公开(公告)号：US20060068411A1

公开(公告)日：2006-03-30

申请号：US11074129

申请日：2005-03-07

申请人： Stanley Chang ,  Hsun-Lang Chang ,  Wei-Ying Kuo ,  Kuo-Yen Chen ,  Ning-Yi Li ,  Chih-Ping Hsu ,  Pei-Hsun Ho

发明人： Stanley Chang ,  Hsun-Lang Chang ,  Wei-Ying Kuo ,  Kuo-Yen Chen ,  Ning-Yi Li ,  Chih-Ping Hsu ,  Pei-Hsun Ho

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： G01N33/5748 ,  C07K16/30 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158

摘要： MH15 (Hn1L) is identified as an oncogene. Methods and compositions for detecting and diagnosing cancer in patients are provided, by determining the level of MH15 expression in biological samples. Also provided are methods for screening for inhibitors and moderators of MH15 expression and activity, as well as compositions comprising compounds and molecules that inhibit or moderate MH15 expression or activity, thereby treating cancer, in vivo.

公开(公告)号：US07507532B2

公开(公告)日：2009-03-24

申请号：US11074129

申请日：2005-03-07

申请人： Stanley Chang ,  Hsun-Lang Chang ,  Wei-Ying Kuo ,  Kuo-Yen Chen ,  Ning-Yi Li ,  Chih-Ping Hsu ,  Pei-Hsun Ho

发明人： Stanley Chang ,  Hsun-Lang Chang ,  Wei-Ying Kuo ,  Kuo-Yen Chen ,  Ning-Yi Li ,  Chih-Ping Hsu ,  Pei-Hsun Ho

IPC分类号： C12Q1/68

CPC分类号： G01N33/5748 ,  C07K16/30 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158

摘要： MH15 (Hn1L) is identified as an oncogene. Methods and compositions for detecting and diagnosing cancer in patients are provided, by determining the level of MH15 expression in biological samples. Also provided are methods for screening for inhibitors and moderators of MH15 expression and activity, as well as compositions comprising compounds and molecules that inhibit or moderate MH15 expression or activity, thereby treating cancer, in vivo.

摘要翻译： MH15（Hn1L）被鉴定为癌基因。 通过确定生物样品中MH15表达的水平，提供了检测和诊断患者癌症的方法和组合物。 还提供了用于筛选MH15表达和活性的抑制剂和调节剂的方法，以及包含抑制或抑制MH15表达或活性，从而在体内治疗癌症的化合物和分子的组合物。

公开(公告)号：US20050153352A1

公开(公告)日：2005-07-14

申请号：US11031922

申请日：2005-01-07

申请人： Stanley Chang ,  Hsun-Lang Chang ,  Wei-Ying Kuo ,  Kuo-Yen Chen ,  Ning-Yi Li

发明人： Stanley Chang ,  Hsun-Lang Chang ,  Wei-Ying Kuo ,  Kuo-Yen Chen ,  Ning-Yi Li

IPC分类号： C07H21/04 ,  C07K14/47 ,  C07K16/30 ,  C07K16/32 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C07H21/04 ,  C07K16/32 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/178 ,  G01N33/57484

摘要： MG20 (CCNDBP1) is identified as an oncogene. Methods and compositions for detecting and diagnosing cancer in patients are provided, by determining the level of MG20 expression in biological samples. Also provided are methods for screening for inhibitors and moderators of MG20 expression and activity, as well as compositions comprising compounds and molecules that inhibit or moderate MG20 expression or activity, thereby treating cancer, in vivo.

摘要翻译： MG20（CCNDBP1）被鉴定为癌基因。 通过确定生物样品中MG20表达的水平，提供了检测和诊断患者癌症的方法和组合物。 还提供了用于筛选MG20表达和活性的抑制剂和调节剂的方法，以及包含抑制或缓和MG20表达或活性，从而在体内治疗癌症的化合物和分子的组合物。