, and therefore, can be effectively used as a vaccine adjuvant for preventing and treating hepatitis B or an anti-cancer agent. Since the phosphorothioate CpG ODN having the consecutive sequence of dT at its 3′-terminus shows high activity inducing Th-1 immune response and does not elicit in vivo toxicity with guaranteeing its safety, it can be effectively used as a vaccine adjuvant.

摘要翻译： 本发明涉及通过将连续的脱氧胸腺嘧啶（dT）序列与具有免疫赋形功能的CpG ODN的3'末端偶联制备的修饰的CpG寡脱氧核苷酸（ODN），从而提高脾细胞，巨噬细胞和外周单核细胞的免疫活性， 因此可以有效地用作预防和治疗乙型肝炎或抗癌剂的疫苗佐剂。 由于在其3'末端具有dT连续序列的硫代磷酸酯CpG ODN显示高活性诱导Th-1免疫应答，并且不引起体内毒性并保证其安全性，因此可有效地用作疫苗佐剂。

公开(公告)号：USD524014S1

公开(公告)日：2006-07-04

申请号：US29214989

申请日：2004-10-13

申请人： Su Jung Park

设计人： Su Jung Park

公开(公告)号：US08045104B2

公开(公告)日：2011-10-25

申请号：US11513271

申请日：2006-08-31

申请人： Suk Ho Cho ,  Su Jung Park ,  Jin Ho Kim

发明人： Suk Ho Cho ,  Su Jung Park ,  Jin Ho Kim

IPC分类号： G02F1/1333 ,  G02F1/1343

CPC分类号： G02F1/134363 ,  G02F1/133512

摘要： A liquid crystal display and a method of manufacturing the same that can reduce the increase in the black level due to light leakage, without reducing the aperture ratio while improving the contrast ratio. The liquid crystal display includes a TFT array substrate comprising a data line, a pixel electrode and a common electrode, and the data line, the pixel electrode and the common electrode have at least one bent structure; a color filter array substrate opposite to the TFT array substrate, the color filter array substrate comprising a black matrix covering an area corresponding to at least the data line and the common electrode; and a liquid crystal layer formed between the TFT array substrate and the color filter array substrate, wherein the black matrix comprises a first black matrix line covering an area where light leakage is minimal, and a second black matrix line covering an area where light leakage is excessive, the second black matrix having a line width larger than a line width of the first black matrix.

摘要翻译： 一种液晶显示器及其制造方法，可以在不降低开口率同时提高对比度的同时，减少由于漏光引起的黑电平的增加。 液晶显示器包括包括数据线，像素电极和公共电极的TFT阵列基板，并且数据线，像素电极和公共电极具有至少一个弯曲结构; 与所述TFT阵列基板相对的滤色器阵列基板，所述滤色器阵列基板包括覆盖至少所述数据线和所述公共电极的区域的黑矩阵; 以及形成在TFT阵列基板和滤色器阵列基板之间的液晶层，其中黑矩阵包括覆盖漏光最小的区域的第一黑矩阵线，以及覆盖漏光的区域的第二黑矩阵线 第二黑矩阵的线宽大于第一黑矩阵的线宽。