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公开(公告)号：US07470679B2
公开(公告)日：2008-12-30
申请号：US11742615
申请日：2007-05-01
IPC分类号： C07D487/04 , C07D401/14 , C07D519/00 , A61K31/55 , A61P25/06
CPC分类号： C07D491/04 , C07D487/04
摘要： The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
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公开(公告)号：US07384931B2
公开(公告)日：2008-06-10
申请号：US11417326
申请日：2006-05-03
IPC分类号： C07D487/04 , C07D401/14 , C07D519/00 , A61K31/55 , A61P25/06
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors
摘要翻译： 本发明包括受限制的双环和三环CGRP受体拮抗剂，鉴定它们的方法，包含它们的药物组合物及其用于治疗偏头痛和其他头痛，神经源性血管舒张，神经源性炎症，热损伤，循环休克，冲洗的方法 与更年期，气道炎症性疾病如哮喘和慢性阻塞性肺疾病（COPD）有关的其他病症，其治疗可以通过CGRP受体的拮抗作用
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公开(公告)号：US07544680B2
公开(公告)日：2009-06-09
申请号：US12105434
申请日：2008-04-18
IPC分类号： C07D487/00 , C07D491/00 , A61K31/55 , A61P25/06
CPC分类号： C07D487/04
摘要： The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
摘要翻译： 本发明包括受限制的双环和三环CGRP受体拮抗剂，鉴定它们的方法，包含它们的药物组合物及其用于治疗偏头痛和其他头痛，神经源性血管舒张，神经源性炎症，热损伤，循环休克，冲洗的方法 与更年期，气道炎症性疾病如哮喘和慢性阻塞性肺疾病（COPD）相关的其它病症以及其治疗可以通过CGRP受体的拮抗作用来实现。
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公开(公告)号：US20080287422A1
公开(公告)日：2008-11-20
申请号：US12105434
申请日：2008-04-18
IPC分类号： A61K31/55 , C07D487/04 , A61P25/06
CPC分类号： C07D487/04
摘要： The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
摘要翻译： 本发明包括受限制的双环和三环CGRP受体拮抗剂，鉴定它们的方法，包含它们的药物组合物及其用于治疗偏头痛和其他头痛，神经源性血管舒张，神经源性炎症，热损伤，循环休克，冲洗的方法 与更年期，气道炎症性疾病如哮喘和慢性阻塞性肺疾病（COPD）相关的其它病症以及其治疗可以通过CGRP受体的拮抗作用来实现。
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公开(公告)号：US07384930B2
公开(公告)日：2008-06-10
申请号：US11247697
申请日：2005-10-11
IPC分类号： C07D487/04 , C07D401/14 , C07D519/00 , A61P25/06 , A61K31/55
CPC分类号： C07D487/04
摘要： The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
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公开(公告)号：US20070259850A1
公开(公告)日：2007-11-08
申请号：US11742615
申请日：2007-05-01
IPC分类号： A61K31/55 , A61K31/454 , A61K31/4188 , A61K31/4162 , C07D491/02 , C07D487/02
CPC分类号： C07D491/04 , C07D487/04
摘要： The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
摘要翻译： 本发明包括受限制的双环和三环CGRP受体拮抗剂，鉴定它们的方法，包含它们的药物组合物及其用于治疗偏头痛和其他头痛，神经源性血管舒张，神经源性炎症，热损伤，循环休克，冲洗的方法 与更年期，气道炎症性疾病如哮喘和慢性阻塞性肺疾病（COPD）相关的其它病症以及其治疗可以通过CGRP受体的拮抗作用来实现。
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公开(公告)号：US07470680B2
公开(公告)日：2008-12-30
申请号：US11742626
申请日：2007-05-01
申请人： Prasad V. Chaturvedula , Stephen E. Mercer , Haiquan Fang , Xiaojun Han , Guanglin Luo , Gene M. Dubowchik , Graham S. Poindexter
发明人： Prasad V. Chaturvedula , Stephen E. Mercer , Haiquan Fang , Xiaojun Han , Guanglin Luo , Gene M. Dubowchik , Graham S. Poindexter
IPC分类号： C07D487/04 , C07D401/14 , C07D519/00 , A61K31/55 , A61P25/06
CPC分类号： C07D487/04
摘要： The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
摘要翻译： 本发明包括受限制的双环和三环CGRP受体拮抗剂，鉴定它们的方法，包含它们的药物组合物及其用于治疗偏头痛和其他头痛，神经源性血管舒张，神经源性炎症，热损伤，循环休克，冲洗的方法 与更年期，气道炎症性疾病如哮喘和慢性阻塞性肺疾病（COPD）相关的其它病症以及其治疗可以通过CGRP受体的拮抗作用来实现。
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公开(公告)号：US20070259851A1
公开(公告)日：2007-11-08
申请号：US11742626
申请日：2007-05-01
申请人： Prasad V. Chaturvedula , Stephen E. Mercer , Haiquan Fang , Xiaojun Han , Guanglin Luo , Gene M. Dubowchik , Graham S. Poindexter
发明人： Prasad V. Chaturvedula , Stephen E. Mercer , Haiquan Fang , Xiaojun Han , Guanglin Luo , Gene M. Dubowchik , Graham S. Poindexter
IPC分类号： A61K31/55 , C07D471/02 , A61K31/519 , A61K31/517 , A61K31/4747 , A61K31/4745 , A61K31/4709 , C07D487/02
CPC分类号： C07D487/04
摘要： The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
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9.发明授权Isoxazoline derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme 有权异恶唑啉衍生物作为基质金属蛋白酶和/或TNF-α转化酶的抑制剂公开(公告)号：US07125870B2
公开(公告)日：2006-10-24
申请号：US10697545
申请日：2003-10-30
IPC分类号： A01N47/40
CPC分类号： C07D413/14 , C07D413/12
摘要： The present application describes novel isoxazoline of formula I or II: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, R1, R2, R3, R4, Z, U, X, Y, Za, and n are defined in the present specification, which are useful as inhibitors of matrix metalloproteinases (MMP), TNF-α converting enzyme (TACE), or a combination thereof.
摘要翻译： 本申请描述了式I或II的新型异恶唑啉或其药学上可接受的盐或前药形式，其中A，R 1，R 2，R 3， R 4，Z 4，U，X，Y，Z a，以及n在本说明书中定义，其可用作基质金属蛋白酶抑制剂（ MMP），TNF-α转化酶（TACE）或其组合。
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公开(公告)号：US07772244B2
公开(公告)日：2010-08-10
申请号：US11091429
申请日：2005-03-28
IPC分类号： A61K31/517 , A61K31/47 , C07D215/227 , C07D239/80
CPC分类号： C07D401/14
摘要： The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
摘要翻译： 本发明涉及作为降钙素基因相关肽受体（“CGRP受体”）拮抗剂的式（I）化合物，包含它们的药物组合物，鉴定它们的方法，使用它们的治疗方法及其在治疗治疗中的用途 神经源性血管舒张，神经源性炎症，偏头痛和其他头痛，热损伤，循环休克，与更年期相关的潮红，气道炎症性疾病如哮喘和慢性阻塞性肺疾病（COPD）以及其他治疗可以通过 CGRP受体的拮抗作用。
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