公开(公告)号：US20230365589A1

公开(公告)日：2023-11-16

申请号：US18026187

申请日：2021-09-17

申请人： Sumitomo Pharma Co., Ltd. ,  CARNA BIOSCIENCES, INC.

发明人： Shingo TOJO ,  Daisuke URABE ,  Hitoshi WATANABE ,  Wataru KAWAHATA ,  Hideki MORIYAMA ,  Yuko ASAMITSU

IPC分类号： C07D519/00

CPC分类号： C07D519/00

摘要： The present invention provides an amine derivative having a DYRK-inhibiting activity and represented by formula (1):




wherein A1, A2, L1, L2, X, Z, R1 and R4 are as defined in the description,

or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230138851A1

公开(公告)日：2023-05-04

申请号：US17795728

申请日：2021-01-28

申请人： CARNA BIOSCIENCES, INC.

发明人： Ayako SAWA ,  Wataru KAWAHATA ,  Yuko ASAMITSU ,  Masaaki SAWA ,  Yasuhiro IWATA ,  Hideki MORIYAMA ,  Shingo TOJO ,  Daisuke URABE

IPC分类号： A61K31/429 ,  C07D513/04 ,  A61K31/437 ,  A61K31/5365

摘要： The present invention provides a compound that has an inhibitory effect on DYRK and that is represented by general formula (I): wherein Q, R1, R2 and R3 are as defined in the description.