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公开(公告)号：US09133214B2
公开(公告)日：2015-09-15
申请号：US13371837
申请日：2012-02-13
申请人： Stéphanie Blanchard , Kantharaj Ethirajulu , Cheng Hsia Angeline Lee , Harish Kumar Mysore Nagaraj , Anders Poulsen , Eric T. Sun , Yee Ling Evelyn Tan , Ee Ling Teo , Anthony Deodaunia William
发明人： Stéphanie Blanchard , Kantharaj Ethirajulu , Cheng Hsia Angeline Lee , Harish Kumar Mysore Nagaraj , Anders Poulsen , Eric T. Sun , Yee Ling Evelyn Tan , Ee Ling Teo , Anthony Deodaunia William
IPC分类号： C07D498/06 , C07D498/08 , C07D498/16 , C07D498/18 , C07D515/16 , C07D515/18 , A61K31/519
CPC分类号： A61K31/519 , A61K31/5377 , C07D498/06 , C07D498/08 , C07D498/16 , C07D498/18 , C07D515/16 , C07D515/18
摘要： The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to heteroalkyl linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumors and cancers as well as other conditions or disorders associated with kinases.
摘要翻译： 本发明涉及可用作抗增殖剂的嘧啶化合物。 更具体地，本发明涉及杂烷基连接和取代的嘧啶化合物，其制备方法，含有这些化合物的药物组合物和这些化合物在治疗增殖性疾病中的用途。 这些化合物可用作治疗许多增殖性疾病（包括肿瘤和癌症）以及与激酶相关的其它病症或病症的药物。
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公开(公告)号：US20090258886A1
公开(公告)日：2009-10-15
申请号：US12093874
申请日：2006-11-15
申请人： Stephanie Blanchard , Kantharaj Ethirajulu , Cheng Hsia Angeline Lee , Harish Kumar Mysore Nagaraj , Anders Poulsen , Eric T. Sun , Yee Ling Evelyn Tan , Ee Ling Teo , Anthony Deodaunia William
发明人： Stephanie Blanchard , Kantharaj Ethirajulu , Cheng Hsia Angeline Lee , Harish Kumar Mysore Nagaraj , Anders Poulsen , Eric T. Sun , Yee Ling Evelyn Tan , Ee Ling Teo , Anthony Deodaunia William
IPC分类号： A61K31/553 , C07D487/04 , A61P35/00
CPC分类号： A61K31/519 , A61K31/5377 , C07D498/06 , C07D498/08 , C07D498/16 , C07D498/18 , C07D515/16 , C07D515/18
摘要： The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to heteroalkyl linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other conditions or disorders associated with kinases.
摘要翻译： 本发明涉及可用作抗增殖剂的嘧啶化合物。 更具体地，本发明涉及杂烷基连接和取代的嘧啶化合物，其制备方法，含有这些化合物的药物组合物和这些化合物在治疗增殖性疾病中的用途。 这些化合物可用作治疗许多增殖性疾病（包括肿瘤和癌症）以及与激酶相关的其它病症或病症的药物。
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公开(公告)号：US08143255B2
公开(公告)日：2012-03-27
申请号：US12093874
申请日：2006-11-15
申请人： Stephanie Blanchard , Kantharaj Ethirajulu , Cheng Hsia Angeline Lee , Harish Kumar Mysore Nagaraj , Anders Poulsen , Eric T. Sun , Yee Ling Evelyn Tan , Ee Ling Teo , Anthony Deodaunia William
发明人： Stephanie Blanchard , Kantharaj Ethirajulu , Cheng Hsia Angeline Lee , Harish Kumar Mysore Nagaraj , Anders Poulsen , Eric T. Sun , Yee Ling Evelyn Tan , Ee Ling Teo , Anthony Deodaunia William
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D471/04 , C07D471/22 , C07D487/04 , C07D239/00 , C07D239/70 , C07D471/00 , C07D487/00
CPC分类号： A61K31/519 , A61K31/5377 , C07D498/06 , C07D498/08 , C07D498/16 , C07D498/18 , C07D515/16 , C07D515/18
摘要： The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to heteroalkyl linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumors and cancers as well as other conditions or disorders associated with kinases.
