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    Assessment of CTLA-4 polymorphisms in CTLA-4 blockade therapy
    5.
    发明申请
    Assessment of CTLA-4 polymorphisms in CTLA-4 blockade therapy 审中-公开
    CTLA-4阻断治疗CTLA-4多态性的评估

    公开(公告)号：US20060057626A1

    公开(公告)日：2006-03-16

    申请号：US11218284

    申请日：2005-08-31

    申请人： Geoffrey Nichol ,  Michael Yellin ,  Steven Fischkoff ,  Jeffrey Weber

    发明人： Geoffrey Nichol ,  Michael Yellin ,  Steven Fischkoff ,  Jeffrey Weber

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/142 ,  C12Q2600/156

    摘要： The invention provides methods for predicting responsiveness of a subject to therapy with a CTLA-4 blocking agent. The methods involve assaying for at least one CTLA-4 polymorphism in the subject and predicting responsiveness of the subject to therapy with a CTLA-4 blocking agent based on presence or absence of a CTLA-4 polymorphic allele in the subject. The methods can further comprise selecting a treatment regimen with a CTLA-4 blocking agent in a subject based upon presence or absence of a CTLA-4 polymorphic allele in the subject. The methods can further comprise administering a CTLA-4 blocking agent to the subject according to the selected treatment regimen. Kits comprising a CTLA-4 blocking agent and means for assaying one or more CTLA-4 polymorphisms, optionally including a vaccine, are also provided.

    摘要翻译： 本发明提供了用CTLA-4阻断剂预测受试者对治疗的反应性的方法。 所述方法包括测定受试者中至少一种CTLA-4多态性，并且基于受试者中CTLA-4多态性等位基因的存在或不存在，预测受试者与CTLA-4封闭剂治疗的反应性。 所述方法还可包括基于受试者中CTLA-4多态性等位基因的存在或不存在，在受试者中选择与CTLA-4封闭剂的治疗方案。 所述方法还可以包括根据所选择的治疗方案向受试者施用CTLA-4封闭剂。 还提供了包含CTLA-4封闭剂的试剂盒和用于测定一种或多种CTLA-4多态性（任选地包括疫苗）的方法。