公开(公告)号：US09605025B2

公开(公告)日：2017-03-28

申请号：US14131275

申请日：2012-07-06

申请人： Stéphane Dedieu ,  Nicolas Floquet ,  Laurent Martiny ,  Christophe Schneider ,  Albin Jeanne ,  Emilie Sick ,  Manuel Dauchez

发明人： Stéphane Dedieu ,  Nicolas Floquet ,  Laurent Martiny ,  Christophe Schneider ,  Albin Jeanne ,  Emilie Sick ,  Manuel Dauchez

IPC分类号： C07K7/08 ,  C07K7/06 ,  C07K7/64 ,  C07K14/78 ,  A61K38/00

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/78

摘要： Antagonist peptide of the bond between CD47 and a protein belonging to the thrombospondin family has the sequence S1 R1-R2-R3-S-Q-L-L-K-G-R4-R5-R6 and interacts specifically with the C-terminal end of the TSP, at the site of the bond between the TSP and the CD47 receptor. Interaction between the CD47 receptor and the protein is prevented. The peptide can be used in the context of cancer treatments.

公开(公告)号：US20140296477A1

公开(公告)日：2014-10-02

申请号：US14131275

申请日：2012-07-06

申请人： Stéphane Dedieu ,  Nicolas Floquet ,  Laurent Martiny ,  Christophe Schneider ,  Albin Jeanne ,  Emilie Sick ,  Manuel Dauchez

发明人： Stéphane Dedieu ,  Nicolas Floquet ,  Laurent Martiny ,  Christophe Schneider ,  Albin Jeanne ,  Emilie Sick ,  Manuel Dauchez

IPC分类号： C07K7/08 ,  C07K7/64 ,  C07K7/06

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/78

摘要： Antagonist peptide of the bond between CD47 and a protein belonging to the thrombospondin family has the sequence S1 R1-R2-R3-S-Q-L-L-K-G-R4-R5-R6 and interacts specifically with the C-terminal end of the TSP, at the site of the bond between the TSP and the CD47 receptor. Interaction between the CD47 receptor and the protein is prevented. The peptide can be used in the context of cancer treatments.

摘要翻译： CD47与属于血小板反应蛋白家族的蛋白质之间的键的拮抗肽具有序列S1 R1-R2-R3-SQLLKG-R4-R5-R6，并与TSP的C末端特异性相互作用 TSP与CD47受体之间的结合。 防止CD47受体与蛋白质之间的相互作用。 该肽可用于癌症治疗的上下文中。