公开(公告)号：US5185142A

公开(公告)日：1993-02-09

申请号：US386095

申请日：1989-07-28

申请人： Steven M. Larson ,  Ronald Finn ,  Jorge A. Carrasquillo ,  James C. Reynolds ,  Ronald D. Neumann ,  Martin C. Graham ,  Keith S. Pentlow

发明人： Steven M. Larson ,  Ronald Finn ,  Jorge A. Carrasquillo ,  James C. Reynolds ,  Ronald D. Neumann ,  Martin C. Graham ,  Keith S. Pentlow

IPC分类号： A61K51/10 ,  C07K16/30

CPC分类号： A61K51/1066 ,  A61K51/1045 ,  C07K16/30 ,  C07K16/3053 ,  A61K2121/00 ,  A61K2123/00

摘要： A composition comprises an antigen-specific antibody or antigen-binding fragment thereof labeled with Iodine-124 at a site other than, and which does not significantly interfere with, the antibody-antigen binding site. An in vivo method of radiotherapy directed to an antigenic site comprises administering to a subject in need of the therapy an amount of the antigen-specific composition described above effective to attain a reduction of the size of a tumor associated with the antigen. An in vivo method for detecting and localizing an antigenic site in a subject in need of such detection comprises administering to the subject an amount of the antigen-specific composition of the invention effective to localize the antigen-antibody binding site and scanning the subject's body with a positron-emitter detector to attain the localization of the site. An in situ method of radiotherapy directed to an antigenic site in a subject in need of such therapy comprises detecting and localizing the site by the in vivo method described above and thereafter in situ delivering a positron-emitting labeled antibody chelate capable of binding to either the I-124 labeled antibody or fragment thereof, or to the antigen at a site other than the antibody-antigen binding site.

摘要翻译： 组合物包含抗原特异性抗体或其抗原结合片段，其在除了抗体 - 抗原结合位点之外的位置处并且不显着干扰抗体 - 抗原结合位点。 针对抗原位点的放射疗法的体内方法包括向需要治疗的受试者施用一定量的上述抗原特异性组合物，以有效降低与抗原相关的肿瘤的大小。 用于检测和定位需要这种检测的受试者中的抗原位点的体内方法包括给予受试者一定量的本发明的抗原特异性组合物有效地定位抗原 - 抗体结合位点并用 一个正电子发射器检测器，以实现该位点的定位。 针对需要这种治疗的受试者中的抗原位点的放射治疗的原位方法包括通过上述体内方法检测和定位该位点，此后原位递送能够结合至 I-124标记的抗体或其片段，或在抗体 - 抗原结合位点以外的位点处的抗原。