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1.发明申请Pharmaceutical Formation For Increased Epithelial Permeability of Glucose-Regulating Peptide 审中-公开药物形成用于增加葡萄糖调节肽的上皮通透性公开(公告)号：US20080318837A1
公开(公告)日：2008-12-25
申请号：US12095801
申请日：2006-12-01
申请人： Steven C. Quay , Henry R. Costantino , Michael V. Templin , Alexis Kays Leonard , Mary S. Kleppe , Joshua O. Sestak
发明人： Steven C. Quay , Henry R. Costantino , Michael V. Templin , Alexis Kays Leonard , Mary S. Kleppe , Joshua O. Sestak
IPC分类号： A61K38/00
摘要： What is described is a pharmaceutical formulation comprising a mixture of a pharmaceutically effective amount of glucose-regulating peptide (GRP) and enhancers, wherein the pharmaceutical formulation is used in the treatment of a metabolic syndrome.
摘要翻译： 描述的是包含药学有效量的葡萄糖调节肽（GRP）和增强剂的混合物的药物制剂，其中药物制剂用于治疗代谢综合征。
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公开(公告)号：US20100311655A1
公开(公告)日：2010-12-09
申请号：US12599267
申请日：2007-09-28
申请人： Alexis Kays Leonard , Joshua O. Sestak , Henry R. Costantino , Anthony P. Sileno , Lalit Raj Peddakota , Kayvon Emile Sharghi , Garland M. Bellamy , Jason Philip Gesty
发明人： Alexis Kays Leonard , Joshua O. Sestak , Henry R. Costantino , Anthony P. Sileno , Lalit Raj Peddakota , Kayvon Emile Sharghi , Garland M. Bellamy , Jason Philip Gesty
CPC分类号： A61K9/0043 , A61K38/095
摘要： Methods and compositions containing oxytocin or an oxytocin analog, such as carbetocin, are provided for the prevention and treatment of autism spectrum disorders, related disorders and symptoms of such disorders. The methods and compositions of this disclosure are effective in the treatment of social withdrawal, eye contact avoidance, repetitive behaviors, anxiety, attention deficit, hyperactivity, depression, loss of speech, verbal communication difficulties, aversion to touch, visual difficulties, comprehension difficulties, and sound and light sensitivity. Additional compositions and methods are provided which employ oxytocin or an oxytocin analog in combination with a secondary or adjunctive therapeutic agent to yield more effective treatment tools against autism spectrum disorders and related disorders.
摘要翻译： 提供含有催产素或催产素类似物（例如卡贝缩略）的方法和组合物用于预防和治疗自闭症谱系障碍，相关疾病和此类病症的症状。 本公开的方法和组成有效地用于治疗社会戒断，避免眼睛接触，重复行为，焦虑，注意力缺陷，多动，抑郁，言语失调，口头沟通困难，厌恶触觉，视力困难，理解困难， 声光灵敏度。 提供了额外的组合物和方法，其使用催产素或催产素类似物与次要或辅助治疗剂组合以产生针对孤独症谱系障碍和相关病症的更有效的治疗工具。
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3.发明申请公开(公告)号：US20080234200A1
公开(公告)日：2008-09-25
申请号：US12124050
申请日：2008-05-20
CPC分类号： A61K9/0043 , A61K9/0056 , A61K9/0073 , A61K9/2086 , A61K38/00 , A61K47/10 , A61K47/18 , A61K47/24
摘要： Methods for treating metabolic diseases are described for intranasal delivery of an exenatide, comprising an aqueous mixture of exendin, and a delivery enhancer selected from the group consisting of a solubilizer, a chelator, and a surfactant, and the pharmaceutical formulations used therein.
摘要翻译： 描述了用于治疗代谢性疾病的方法用于鼻内递送艾塞那肽，其包含毒蜥外泌肽的水性混合物和选自增溶剂，螯合剂和表面活性剂的递送增强剂及其中使用的药物制剂。
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4.发明授权公开(公告)号：US09023793B2
公开(公告)日：2015-05-05
申请号：US13204485
申请日：2011-08-05
申请人： Alexis Kays Leonard , Joshua Orion Sestak , Henry R. Costantino , Anthony P. Sileno , Lalit Raj Peddakota , Kayvon Emile Sharghi , Garland M. Bellamy , Jason Philip Gesty , Steven C. Quay
发明人： Alexis Kays Leonard , Joshua Orion Sestak , Henry R. Costantino , Anthony P. Sileno , Lalit Raj Peddakota , Kayvon Emile Sharghi , Garland M. Bellamy , Jason Philip Gesty , Steven C. Quay
CPC分类号： A61K9/0043 , A61K9/08 , A61K31/337 , A61K45/06 , A61K2300/00
摘要： Methods and compositions containing oxytocin or an oxytocin analog, such as carbetocin, are provided for the prevention and treatment of autism spectrum disorders, related disorders and symptoms of such disorders. The methods and compositions of this disclosure are effective in the treatment of social withdrawal, eye contact avoidance, repetitive behaviors, anxiety, attention deficit, hyperactivity, depression, loss of speech, verbal communication difficulties, aversion to touch, visual difficulties, comprehension difficulties, and sound and light sensitivity. Additional compositions and methods are provided which employ oxytocin or an oxytocin analog in combination with a secondary or adjunctive therapeutic agent to yield more effective treatment tools against autism spectrum disorders and related disorders.
摘要翻译： 提供含有催产素或催产素类似物（例如卡贝缩略）的方法和组合物用于预防和治疗自闭症谱系障碍，相关疾病和此类病症的症状。 本公开的方法和组成有效地用于治疗社会戒断，避免眼睛接触，重复行为，焦虑，注意力缺陷，多动，抑郁，言语失调，口头沟通困难，厌恶触觉，视力困难，理解困难， 声光灵敏度。 提供了额外的组合物和方法，其使用催产素或催产素类似物与次要或辅助治疗剂组合以产生针对孤独症谱系障碍和相关病症的更有效的治疗工具。
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公开(公告)号：US20080318861A1
公开(公告)日：2008-12-25
申请号：US12096650
申请日：2006-12-07
CPC分类号： A61K9/0043 , A61K9/006 , A61K38/2278 , A61K47/40
摘要： What is described is a pharmaceutical formulation for intranasal administration of exendin to a mammal, wherein the formulation comprises a therapeutically effective amount of an exendin, a viscosity enhancer, methyl-β-cyclodextrin, a surfactant, tartrate buffer to control pH and a chelating agent for cations, and wherein such exendin dosage form exhibits at least 95% exenatide recovery after storage for at least 365 days at 5° C.
摘要翻译： 描述了用于鼻内给予哺乳动物毒蜥外泌肽的药物制剂，其中所述制剂包含治疗有效量的毒蜥外泌肽，粘度增强剂，甲基-β-环糊精，表面活性剂，控制pH的酒石酸盐缓冲剂和螯合剂 对于阳离子，并且其中这种毒蜥外泌肽剂型在5℃下储存至少365天后显示出至少95％的艾塞那肽恢复。
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