公开(公告)号：US20230287009A1

公开(公告)日：2023-09-14

申请号：US18309641

申请日：2023-04-28

申请人： Sumitomo Pharma Co., Ltd. ,  THE KITASATO INSTITUTE

发明人： Toshio KANAI ,  Sachiko KOIKE ,  Takayuki FUKAYA ,  Shunichiro UESUGI ,  Shingo MIZUSHIMA ,  Hitoshi SUDA ,  Yuki MIZUKAMI ,  Yohei IKUMA ,  Toshiaki SUNAZUKA ,  Yoshihiko NOGUCHI

IPC分类号： C07F5/02 ,  A61K45/06 ,  A61P31/04 ,  A61K31/407 ,  A61K31/69

CPC分类号： C07F5/025 ,  A61K45/06 ,  A61P31/04 ,  A61K31/407 ,  A61K31/69

摘要： Provided is a novel compound that has an excellent β-lactamase inhibitory effect. More specifically, provided is a compound represented by formula (1a), (1b) or (11) having an excellent β-lactamase inhibitory effect or a pharmaceutically acceptable salt thereof. By using this compound either in combination with a β-lactam drug or alone, a useful preventive or therapeutic agent for bacterial infections is provided. Also provided are useful preventive or therapeutic agents for treating various diseases with the combined use of the aforesaid compound and β-lactam drugs.

公开(公告)号：US20210147448A1

公开(公告)日：2021-05-20

申请号：US17050747

申请日：2019-04-26

申请人： SUMITOMO DAINIPPON PHARMA CO., LTD. ,  THE KITASATO INSTITUTE

发明人： Toshio KANAI ,  Sachiko KOIKE ,  Takayuki FUKAYA ,  Shunichiro UESUGI ,  Shingo MIZUSHIMA ,  Hitoshi SUDA ,  Yuki MIZUKAMI ,  Yohei IKUMA ,  Toshiaki SUNAZUKA ,  Yoshihiko NOGUCHI

IPC分类号： C07F5/02 ,  A61K45/06

摘要： Provided is a novel compound that has an excellent β-lactamase inhibitory effect. More specifically, provided is a compound represented by formula (1a), (1b) or (11) having an excellent β-lactamase inhibitory effect or a pharmaceutically acceptable salt thereof. By using this compound either in combination with a β-lactam drug or alone, a useful preventive or therapeutic agent for bacterial infections is provided. Also provided are useful preventive or therapeutic agents for treating various diseases with the combined use of the aforesaid compound and β-lactam drugs.

公开(公告)号：US20230038124A1

公开(公告)日：2023-02-09

申请号：US17771241

申请日：2020-10-23

申请人： Sumitomo Pharma Co., Ltd.

发明人： Sachiko KOIKE ,  Yohei IKUMA ,  Takayuki FUKAYA ,  Shunichiro UESUGI

IPC分类号： C07F5/02

摘要： The present invention provides a novel compound having an excellent β-lactamase inhibitory effect. The present invention provides: a compound which has an excellent β-lactamase inhibitory effect, and is represented by formula (1a), (1b) or (11); or a pharmaceutically acceptable salt thereof. This compound provides a prophylactic or therapeutic agent effective for bacterial infections when used in combination with β-lactam-based drugs or used as a single agent. The present invention also provides a prophylactic or therapeutic agent effective for treating various diseases, by being used in combination with β-lactam-based drugs.

公开(公告)号：US20230210850A1

公开(公告)日：2023-07-06

申请号：US18120519

申请日：2023-03-13

申请人： Sumitomo Pharma Co., Ltd.

发明人： Yohei IKUMA ,  Kengo TOJO ,  Ryo FUKAZAWA ,  Shuji MASUMOTO

IPC分类号： A61K31/4985 ,  A61P25/28 ,  C07D519/00

CPC分类号： A61K31/4985 ,  A61P25/28 ,  C07D519/00

摘要： A process for preparing a compound of Formula (1a):




or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230008875A1

公开(公告)日：2023-01-12

申请号：US17889775

申请日：2022-08-17

申请人： Sumitomo Pharma Co., Ltd.

发明人： Hidefumi YOSHINAGA ,  Yohei IKUMA ,  Junya IKEDA ,  Satoshi ADACHI ,  Harunobu MITSUNUMA ,  Yoshinori AIHARA ,  Jeremy BESNARD ,  Andrew Simon BELL

IPC分类号： C07D487/04 ,  C07D471/04

摘要： The present invention relates to a medicament for treating neuropsychiatric diseases, comprising a compound of Formula (1): or a pharmaceutically acceptable salt thereof, as an active ingredient.