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公开(公告)号：US07968719B2
公开(公告)日：2011-06-28
申请号：US12431010
申请日：2009-04-28
IPC分类号： C07D487/04 , A61K31/4375
CPC分类号： C07D413/12 , C07D231/56 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to indazole derivatives of the general formulae I or II having the meanings indicated in the description, to the pharmaceutically useful salts thereof and the use thereof as drugs.
摘要翻译： 本发明涉及具有本说明书中所述含义的通式I或II的吲唑衍生物及其药学上可用的盐及其作为药物的用途。
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公开(公告)号：US07528155B2
公开(公告)日：2009-05-05
申请号：US11042565
申请日：2005-01-25
IPC分类号： A61K31/454
CPC分类号： C07D413/12 , C07D231/56 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to indazole derivatives of the general formulae I or II having the meanings indicated in the description, to the pharmaceutically useful salts thereof and the use thereof as drugs.
摘要翻译： 本发明涉及具有本说明书所示含义的通式I或II的吲唑衍生物，其药学上可用的盐及其作为药物的用途。
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公开(公告)号：US20090215824A1
公开(公告)日：2009-08-27
申请号：US12431010
申请日：2009-04-28
IPC分类号： A61K31/454 , C07D401/04
CPC分类号： C07D413/12 , C07D231/56 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to indazole derivatives of the general formulae I or II having the meanings indicated in the description, to the pharmaceutically useful salts thereof and the use thereof as drugs.
摘要翻译： 本发明涉及具有本说明书所示含义的通式I或II的吲唑衍生物，其药学上可用的盐及其作为药物的用途。
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4.发明申请公开(公告)号：US20090030011A1
公开(公告)日：2009-01-29
申请号：US12099922
申请日：2008-04-09
IPC分类号： A61K31/437 , A61P3/00 , C07D471/04 , A61K31/4725 , A61K31/4709 , A61K31/4545 , A61K31/496
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention relates to triazolopyridine derivatives of general formula (I), which are defined as cited in the description, to their pharmaceutically applicable salts and to their use as medicaments.
摘要翻译： 本发明涉及通式（I）的三唑并吡啶衍生物，其定义如本说明书中引用的其药学上可应用的盐及其作为药物的用途。
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公开(公告)号：US20050197348A1
公开(公告)日：2005-09-08
申请号：US11042565
申请日：2005-01-25
IPC分类号： A61K31/416 , C07D231/56 , A61K31/519 , A61K31/454 , A61K31/4745 , C07D471/02 , C07D487/02
CPC分类号： C07D413/12 , C07D231/56 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to indazole derivatives of the general formulae I or II having the meanings indicated in the description, to the pharmaceutically useful salts thereof and the use thereof as drugs.
摘要翻译： 本发明涉及具有本说明书中所述含义的通式I或II的吲唑衍生物及其药学上可用的盐及其作为药物的用途。
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6.发明申请公开(公告)号：US20080161370A1
公开(公告)日：2008-07-03
申请号：US11950948
申请日：2007-12-05
申请人： Gerhard Zoller , Stefan Petry , Gunter Muller , Hubert Heuer , Norbert Tennagels
发明人： Gerhard Zoller , Stefan Petry , Gunter Muller , Hubert Heuer , Norbert Tennagels
IPC分类号： A61K31/428 , C07D277/62 , A61P3/00
CPC分类号： C07D277/68
摘要： The invention relates to benzothiazol-2-one derivatives of general formula (I) with the meanings indicated in the description, the pharmaceutically usable salts thereof, and the use thereof as medicinal substances.
摘要翻译： 本发明涉及通式（I）的苯并噻唑-2-酮衍生物，其具有说明书中所述的含义，其药学上可用的盐及其作为药用物质的用途。
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公开(公告)号：US20080090867A1
公开(公告)日：2008-04-17
申请号：US11873846
申请日：2007-10-17
申请人： Gerhard Zoller , Stefan Petry , Gunter Muller , Hubert Heuer , Norbert Tennagels
发明人： Gerhard Zoller , Stefan Petry , Gunter Muller , Hubert Heuer , Norbert Tennagels
IPC分类号： A61K31/4523 , A61K31/423 , A61P43/00 , C07D275/04 , C07D498/04 , C07D211/00 , A61K31/428
CPC分类号： C07D261/20 , C07D275/04 , C07D413/12 , C07D513/04
摘要： The invention relates to azole derivatives of the general formula I as defined in the present application as well as to their uses in treatment of conditions that would benefit from their inhibitory effect on hormone sensitive lipase, HSL, an allosteric enzyme in adipocytes which is inhibited by insulin and is responsible for the breakdown of fats in fat cells and thus for transferring fat constituents into the blood stream. Inhibition of this enzyme is therefore equivalent to an insulin-like effect of the compounds of the invention.
