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1.发明授权Mutated anthrax toxin protective antigen proteins that specifically target cells containing high amounts of cell-surface metalloproteinases or plasminogen activator receptors 失效突变的炭疽毒素保护性抗原蛋白，特异性靶向含有大量细胞表面金属蛋白酶或纤溶酶原激活物受体的细胞公开(公告)号：US08791074B2
公开(公告)日：2014-07-29
申请号：US12288482
申请日：2008-10-20
IPC分类号： A61K38/00
CPC分类号： C07K7/06 , A61K38/00 , A61K47/48353 , A61K47/665 , B82Y5/00 , C07K14/32 , C07K2319/00
摘要： The present invention provides methods of specifically targeting compounds to cells overexpressing matrix metalloproteinases, plasminogen activators, or plasminogen activator receptors, by administering a compound and a mutant protective antigen protein comprising a matrix metalloproteinase or a plasminogen activator-recognized cleavage site in place of the native protective antigen furin-recognized cleavage site, wherein the mutant protective antigen is cleaved by a matrix metalloproteinase or a plasminogen activator overexpressed by the cell, thereby translocating into the cell a compound comprising a lethal factor polypeptide comprising a protective antigen binding site.
摘要翻译： 本发明提供了通过施用化合物和包含基质金属蛋白酶或纤溶酶原激活物识别的切割位点的突变型保护性抗原蛋白代替天然的蛋白质来特异性靶向化合物到过表达基质金属蛋白酶，纤溶酶原激活剂或纤溶酶原激活物受体的细胞的方法 保护性抗原弗林蛋白酶识别的切割位点，其中所述突变保护性抗原由基质金属蛋白酶或由细胞过表达的纤溶酶原激活物切割，从而将含有包含保护性抗原结合位点的致死因子多肽的化合物转位入细胞。
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2.发明申请Mutated anthrax toxin protective antigen proteins that specifically target cells containing high amounts of cell-surface metalloproteinases or plasminogen activator receptors 失效突变的炭疽毒素保护性抗原蛋白，特异性靶向含有大量细胞表面金属蛋白酶或纤溶酶原激活物受体的细胞公开(公告)号：US20090142794A1
公开(公告)日：2009-06-04
申请号：US12288482
申请日：2008-10-20
CPC分类号： C07K7/06 , A61K38/00 , A61K47/48353 , A61K47/665 , B82Y5/00 , C07K14/32 , C07K2319/00
摘要： The present invention provides methods of specifically targeting compounds to cells overexpressing matrix metalloproteinases, plasminogen activators, or plasminogen activator receptors, by administering a compound and a mutant protective antigen protein comprising a matrix metalloproteinase or a plasminogen activator-recognized cleavage site in place of the native protective antigen furin-recognized cleavage site, wherein the mutant protective antigen is cleaved by a matrix metalloproteinase or a plasminogen activator overexpressed by the cell, thereby translocating into the cell a compound comprising a lethal factor polypeptide comprising a protective antigen binding site.
摘要翻译： 本发明提供了通过施用化合物和包含基质金属蛋白酶或纤溶酶原激活物识别的切割位点的突变型保护性抗原蛋白代替天然的蛋白质来特异性靶向化合物到过表达基质金属蛋白酶，纤溶酶原激活剂或纤溶酶原激活物受体的细胞的方法 保护性抗原弗林蛋白酶识别的切割位点，其中所述突变保护性抗原由基质金属蛋白酶或由细胞过表达的纤溶酶原激活物切割，从而将含有包含保护性抗原结合位点的致死因子多肽的化合物转位入细胞。
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3.发明授权Mutated anthrax toxin protective antigen proteins that specifically target cells containing high amounts of cell-surface metalloproteinases or plasminogen activator receptors 有权突变的炭疽毒素保护性抗原蛋白，特异性靶向含有大量细胞表面金属蛋白酶或纤溶酶原激活物受体的细胞公开(公告)号：US07468352B1
公开(公告)日：2008-12-23
申请号：US10088952
申请日：2000-09-22
IPC分类号： A61K38/00
CPC分类号： C07K7/06 , A61K38/00 , A61K47/48353 , A61K47/665 , B82Y5/00 , C07K14/32 , C07K2319/00
摘要： The present invention provides methods of specifically targeting compounds to cells overexpressing matrix metalloproteinases, plasminogen activators, or plasminogen activator receptors, by administering a compound and a mutant protective antigen protein comprising a matrix metalloproteinase or a plasminogen activator-recognized cleavage site in place of the native protective antigen furin-recognized cleavage site, wherein the mutant protective antigen is cleaved by a matrix metalloproteinase or a plasminogen activator overexpressed by the cell, thereby translocating into the cell a compound comprising a lethal factor polypeptide comprising a protective antigen binding site.
摘要翻译： 本发明提供了通过施用化合物和包含基质金属蛋白酶或纤溶酶原激活物识别的切割位点的突变型保护性抗原蛋白代替天然的蛋白质来特异性靶向化合物到过表达基质金属蛋白酶，纤溶酶原激活剂或纤溶酶原激活物受体的细胞的方法 保护性抗原弗林蛋白酶识别的切割位点，其中所述突变保护性抗原由基质金属蛋白酶或由细胞过表达的纤溶酶原激活物切割，从而将含有包含保护性抗原结合位点的致死因子多肽的化合物转位入细胞。
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