公开(公告)号：US20080242663A1

公开(公告)日：2008-10-02

申请号：US12039030

申请日：2008-02-28

申请人： Susan Elizabeth Ashton ,  Darren Anthony Edward Cross ,  Simon John East ,  Jason Grant Kettle ,  Mark Andrew Pearson ,  Stephen Robert Wedge ,  Bernard Christophe Barlaam ,  Richard Ducray ,  Stuart Charles Purkiss

发明人： Susan Elizabeth Ashton ,  Darren Anthony Edward Cross ,  Simon John East ,  Jason Grant Kettle ,  Mark Andrew Pearson ,  Stephen Robert Wedge ,  Bernard Christophe Barlaam ,  Richard Ducray ,  Stuart Charles Purkiss

IPC分类号： A61K31/5377 ,  C07D413/14 ,  A61P35/04

CPC分类号： C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

摘要： The invention concerns compounds of Formula I, or a pharmaceutically acceptable salt thereof, where R1, n, R2, R3, and R4 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of EphB4 kinases.

摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 3和R 3， ^{4 如说明书中所定义的。 本发明还涉及制备这些化合物的方法，含有它们的药物组合物及其在制备用于预防或治疗对抑制敏感的肿瘤或其它增殖性病症中的抗增殖剂的药物中的用途 的EphB4激酶。}