公开(公告)号：US20060264414A1

公开(公告)日：2006-11-23

申请号：US11400886

申请日：2006-04-10

申请人： Stephen Carper ,  Byron Bennett

发明人： Stephen Carper ,  Byron Bennett

IPC分类号： A61K31/555 ,  C07F15/00

CPC分类号： C07F15/0093

摘要： A series of 2,2′-bipyridines or 1,10-phenanthrolines featuring alkyl groups appended in the 4,4′ positions or 4,7-positions have been prepared. There is an insulating role of the methylene spacers as the electrochemical reduction potentials of these compounds that is almost identical to that of 2,2′-bipyridine. Calculations for (CH2)nCF3 derivatives (n=0-10) describes a limit for impact of CF3 through 9-10 methylenes. From both physical and theoretical data (CH2)3(CF2)x-1CF3 alkyl groups are inductively equivalent to hydrogen. Complexes of the present invention have the formula cis-LPtCl2 where L is a 4,4′-substituted-2,2′-bipyridine or a 4,7-substituted-1,10-phenanthroline. The substituents may preferably be normal, branched and cyclic alkyl groups, alkyl groups with ether linkages, highly fluorinated alkyl group, highly fluorinated alkyl groups with ether linkages, hydroxyl terminated alkyl groups, hydroxyl-terminated alkyl groups with ether linkages and perfluorinated alkyl groups.

摘要翻译： 已经制备了一系列在4,4'位或4,7-位上附有烷基的2,2'-联吡啶或1,10-菲咯啉。 这些化合物的电化学还原电位与2,2'-联吡啶几乎相同，亚甲基间隔物具有绝缘作用。 （CH 2/2）N 3 CF 3衍生物（n = 0-10）的计算描述了CF 3的衍生物的影响的限制， 通过9-10亚甲基。 从物理和理论数据（CH 2 2）3（CF 2）x-1 CF 2 3个烷基的电感相当于氢。 本发明的配合物具有式为cis-LPtCl 2的化合物，其中L为4,4'-取代-2,2'-联吡啶或4,7-取代-1,10-菲咯啉。 取代基可以优选为正构的，支链的和环状的烷基，具有醚键的烷基，高度氟化的烷基，具有醚键的高度氟化的烷基，羟基封端的烷基，具有醚键的羟基封端的烷基和全氟化的烷基。

公开(公告)号：US08426387B2

公开(公告)日：2013-04-23

申请号：US11731297

申请日：2007-03-30

申请人： Stephen Carper ,  Susan Meacham

发明人： Stephen Carper ,  Susan Meacham

IPC分类号： A61K31/69 ,  A61K33/22

CPC分类号： A61K31/69

摘要： Phenyl boric acid and its salts and substituent derivatives (e.g., substituted phenyl) effectively inhibit the growth of several cancer cell lines and offers utility in the treatment/prevention of cancer. The material may be applied or injected into affected areas or applied topically, especially for the treatment of cervical cancer.

摘要翻译： 苯基硼酸及其盐和取代基衍生物（例如取代的苯基）有效地抑制了几种癌细胞系的生长并提供了治疗/预防癌症的效用。 该材料可以施用或注射到受影响的区域或局部施用，特别是用于治疗子宫颈癌。

公开(公告)号：US20070232569A1

公开(公告)日：2007-10-04

申请号：US11731297

申请日：2007-03-30

申请人： Stephen Carper ,  Susan Meacham

发明人： Stephen Carper ,  Susan Meacham

IPC分类号： A61K31/69

CPC分类号： A61K31/69

摘要： Phenyl boric acid and its salts and substituent derivatives (e.g., substituted phenyl) effectively inhibit the growth of several cancer cell lines and offers utility in the treatment/prevention of cancer. The material may be applied or injected into affected areas or applied topically, especially for the treatment of cervical cancer.

摘要翻译： 苯基硼酸及其盐和取代基衍生物（例如取代的苯基）有效地抑制了几种癌细胞系的生长并提供了治疗/预防癌症的效用。 该材料可以施用或注射到受影响的区域或局部施用，特别是用于治疗子宫颈癌。

公开(公告)号：US20070059382A1

公开(公告)日：2007-03-15

申请号：US11519116

申请日：2006-09-11

申请人： Stephen Carper ,  Susan Meacham

发明人： Stephen Carper ,  Susan Meacham

IPC分类号： A61K33/22

CPC分类号： A61K33/22

摘要： Breast cancer cell lines selected from the group consisting of ZR-75-1 and SK-BR-3 are treated by a method comprising: identifying the presence of at least one of breast cancer cell lines ZR-75-1 and SK-BR-3 in a patient; and providing a solution of boric acid or boric acid salts to the patient in a manner that delivers boric acid or boric acid salt to breast cancer cells in the patient.

摘要翻译： 通过包括以下方法处理选自ZR-75-1和SK-BR-3组的乳腺癌细胞系：鉴定乳腺癌细胞系ZR-75-1和SK-BR- 3在病人身上 并以向患者的乳腺癌细胞递送硼酸或硼酸盐的方式向患者提供硼酸或硼酸盐溶液。