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    Implantable stimulation and drug infusion techniques
    1.
    发明授权
    Implantable stimulation and drug infusion techniques 失效
    植入式刺激和药物输注技术

    公开(公告)号：US5697951A

    公开(公告)日：1997-12-16

    申请号：US637362

    申请日：1996-04-25

    申请人： Stanley D. Harpstead ,  Lynn M. Otten ,  Thomas R. Prentice

    发明人： Stanley D. Harpstead ,  Lynn M. Otten ,  Thomas R. Prentice

    IPC分类号： A61N1/32 ,  A61N1/40 ,  A61N1/02

    CPC分类号： A61N1/40 ,  A61N1/325 ,  A61N1/306

    摘要： An implantable system for infusing a fluid agent and providing electrical stimulation without requiring an implanted pump or implanted source of electrical energy. An implantable housing is fitted with a percutaneous fill port that communicates with a reservoir to hold a fluid agent, such as a drug. An antenna located inside the housing receives radio frequency power signals from an outside antenna. A pulse generator outside the housing receives power and information from the radio frequency signals to produce stimulation pulses. The pulses and the fluid agent are both transported by a catheter to a site of application in the body. A connector allows the stimulation pulses and fluid agent to be transported from the housing to the catheter while maintaining electrical isolation between the stimulating pulses and the fluid agent.

    摘要翻译： 一种植入式系统，用于输注流体试剂并提供电刺激，而不需要植入的泵或植入的电能源。 植入式壳体配有经皮填充口，其与储存器连通以容纳液体剂，例如药物。 位于壳体内部的天线接收来自外部天线的射频功率信号。 壳体外的脉冲发生器从射频信号接收功率和信息，产生刺激脉冲。 脉冲和流体药物都通过导管输送到体内应用的部位。 连接器允许刺激脉冲和流体试剂从壳体输送到导管，同时保持刺激脉冲和流体试剂之间的电隔离。

    Device having a microporous membrane lined deformable wall for implanting cell cultures
    2.
    发明授权
    Device having a microporous membrane lined deformable wall for implanting cell cultures 失效
    具有用于植入细胞培养物的微孔膜衬里的可变形壁的装置

    公开(公告)号：US06479066B1

    公开(公告)日：2002-11-12

    申请号：US09464560

    申请日：1999-12-16

    申请人： Stanley D. Harpstead

    发明人： Stanley D. Harpstead

    IPC分类号： A61F200

    CPC分类号： A61K9/0024 ,  A61L27/3804

    摘要： A device and method of using the device are provided for implanting cell cultures in a host. The device is formed of a deformable body, a microporous membrane and a sealable port. The shape of the body which is preferably rounded can be altered by applying stress or pressure, The body comprises a continuous wall constructed of a mesh material, and the membrane lines a surface of the body. The wall and membrane define an enclosed three-dimensional cavity for containing a cell culture. Openings of the membrane allow for passage of therapeutic substances produced by the cells and nutrients or biomolecules produced by host. The sealable port is configured for adding a cell culture to the cavity, and is formed of a material that is capable of resealing after being punctured with a needle. Because the device is deformable, it can be compressed and placed in an implantation site where it expands to conform to contours of tissue surrounding the site. The mesh may be formed of spring tempered stainless steal or memory metals. The membrane may be coated with a material such as extracellular matrix material that facilitates attachment of cells such as by ionic or covalent bonding. An external surface of the device may be coated with an angiogenic material.

    摘要翻译： 提供了一种使用该装置的装置和方法，用于将细胞培养物植入宿主体内。 该装置由可变形体，微孔膜和可密封端口形成。 优选为圆形的本体的形状可以通过施加应力或压力来改变。本体包括由网状材料构成的连续壁，并且该膜在该体的表面上划线。 壁和膜限定用于容纳细胞培养物的封闭的三维空腔。 膜的开口允许通过由细胞和营养物质产生的治疗物质或由宿主产生的生物分子。 可密封端口被配置为将细胞培养物添加到空腔中，并且由能够用针刺穿后能够再密封的材料形成。 因为该装置是可变形的，所以可以将其压缩并放置在植入位置，在其中它被扩展以符合围绕该部位的组织轮廓。 网可以由弹簧钢化不锈钢或记忆金属形成。 膜可以涂覆有诸如细胞外基质材料的材料，其促进诸如通过离子或共价结合的细胞附着。 该装置的外表面可以用血管生成材料涂覆。