公开(公告)号：US20200010576A1

公开(公告)日：2020-01-09

申请号：US16329423

申请日：2016-09-05

申请人： Sorbonne Universite ,  Centre National De La Recherche Scientifique ,  Institut National De La Sante Et De La Recherche Medicale (INSERM) ,  Assistance Publique - Hopitaux De Paris ,  Universite Paris Descartes

发明人： Matthieu SOLLOGOUB ,  Vincent CALVEZ ,  Anne-Geneviève MARCELIN ,  Laurent BOUTEILLER ,  Mickaël MENAND ,  Pierre EVENOU ,  Adélie GOTHLAND ,  Dmitri COLESNIC ,  Julien ROSSIGNOL

IPC分类号： C08B37/16 ,  A61K47/69 ,  C12N15/113

摘要： The invention relates to a capped cyclodextrin-hydrophobic moiety conjugate, to a supramolecular polymer formed of capped cyclodextrin-hydrophobic moiety conjugates according to the invention and to a siRNA-cyclodextrin complex comprising a supramolecular polymer according to the invention. The invention also relates to a method for manufacturing the capped cyclodextrin-hydrophobic moiety conjugate, the supramolecular polymer, the siRNA-cyclodextrin complex according to the invention. The capped cyclodextrin-hydrophobic moiety conjugate of the invention comprises a capped cyclodextrin group and at least one hydrophobic moiety bound by a first linker to one of the carbon atoms of the cap. The invention can be used for various applications in particular in the pharmaceutical field.