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公开(公告)号：US11427534B1
公开(公告)日：2022-08-30
申请号：US17393144
申请日：2021-08-03
发明人： Kristin Patterson , Jiping Liu , Ricky Wayne Couch , Peter Gregory Varlashkin , Mai Li , Yonghong Gan
摘要： The present disclosure relates to: a) crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, h) pharmaceutical compositions comprising one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, one or more pharmaceutically acceptable carriers; c) methods of treating a tumor a cancer, or a Rasopathy disorder by administering one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to a subject in need thereof; and methods of producing essentially pure Form IV of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide.
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公开(公告)号：US11084780B1
公开(公告)日：2021-08-10
申请号：US17177966
申请日：2021-02-17
发明人： Kristin Patterson , Jiping Liu , Ricky Wayne Couch , Peter Gregory Varlashkin , Mai Li , Yonghong Gan
IPC分类号： A61K31/16 , C07C231/00 , A61P35/00 , C07C259/10 , A61K9/00 , A61K9/20 , A61K9/48
摘要： The present disclosure relates to a) crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide; b) pharmaceutical compositions comprising one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, one or more pharmaceutically acceptable carriers; c) methods of treating a tumor a cancer, or a Rasopathy disorder by administering one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to a subject in need thereof, and methods of producing essentially pure Form IV of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide.
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公开(公告)号：US11884610B2
公开(公告)日：2024-01-30
申请号：US17806821
申请日：2022-06-14
发明人： Kristin Patterson , Jiping Liu , Ricky Wayne Couch , Peter Gregory Varlashkin , Mai Li , Yonghong Gan
CPC分类号： C07C259/10 , A61K9/0095 , A61K9/2013 , A61K9/2054 , A61K9/4825 , A61K9/4858 , A61K9/4866 , C07B2200/13
摘要： The present disclosure relates to: a) crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide; b) pharmaceutical compositions comprising one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, one or more pharmaceutically acceptable carriers; c) methods of treating a tumor a cancer, or a Rasopathy disorder by administering one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to a subject in need thereof; and methods of producing essentially pure Form IV of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide.
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