摘要翻译： 本发明涉及可用作抗增殖剂的嘧啶化合物。 更具体地，本发明涉及杂烷基连接和取代的嘧啶化合物，其制备方法，含有这些化合物的药物组合物和这些化合物在治疗增殖性疾病中的用途。 这些化合物可用作治疗许多增殖性疾病（包括肿瘤和癌症）以及与激酶相关的其它病症或病症的药物。
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公开(公告)号：US20120142680A1
公开(公告)日：2012-06-07
申请号：US13371837
申请日：2012-02-13
申请人： Stephanie Blanchard , Kantharaj Ethirajulu , Cheng Hsia Angeline Lee , Harish Kumar Mysore Nagaraj , Anders Poulsen , Eric T. Sun , Yee Ling Evelyn Tan , Ee Ling Teo , Anthony Deodaunia William
发明人： Stephanie Blanchard , Kantharaj Ethirajulu , Cheng Hsia Angeline Lee , Harish Kumar Mysore Nagaraj , Anders Poulsen , Eric T. Sun , Yee Ling Evelyn Tan , Ee Ling Teo , Anthony Deodaunia William
IPC分类号： A61K31/5377 , A61K31/529 , A61P35/00 , A61P35/02 , A61P9/10 , A61P27/02 , A61P7/00 , A61P9/04 , A61P7/02 , A61P9/12 , A61P9/00 , C12N9/99 , A61P25/28
CPC分类号： A61K31/519 , A61K31/5377 , C07D498/06 , C07D498/08 , C07D498/16 , C07D498/18 , C07D515/16 , C07D515/18
摘要： The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to heteroalkyl linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other conditions or disorders associated with kinases.
摘要翻译： 本发明涉及可用作抗增殖剂的嘧啶化合物。 更具体地，本发明涉及杂烷基连接和取代的嘧啶化合物，其制备方法，含有这些化合物的药物组合物和这些化合物在治疗增殖性疾病中的用途。 这些化合物可用作治疗许多增殖性疾病（包括肿瘤和癌症）以及与激酶相关的其它病症或病症的药物。
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公开(公告)号：US08153632B2
公开(公告)日：2012-04-10
申请号：US12093867
申请日：2006-11-15
申请人： Stephanie Blanchard , Cheng Hsia Angeline Lee , Harish Kumar Mysore Nagaraj , Anders Poulsen , Eric T. Sun , Yee Ling Evelyn Tan , Anthony Deodaunia William
发明人： Stephanie Blanchard , Cheng Hsia Angeline Lee , Harish Kumar Mysore Nagaraj , Anders Poulsen , Eric T. Sun , Yee Ling Evelyn Tan , Anthony Deodaunia William
IPC分类号： A61K31/495 , C07D491/00
CPC分类号： A61K31/519 , A61K31/5377 , C07D498/06 , C07D498/08 , C07D498/16 , C07D498/18 , C07D515/16 , C07D515/18
摘要： The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to oxygen linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumors and cancers as well as other disorders or conditions related to or associated with kinases.
摘要翻译： 本发明涉及可用作抗增殖剂的嘧啶化合物。 更具体地，本发明涉及氧连接和取代的嘧啶化合物，其制备方法，含有这些化合物的药物组合物和这些化合物在治疗增殖性疾病中的用途。 这些化合物可用作治疗许多增殖性疾病（包括肿瘤和癌症）以及与激酶相关或与激酶相关的其它病症或病症的药物。
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公开(公告)号：US08415338B2
公开(公告)日：2013-04-09
申请号：US13438989
申请日：2012-04-04
申请人： Stephanie Blanchard , Cheng Hsia Angeline Lee , Harish Kumar Mysore Nagaraj , Anders Poulsen , Eric T. Sun , Yee Ling Evelyn Tan , Anthony Deodaunia William
发明人： Stephanie Blanchard , Cheng Hsia Angeline Lee , Harish Kumar Mysore Nagaraj , Anders Poulsen , Eric T. Sun , Yee Ling Evelyn Tan , Anthony Deodaunia William
IPC分类号： A61K31/33 , C07D273/00
CPC分类号： A61K31/519 , A61K31/5377 , C07D498/06 , C07D498/08 , C07D498/16 , C07D498/18 , C07D515/16 , C07D515/18
摘要： The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to oxygen linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumors and cancers as well as other disorders or conditions related to or associated with kinases.
摘要翻译： 本发明涉及可用作抗增殖剂的嘧啶化合物。 更具体地，本发明涉及氧连接和取代的嘧啶化合物，其制备方法，含有这些化合物的药物组合物和这些化合物在治疗增殖性疾病中的用途。 这些化合物可用作治疗许多增殖性疾病（包括肿瘤和癌症）以及与激酶相关或与激酶相关的其它病症或病症的药物。
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公开(公告)号：US20090075999A1
公开(公告)日：2009-03-19
申请号：US12093867
申请日：2006-11-15
申请人： Stephanie Blanchard , Cheng Hsia Angeline Lee , Harish Kumar Mysore Nagaraj , Anders Poulsen , Eric T. Sun , Yee Ling Evelyn Tan , Anthony Deodaunia William
发明人： Stephanie Blanchard , Cheng Hsia Angeline Lee , Harish Kumar Mysore Nagaraj , Anders Poulsen , Eric T. Sun , Yee Ling Evelyn Tan , Anthony Deodaunia William
IPC分类号： A61K31/5377 , C07D498/06 , C12N9/99 , A61K31/519
CPC分类号： A61K31/519 , A61K31/5377 , C07D498/06 , C07D498/08 , C07D498/16 , C07D498/18 , C07D515/16 , C07D515/18
摘要： The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to oxygen linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with kinases.
