公开(公告)号：US20230414627A1

公开(公告)日：2023-12-28

申请号：US18307718

申请日：2023-04-26

Applicant: Spruce Biosciences, Inc.

Inventor： Alexis HOWERTON ,  Hal GERBER ,  Michael HUANG

IPC: A61K31/5377 ,  A61P5/24 ,  A61K31/573 ,  A61K9/48 ,  A61P5/00 ,  A61K9/14 ,  C07D487/04 ,  A61P5/38

CPC classification number: A61K31/5377 ,  A61P5/24 ,  A61K31/573 ,  A61K9/4825 ,  A61K9/48 ,  A61P5/00 ,  A61K9/14 ,  C07D487/04 ,  A61P5/38

Abstract: The present invention provides novel pharmaceutical compositions comprising -(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).

公开(公告)号：US20220143037A1

公开(公告)日：2022-05-12

申请号：US17586228

申请日：2022-01-27

Applicant: Spruce Biosciences, Inc.

Inventor： Alexis HOWERTON ,  Hal GERBER ,  Michael HUANG

IPC: A61K31/5377 ,  A61P5/00 ,  A61K9/14 ,  A61K9/48 ,  A61P5/24 ,  A61K31/573 ,  C07D487/04 ,  A61P5/38

Abstract: The present invention provides novel pharmaceutical compositions comprising -(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).

公开(公告)号：US20210015827A1

公开(公告)日：2021-01-21

申请号：US17063592

申请日：2020-10-05

Applicant: Spruce Biosciences, Inc.

Inventor： Alexis HOWERTON ,  Hal GERBER ,  Michael HUANG

IPC: A61K31/5377 ,  A61P5/00 ,  A61K9/14 ,  A61K9/48 ,  A61P5/24 ,  A61K31/573 ,  C07D487/04

Abstract: The present invention provides novel pharmaceutical compositions comprising -(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).

公开(公告)号：US20210361664A1

公开(公告)日：2021-11-25

申请号：US16639541

申请日：2018-08-14

Applicant: Spruce Biosciences, Inc.

Inventor： Alexis HOWERTON ,  Hal GERBER ,  Michael HUANG

IPC: A61K31/5377 ,  A61K31/573 ,  A61P5/38

Abstract: The present invention provides novel pharmaceutical compositions comprising -(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).

公开(公告)号：US20210322431A1

公开(公告)日：2021-10-21

申请号：US17359414

申请日：2021-06-25

Applicant: Spruce Biosciences, Inc.

Inventor： Alexis HOWERTON ,  Hal GERBER ,  Michael HUANG

IPC: A61K31/5377 ,  A61P5/00 ,  A61K9/14 ,  A61K9/48 ,  A61P5/24 ,  A61K31/573 ,  C07D487/04

Abstract: The present invention provides novel pharmaceutical compositions comprising -(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).

公开(公告)号：US20250064812A1

公开(公告)日：2025-02-27

申请号：US18941832

申请日：2024-11-08

Applicant: Spruce Biosciences, Inc.

Inventor： Alexis HOWERTON ,  Hal GERBER

IPC: A61K31/519 ,  A61K9/00 ,  A61K9/20 ,  A61K9/48 ,  A61K45/06 ,  A61P5/06 ,  A61P5/08

Abstract: Provided herein are compounds and pharmaceutical compositions for the prevention and treatment of testicular adrenal rest tumors (TART) or ovarian adrenal rest tumors (OART).

公开(公告)号：US20230321112A1

公开(公告)日：2023-10-12

申请号：US18078649

申请日：2022-12-09

Applicant: Spruce Biosciences, Inc.

Inventor： Alexis HOWERTON ,  Hal GERBER ,  Michael HUANG

IPC: A61K31/5377 ,  A61P5/00 ,  A61K9/14 ,  A61K9/48 ,  A61P5/24 ,  A61K31/573 ,  C07D487/04 ,  A61P5/38

CPC classification number: A61K31/5377 ,  A61P5/00 ,  A61K9/14 ,  A61K9/4825 ,  A61K9/48 ,  A61P5/24 ,  A61K31/573 ,  C07D487/04 ,  A61P5/38

Abstract: The present invention provides novel pharmaceutical compositions comprising -(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).

公开(公告)号：US20210038604A1

公开(公告)日：2021-02-11

申请号：US17081694

申请日：2020-10-27

Applicant: SPRUCE BIOSCIENCES, INC.

Inventor： Alexis HOWERTON ,  Hal GERBER

IPC: A61K31/519

Abstract: Provided herein are compounds and pharmaceutical compositions for the prevention and treatment of testicular adrenal rest tumors (TART) or ovarian adrenal rest tumors (OART).

公开(公告)号：US20190262349A1

公开(公告)日：2019-08-29

申请号：US16388620

申请日：2019-04-18

Applicant: SPRUCE BIOSCIENCES, INC.

Inventor： Alexis HOWERTON ,  Hal GERBER ,  Michael HUANG

IPC: A61K31/5377 ,  A61K9/14 ,  A61K9/48 ,  A61P5/00

Abstract: The present invention provides novel pharmaceutical compositions comprising -(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).

公开(公告)号：US20220211711A1

公开(公告)日：2022-07-07

申请号：US17667285

申请日：2022-02-08

Applicant: Spruce Biosciences, Inc.

Inventor： Alexis HOWERTON ,  Hal GERBER

IPC: A61K31/519

Abstract: Provided herein are compounds and pharmaceutical compositions for the prevention and treatment of testicular adrenal rest tumors (TART) or ovarian adrenal rest tumors (OART).