摘要翻译： 本发明涉及本申请中定义的通式I的唑衍生物，以及它们在治疗受益于其对激素敏感性脂肪酶HSL（对脂肪细胞中受抑制的脂肪细胞中的变构酶）的抑制作用的条件的用途 胰岛素，并且负责脂肪细胞中脂肪的分解，从而将脂肪成分转移到血液中。 因此，该酶的抑制等同于本发明化合物的胰岛素样效应。
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公开(公告)号：US20080287448A1
公开(公告)日：2008-11-20
申请号：US12099337
申请日：2008-04-08
申请人： Gerhard Zoller , Stefan Petry , Gunter Muller , Hubert Heuer , Norbert Tennagels
发明人： Gerhard Zoller , Stefan Petry , Gunter Muller , Hubert Heuer , Norbert Tennagels
IPC分类号： A61K31/519 , C07D487/04 , C07D471/04 , A61K31/437 , A61P3/00 , A61K31/4985 , A61K31/5025
CPC分类号： C07D231/56 , C07D401/14 , C07D471/04 , C07D495/04
摘要： The invention relates to diacyl indazole derivatives of general formulae (I) or (II) and to the pharmaceutically acceptable salts thereof: Wherein X, R1 and R2 are as defined herein. The invention also relates to the use of these compounds as pharmaceutical products.
摘要翻译： 本发明涉及通式（I）或（II）的二酰基吲唑衍生物及其药学上可接受的盐：其中X，R 1和R 2如本文所定义。 本发明还涉及这些化合物作为药物产品的用途。
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公开(公告)号：US08357698B2
公开(公告)日：2013-01-22
申请号：US12839863
申请日：2010-07-20
申请人： Gerhard Zoller , Stefan Petry , Gunter Muller , Hubert Heuer , Norbert Tennagels
发明人： Gerhard Zoller , Stefan Petry , Gunter Muller , Hubert Heuer , Norbert Tennagels
IPC分类号： C07D487/04 , A61K31/4375
CPC分类号： C07D231/56 , C07D401/14 , C07D471/04 , C07D495/04
摘要： The invention relates to diacyl indazole derivatives of general formulae (I) or (II) and to the pharmaceutically acceptable salts thereof: Wherein X, R1 and R2 are as defined herein. The invention also relates to the use of these compounds to treat diabetes mellitus, dyslipidemia and atherosclerotic disorders.
摘要翻译： 本发明涉及通式（I）或（II）的二酰基吲唑衍生物及其药学上可接受的盐：其中X，R 1和R 2如本文所定义。 本发明还涉及这些化合物用于治疗糖尿病，血脂异常和动脉粥样硬化性疾病的用途。
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公开(公告)号：US08921404B2
公开(公告)日：2014-12-30
申请号：US11873846
申请日：2007-10-17
申请人： Gerhard Zoller , Stefan Petry , Gunter Muller , Hubert Heuer , Norbert Tennagels
发明人： Gerhard Zoller , Stefan Petry , Gunter Muller , Hubert Heuer , Norbert Tennagels
IPC分类号： A61K31/4523 , A61K31/423 , A61K31/428 , C07D275/04 , C07D498/04 , C07D261/20 , C07D413/12 , C07D513/04
CPC分类号： C07D261/20 , C07D275/04 , C07D413/12 , C07D513/04
摘要： The invention relates to azole derivatives of the general formula I as defined in the present application as well as to their uses in treatment of conditions that would benefit from their inhibitory effect on hormone sensitive lipase, HSL, an allosteric enzyme in adipocytes which is inhibited by insulin and is responsible for the breakdown of fats in fat cells and thus for transferring fat constituents into the blood stream. Inhibition of this enzyme is therefore equivalent to an insulin-like effect of the compounds of the invention.
摘要翻译： 本发明涉及本申请中定义的通式I的唑衍生物，以及它们在治疗受益于其对激素敏感性脂肪酶HSL（对脂肪细胞中受抑制的脂肪细胞中的变构酶）的抑制作用的条件的用途 胰岛素，并且负责脂肪细胞中脂肪的分解，从而将脂肪成分转移到血液中。 因此，该酶的抑制等同于本发明化合物的胰岛素样效应。
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