公开(公告)号：US20190382474A1

公开(公告)日：2019-12-19

申请号：US16362457

申请日：2019-03-22

申请人： Surface Oncology, Inc. ,  Adimab LLC

发明人： Jonathan HILL ,  Scott CHAPPEL ,  Michael GLADSTONE ,  Bianka PRINZ ,  Andrew LAKE ,  Christine MILLER ,  Kerry WHITE ,  Jing HUA ,  Pamela M. HOLLAND ,  Matthew RAUSCH ,  Devapregasan MOODLEY

IPC分类号： C07K16/24 ,  A61K45/06 ,  A61K39/395 ,  G01N33/68 ,  A61P35/00

摘要： The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the antibodies or antigen-binding portion thereof. The disclosure also relates to methods for detecting IL-27 in, for example, a subject or a sample.

公开(公告)号：US20230042258A1

公开(公告)日：2023-02-09

申请号：US17714942

申请日：2022-04-06

申请人： Surface Oncology, Inc. ,  Adimab LLC

发明人： Jonathan HILL ,  Scott CHAPPEL ,  Michael GLADSTONE ,  Bianka PRINZ ,  Andrew LAKE ,  Christine MILLER ,  Kerry WHITE ,  Jing HUA ,  Pamela M. HOLLAND ,  Matthew RAUSCH ,  Devapregasan MOODLEY

IPC分类号： C07K16/24 ,  A61P35/00 ,  A61K39/395 ,  A61K45/06 ,  G01N33/68

摘要： The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the antibodies or antigen-binding portion thereof. The disclosure also relates to methods for detecting IL-27 in, for example, a subject or a sample.

公开(公告)号：US20220259299A1

公开(公告)日：2022-08-18

申请号：US17413269

申请日：2019-09-25

申请人： SURFACE ONCOLOGY, INC.

发明人： Jonathan HILL ,  Scott CHAPPEL ,  Michael GLADSTONE ,  Bianka PRINZ ,  Andrew LAKE ,  Christine MILLER ,  Kerry WHITE ,  Jing HUA ,  Pamela M. HOLLAND ,  Matthew RAUSCH ,  Devapregasan MOODLEY ,  Gege TAN

IPC分类号： C07K16/24 ,  C07K16/28 ,  A61P37/04 ,  A61P35/00 ,  G01N33/574

摘要： The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the antibodies or antigen-binding portion thereof. The disclosure also relates to methods for detecting IL-27 in, for example, a subject or a sample.

公开(公告)号：US20210115127A1

公开(公告)日：2021-04-22

申请号：US17033469

申请日：2020-09-25

申请人： Surface Oncology, Inc.

发明人： Jamie STRAND ,  Jonathan HILL ,  Devan MOODLEY

IPC分类号： C07K16/24 ,  A61P35/00 ,  C07K16/28

摘要： The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the antibodies or antigen-binding portion thereof. The disclosure also relates to methods for detecting IL-27 in, for example, a subject or a sample.

公开(公告)号：US20220389089A1

公开(公告)日：2022-12-08

申请号：US17738927

申请日：2022-05-06

申请人： Surface Oncology, Inc.

发明人： Alison O'NEILL ,  Lauren HARSHMAN ,  Jonathan HILL ,  Jou-Ku CHUNG ,  Kerry WHITE ,  Robert ROSS ,  Benjamin LEE

IPC分类号： C07K16/24 ,  A61P35/00

摘要： The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the antibodies or antigen-binding portion thereof at a dose of at least about 0.003 mg/kg to at least about 20 mg/kg.

公开(公告)号：US20200291114A1

公开(公告)日：2020-09-17

申请号：US16744733

申请日：2020-01-16

申请人： Erasmus University Medical Center ,  Surface Oncology, Inc.

发明人： Frank GROSVELD ,  Scott CHAPPEL ,  Jonathan HILL ,  Pamela M. HOLLAND ,  Andrew LAKE ,  Alison PATERSON

IPC分类号： C07K16/28

摘要： Disclosed herein are anti-CD47 antibody molecules, their manufacture and use in treating disorders associated with CD47 expression, for example, certain hematological cancers and solid tumors.