摘要翻译： 本发明涉及可用作抗增殖剂的嘧啶化合物。 更具体地，本发明涉及氧连接和取代的嘧啶化合物，其制备方法，含有这些化合物的药物组合物和这些化合物在治疗增殖性疾病中的用途。 这些化合物可用作治疗许多增殖性疾病（包括肿瘤和癌症）以及与激酶相关或与激酶相关的其它病症或病症的药物。
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公开(公告)号：US20120196855A1
公开(公告)日：2012-08-02
申请号：US13438989
申请日：2012-04-04
申请人： Stephanie Blanchard , Cheng Hsia Angeline Lee , Harish Kumar Mysore Nagaraj , Anders Poulsen , Eric T. Sun , Yee Ling Evelyn Tan , Anthony Deodaunia William
发明人： Stephanie Blanchard , Cheng Hsia Angeline Lee , Harish Kumar Mysore Nagaraj , Anders Poulsen , Eric T. Sun , Yee Ling Evelyn Tan , Anthony Deodaunia William
IPC分类号： A61K31/5377 , A61K31/519 , C07D498/08 , A61P35/04 , A61P35/02 , A61P13/10 , A61P21/00 , A61P25/28 , C12N9/99 , A61P35/00
CPC分类号： A61K31/519 , A61K31/5377 , C07D498/06 , C07D498/08 , C07D498/16 , C07D498/18 , C07D515/16 , C07D515/18
摘要： The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to oxygen linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with kinases.
摘要翻译： 本发明涉及可用作抗增殖剂的嘧啶化合物。 更具体地，本发明涉及氧连接和取代的嘧啶化合物，其制备方法，含有这些化合物的药物组合物和这些化合物在治疗增殖性疾病中的用途。 这些化合物可用作治疗许多增殖性疾病（包括肿瘤和癌症）以及与激酶相关或与激酶相关的其它病症或病症的药物。
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![(9E)-15-(2-PYRROLIDIN-1-YL-ETHOXY)-7,12,25-TRIOXA-19,21,24-TRIAZA-TETRACYCLO[18.3.1.1(2.5).1(14,18)]HEXACOSA-1(24),2,4,9,14,16,18(26),20,22-NONAENE CITRATE SALT](/abs-image/US/2012/08/02/US20120196876A1/abs.jpg.150x150.jpg)
9.发明申请(9E)-15-(2-PYRROLIDIN-1-YL-ETHOXY)-7,12,25-TRIOXA-19,21,24-TRIAZA-TETRACYCLO[18.3.1.1(2.5).1(14,18)]HEXACOSA-1(24),2,4,9,14,16,18(26),20,22-NONAENE CITRATE SALT 有权（9E）-15-（2-吡咯烷-1-基 - 乙氧基）-7,12,25-三氧杂环己烷-2,19,21,24-三唑并[4,3-b] [18.3.1.1（2.5）.1（14,18）] HEXACOSA-1（24），2,4,9,14,16,18（26），20,22-NONAENE CITRATE SALT公开(公告)号：US20120196876A1
公开(公告)日：2012-08-02
申请号：US13384139
申请日：2010-07-14
IPC分类号： A61K31/519 , A61P35/00 , C07D498/16
CPC分类号： C07D498/18
摘要： The present invention relates to certain salts of a 9E-15-(2-pyrrolidin-1-yl-ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5). 1(14,18)]hexacosa-1(24),2,4,9, 14,16,18(26),20,22-nonaene (Compound I) which have been found to have improved properties. In particular the present invention relates to the citrate salt of this compound. The invention also relates to pharmaceutical compositions containing the citrate salt and methods of use of the citrate salt in the treatment of certain medical conditions.
摘要翻译： 本发明涉及9E-15-（2-吡咯烷-1-基 - 乙氧基）-7,12,25-三氧杂-9,21,24-三氮杂 - 四环[18.3.1.1（2.5 ）。 已经发现具有改善的性质的1（14,18）]六十一-1（24），2,4,9,14,16,18（26），20,22-非烯（化合物I）。 特别地，本发明涉及该化合物的柠檬酸盐。 本发明还涉及含有柠檬酸盐的药物组合物和柠檬酸盐在使用某些医疗条件下的使用方法。
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