公开(公告)号：US20140031246A1

公开(公告)日：2014-01-30

申请号：US13811530

申请日：2011-07-22

申请人： Stephen J. Meltzer ,  Jee-Hoon Song ,  Yulan Cheng

发明人： Stephen J. Meltzer ,  Jee-Hoon Song ,  Yulan Cheng

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/178

摘要： The present invention relates to the field of biomarkers. More specifically, the present invention relates to the use of biomarkers to diagnose and monitor various diseases such as cancer.

摘要翻译： 本发明涉及生物标志物领域。 更具体地，本发明涉及生物标志物用于诊断和监测各种疾病如癌症的用途。

公开(公告)号：US20140031258A1

公开(公告)日：2014-01-30

申请号：US14008057

申请日：2012-03-26

申请人： Stephen J. Meltzer ,  Yulan Cheng ,  Jee-Hoon Song

发明人： Stephen J. Meltzer ,  Yulan Cheng ,  Jee-Hoon Song

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

摘要： Robust and reliable molecular diagnostic screening tools for early detection of esophageal and gastrointestinal tract cancers and pre-cancerous lesions, such as Barrett's Esophagus, and esophageal adenocarcinoma are provided. Included in the invention is an array of miRNA probes specific for identifying, diagnosing and prognosticating esophageal and gastrointestinal tract cancers and pre-cancerous lesions in subjects from blood or serum samples. A biochip comprising the array as well as methods for its use are also provided.

摘要翻译： 提供了用于早期检测食管和胃肠道癌症以及癌前病变（如Barrett食管）和食道腺癌的可靠和可靠的分子诊断筛选工具。 本发明中包括一系列miRNA探针，其特异性用于鉴定，诊断和预测来自血液或血清样品的受试者的食道和胃肠道癌症以及癌前病变。 还提供了包括阵列的生物芯片以及其使用方法。

公开(公告)号：US09758833B2

公开(公告)日：2017-09-12

申请号：US12918438

申请日：2009-02-19

申请人： Stephen J. Meltzer ,  Yulan Cheng ,  Zhe Jin

发明人： Stephen J. Meltzer ,  Yulan Cheng ,  Zhe Jin

IPC分类号： C12P21/06 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/156

摘要： This invention relates, e.g., to methods for predicting a subject's risk for developing esophageal adenocarcinoma (EAC) or high-grade dysplasia (HGD), comprising determining in a sample from the subject the methylation levels of transcriptional promoter regions of various combinations of, among other genes, (a) cadherin 13, H-cadherin (heart) (CDH13); (b) tachykinin-1 (TAC1); (c) nel-like 1 (NELL1); (d) A-kinase anchoring protein 12 (AKAP12); (e) somatostatin (SST); (f) transmembrane protein with EGF-like and two follistatin-like domains (HPP1); (g) CDKN2a, cyclin-dependent kinase inhibitor 2a (p16); or (h) runt-related transcription factor 3 (RUNX3).

公开(公告)号：US20120053066A1

公开(公告)日：2012-03-01

申请号：US12918438

申请日：2009-02-19

申请人： Stephen J. Meltzer ,  Yulan Cheng ,  Zhe Jin

发明人： Stephen J. Meltzer ,  Yulan Cheng ,  Zhe Jin

IPC分类号： C40B30/00 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/156

摘要： This invention relates, e.g., to methods for predicting a subject's risk for developing esophageal adenocarcinoma (EAC) or high-grade dysplasia (HGD), comprising determining in a sample from the subject the methylation levels of transcriptional promoter regions of various combinations of, among other genes, (a) cadherin 13, H-cadherin (heart) (CDH13); (b) tachykinin-1 (TAC1); (c) nel-like 1 (NELL1); (d) A-kinase anchoring protein 12 (AKAP12); (e) somatostatin (SST); (f) transmembrane protein with EGF-like and two follistatin-like domains (HPP1); (g) CDKN2a, cyclin-dependent kinase inhibitor 2a (p16); or (h) runt-related transcription factor 3 (RUNX3).

摘要翻译： 本发明涉及例如用于预测受试者发生食管腺癌（EAC）或高度发育不良（HGD）的风险的方法，其包括在受试者的样品中测定各种组合的转录启动子区域的甲基化水平，其中 其他基因，（a）钙粘蛋白13，H钙粘蛋白（心脏）（CDH13）; （b）速激肽-1（TAC1）; （c）nel样1（NELL1）; （d）α-激酶锚定蛋白12（AKAP12）; （e）生长抑素（SST）; （f）具有EGF样的跨膜蛋白和两个卵泡抑素样结构域（HPP1）; （g）CDKN2a，细胞周期蛋白依赖性激酶抑制剂2a（p16）; 或（h）休克相关转录因子3（RUNX3）。