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    Endometriosis mouse model
    3.
    发明授权
    Endometriosis mouse model 失效
    子宫内膜异位症小鼠模型

    公开(公告)号：US06429353B1

    公开(公告)日：2002-08-06

    申请号：US09047910

    申请日：1998-03-25

    申请人： Jeffrey Boyd ,  Jerome J. Strauss ,  Peter Van Deerlin ,  Karen K. Yamamoto

    发明人： Jeffrey Boyd ,  Jerome J. Strauss ,  Peter Van Deerlin ,  Karen K. Yamamoto

    IPC分类号： A01K6700

    CPC分类号： C12N15/8509 ,  A01K67/0271 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03

    摘要： The invention provides an endometriosis mouse model wherein severely compromised immune deficient (SCID) female mice are transplanted with human xenografts of normal endometrial tissue, but result in mice with human endometriosis. Typically, the xenografts are treated with a micronized estrogen source prior to transplantation or implantation and the endogenous progesterone of the mice is eliminated also prior to transplantation of the human xenograft. These diseased mice are useful in the study of endometriosis.

    摘要翻译： 本发明提供了一种子宫内膜异位症小鼠模型，其中将严重受损的免疫缺陷（SCID）雌性小鼠移植到正常子宫内膜组织的人异种移植物中，但导致具有人子宫内膜异位症的小鼠。 通常，异种移植物在移植或植入之前用微粉化的雌激素源处理，并且在移植人异种移植物之前也消除了小鼠的内源性孕酮。 这些患病小鼠可用于子宫内膜异位症的研究。

    Table substitution
    4.
    发明授权
    Table substitution 有权

    公开(公告)号：US09600545B2

    公开(公告)日：2017-03-21

    申请号：US11838590

    申请日：2007-08-14

    申请人： Alex Pryce ,  Jeffrey Boyd ,  Scott Kurinskas

    发明人： Alex Pryce ,  Jeffrey Boyd ,  Scott Kurinskas

    IPC分类号： G06F7/00 ,  G06F17/30

    CPC分类号： G06F17/30557 ,  G06F17/303 ,  Y10S707/99942 ,  Y10S707/99943

    摘要： A method and system that enables data to be shared across application systems via a table substitution scheme. Tables are identified in the legacy application system that are candidates for substitution of tables in the core application system containing similar data. Table structure meta data corresponding to these “substituted” tables are then extracted from the legacy system schema, and stored in a repository. In accordance with the meta data, business logic is defined to remap columns in the core tables to corresponding columns in the substituted tables. Accordingly, when the core application system performs data access (e.g., reads, inserts, updates, etc.), it accesses the remapped columns in the substituted tables instead of original columns in the core tables. At the same time, the legacy application system is enabled to concurrently access the substituted tables without require any changes to the business logic of the legacy application system.

    Table Substitution
    5.
    发明申请
    Table Substitution 审中-公开
    表替换

    公开(公告)号：US20070276861A1

    公开(公告)日：2007-11-29

    申请号：US11838590

    申请日：2007-08-14

    申请人： Alex Pryce ,  Jeffrey Boyd ,  Scott Kurinskas

    发明人： Alex Pryce ,  Jeffrey Boyd ,  Scott Kurinskas

    IPC分类号： G06F17/00

    CPC分类号： G06F17/30557 ,  G06F17/303 ,  Y10S707/99942 ,  Y10S707/99943

    摘要： A method and system that enables data to be shared across application systems via a table substitution scheme. Tables are identified in the legacy application system that are candidates for substitution of tables in the core application system containing similar data. Table structure meta data corresponding to these “substituted” tables are then extracted from the legacy system schema, and stored in a repository. In accordance with the meta data, business logic is defined to remap columns in the core tables to corresponding columns in the substituted tables. Accordingly, when the core application system performs data access (e.g., reads, inserts, updates, etc.), it accesses the remapped columns in the substituted tables instead of original columns in the core tables. At the same time, the legacy application system is enabled to concurrently access the substituted tables without require any changes to the business logic of the legacy application system.

