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    Control release of fat soluble antioxidants from an oral formulation and method
    3.
    发明授权
    Control release of fat soluble antioxidants from an oral formulation and method 有权

    公开(公告)号：US10213453B2

    公开(公告)日：2019-02-26

    申请号：US15804469

    申请日：2017-11-06

    申请人： Steven Loyd ,  George Blouin ,  Newsha Farahani ,  Robert Burns

    发明人： Steven Loyd ,  George Blouin ,  Newsha Farahani ,  Robert Burns

    IPC分类号： A61K31/7048 ,  A61K9/00 ,  A61K9/50 ,  A61K31/353 ,  A61K45/06

    摘要： Oral formulation of particles made of an agglomeration of a plurality of seed granules or a single seed granule both surrounded by three layers and an outer gel coating. The seed granules are made of calcium carbonate with microscopic fissures. Disposed inside the fissures and in the interstitial spaces of the agglomerate seed granules are microscopic particles of alkali metal salts and other ions. Coating the agglomerate or single seed granules is an alkaline-resistant first layer made of microcrystalline cellulose and croscarmellose sodium that binds and protects the surrounding second layer. Surrounding the first layer is a second layer comprising a mixture of a flavonoid and polysaccharide or polypeptide binder or polymer gel. Surrounding the second layer is a third layer made of alkaline earth metal salt particles holding alkali metal hydroxide ions within a polysaccharide or polymer gel. Surrounding the third layer is at least one outer gel layer. The fourth and third layers dissolve in a low pH environment and release the fat soluble antioxidant and ions in the seed granule fissures.

    CONTROL RELEASE OF FAT SOLUABLE ANTIOXIDANTS FROM AN ORAL FORMULATION AND METHOD
    4.
    发明申请
    CONTROL RELEASE OF FAT SOLUABLE ANTIOXIDANTS FROM AN ORAL FORMULATION AND METHOD 审中-公开
    从口服制剂和方法控制脂溶性抗氧化剂的释放

    公开(公告)号：US20170020908A1

    公开(公告)日：2017-01-26

    申请号：US15131888

    申请日：2016-04-18

    申请人： Steven Loyd ,  George Blouin ,  Newsha Farahani ,  Robert Burns

    发明人： Steven Loyd ,  George Blouin ,  Newsha Farahani ,  Robert Burns

    IPC分类号： A61K31/7048 ,  A61K9/50 ,  A61K31/353 ,  A61K9/00

    CPC分类号： A61K31/7048 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/501 ,  A61K9/5047 ,  A61K9/5078 ,  A61K9/5089 ,  A61K31/353 ,  A61K45/06

    摘要： Oral formulation of particles made of an agglomeration of a plurality of seed granules or a single seed granule both surrounded by three layers and an outer gel coating. The seed granules are made of calcium carbonate with microscopic fissures. Disposed inside the fissures and in the interstitial spaces of the agglomerate seed granules are microscopic particles of alkali metal salts and other ions. Coating the agglomerate or single seed granules is an alkaline-resistant first layer made of microcrystalline cellulose and croscarmellose sodium that binds and protects the surrounding second layer. Surrounding the second layer is a third layer made of alkaline earth metal salt particles holding alkali metal hydroxide ions within a polysaccharide or polymer gel. Surrounding the third layer is at least one outer gel layer. The fourth and third layers dissolve in a low pH environment and release the fat soluble antioxidant and ions in the seed granule fissures.

    摘要翻译： 由多个种子颗粒或由三层包围的单个种子颗粒的团聚制成的颗粒的口服制剂和外部凝胶涂层。 种子颗粒由具有微观裂缝的碳酸钙制成。 在裂隙内和附聚种子颗粒的间隙中设置有碱金属盐和其它离子的微观颗粒。 附聚物或单一种子颗粒的涂覆是由微晶纤维素和交联羧甲基纤维素钠制成的耐碱性第一层，其结合并保护周围的第二层。 围绕第二层的是在多糖或聚合物凝胶内含有碱金属氢氧根离子的碱土金属盐颗粒制成的第三层。 围绕第三层是至少一个外部凝胶层。 第四和第三层溶解在低pH环境中，释放种子颗粒裂隙中的脂溶性抗氧化剂和离子。