    摘要翻译： 一种使数据可以通过表替换方案在应用系统间共享的方法和系统。 在遗留应用系统中标识表，其中包含用于替换包含相似数据的核心应用系统中的表的候选。 然后从遗留系统模式中提取与这些“替换”表对应的表结构元数据，并将其存储在存储库中。 根据元数据，业务逻辑被定义为将核心表中的列重新映射到替换表中的相应列。 因此，当核心应用系统执行数据访问（例如，读取，插入，更新等）时，它访问替换表中的重新映射的列，而不是核心表中的原始列。 同时，传统应用系统能够同时访问替代表，而不需要对传统应用系统的业务逻辑进行任何更改。

    Table substitution
    6.
    发明授权
    Table substitution 有权
    表替换

    公开(公告)号：US07257597B1

    公开(公告)日：2007-08-14

    申请号：US10234417

    申请日：2002-09-03

    申请人： Alex Pryce ,  Jeffrey Boyd ,  Scott Kurinskas

    发明人： Alex Pryce ,  Jeffrey Boyd ,  Scott Kurinskas

    IPC分类号： G06F17/00 ,  G06F7/00

    CPC分类号： G06F17/30557 ,  G06F17/303 ,  Y10S707/99942 ,  Y10S707/99943

    摘要： A method and system that enables data to be shared across application systems via a table substitution scheme. Tables are identified in the legacy application system that are candidates for substitution of tables in the core application system containing similar data. Table structure meta data corresponding to these “substituted” tables are then extracted from the legacy system schema, and stored in a repository. In accordance with the meta data, business logic is defined to remap columns in the core tables to corresponding columns in the substituted tables. Accordingly, when the core application system performs data access (e.g., reads, inserts, updates, etc.), it accesses the remapped columns in the substituted tables instead of original columns in the core tables. At the same time, the legacy application system is enabled to concurrently access the substituted tables without require any changes to the business logic of the legacy application system.

    摘要翻译： 一种使数据可以通过表替换方案在应用系统间共享的方法和系统。 在遗留应用系统中标识表，其中包含用于替换包含相似数据的核心应用系统中的表的候选。 然后从遗留系统模式中提取与这些“替换”表对应的表结构元数据，并将其存储在存储库中。 根据元数据，业务逻辑被定义为将核心表中的列重新映射到替换表中的相应列。 因此，当核心应用系统执行数据访问（例如，读取，插入，更新等）时，它访问替换表中的重新映射的列，而不是核心表中的原始列。 同时，传统应用系统能够同时访问替代表，而不需要对传统应用系统的业务逻辑进行任何更改。

    Identification of ovarian cancer tumor markers and therapeutic targets
    7.
    发明申请
    Identification of ovarian cancer tumor markers and therapeutic targets 审中-公开
    鉴定卵巢癌肿瘤标志物和治疗靶点

    公开(公告)号：US20050095592A1

    公开(公告)日：2005-05-05

    申请号：US10505680

    申请日：2003-02-13

    申请人： Amir Jazaeri ,  Jeffrey Boyd ,  Edison Liu

    发明人： Amir Jazaeri ,  Jeffrey Boyd ,  Edison Liu

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158

    摘要： The present disclosure provides methods for classifying ovarian tumors into BRCA1-type, BRCA2-type or non-BRCA-type tumor types by measuring expression levels of a plurality of disclosed ovarian tumor markers. The markers disclosed herein are useful in the diagnosis, staging, detection, and/or treatment of ovarian cancer. Also provided are methods of selecting a treatment regimen by selecting the tumor type. Ovarian cancer-linked logarithmic expression ratios and kits for diagnosis, staging, and detection of ovarian cancer using are also provided.

    摘要翻译： 本公开提供通过测量多个公开的卵巢肿瘤标志物的表达水平将卵巢肿瘤分类为BRCA1型，BRCA2型或非BRCA型肿瘤类型的方法。 本文公开的标记可用于卵巢癌的诊断，分期，检测和/或治疗。 还提供了通过选择肿瘤类型来选择治疗方案的方法。 还提供了卵巢癌相关对数表达比例和用于诊断，分期和检测卵巢癌的试剂盒。