公开(公告)号：US10059704B2

公开(公告)日：2018-08-28

申请号：US14112864

申请日：2012-04-20

申请人： Sylvain Routier ,  Franck Suzenet ,  Frederic Pin ,  Sylvie Chalon ,  Johnny Vercouillie ,  Denis Guilloteau

发明人： Sylvain Routier ,  Franck Suzenet ,  Frederic Pin ,  Sylvie Chalon ,  Johnny Vercouillie ,  Denis Guilloteau

IPC分类号： C07D451/04 ,  A61K51/04 ,  C07D453/02 ,  C07D455/02

CPC分类号： C07D451/04 ,  A61K51/0453 ,  A61K51/0455 ,  A61K51/0459 ,  A61K51/0463 ,  C07D453/02 ,  C07D455/02 ,  G01N2333/70571 ,  G01N2800/28 ,  G01N2800/2821

摘要： A compound having the following general formula (I): wherein: X is a nitrogen atom and Y is a carbon atom; or X is a carbon atom and Y is a nitrogen atom; the Ar group is an aryl or heteroaryl group; and the RN and RN′ groups, together with the carbon atoms to which they are bound, form a monocyclic or bicyclic azacycloalkane group. The pharmaceutically acceptable salts thereof, the hydrates or polymorphic crystalline structures thereof, and to the racemates, diastereoisomers, or enantiomers thereof are also described.

公开(公告)号：US20140030191A1

公开(公告)日：2014-01-30

申请号：US14112864

申请日：2012-04-20

申请人： Sylvain Routier ,  Franck Suzenet ,  Frederic Pin ,  Sylvie Chalon ,  Johnny Vercouillie ,  Denis Guilloteau

发明人： Sylvain Routier ,  Franck Suzenet ,  Frederic Pin ,  Sylvie Chalon ,  Johnny Vercouillie ,  Denis Guilloteau

IPC分类号： C07D451/04 ,  C07D453/02 ,  A61K51/04

CPC分类号： C07D451/04 ,  A61K51/0453 ,  A61K51/0455 ,  A61K51/0459 ,  A61K51/0463 ,  C07D453/02 ,  C07D455/02 ,  G01N2333/70571 ,  G01N2800/28 ,  G01N2800/2821

摘要： A compound having the following general formula (I): wherein: X is a nitrogen atom and Y is a carbon atom; or X is a carbon atom and Y is a nitrogen atom; the Ar group is an aryl or heteroaryl group; and the RN and RN′ groups, together with the carbon atoms to which they are bound, form a monocyclic or bicyclic azacycloalkane group. The pharmaceutically acceptable salts thereof, the hydrates or polymorphic crystalline structures thereof, and to the racemates, diastereoisomers, or enantiomers thereof are also described.

摘要翻译： 具有以下通式（I）的化合物：其中：X是氮原子，Y是碳原子; 或X为碳原子，Y为氮原子; Ar基团是芳基或杂芳基; 并且RN和RN'基团与它们所结合的碳原子一起形成单环或双环氮杂环烷基。 还描述了其药学上可接受的盐，其水合物或多晶型结构以及其外消旋物，非对映异构体或其对映异构体。

公开(公告)号：US20090274674A1

公开(公告)日：2009-11-05

申请号：US12086785

申请日：2006-12-19

申请人： Franck Suzenet ,  Gerald Guillaumet ,  Christelle Pillard ,  Carine Bassene ,  Catherine Dacquet ,  Alain Ktorza ,  Daniel-Henri Caignard

发明人： Franck Suzenet ,  Gerald Guillaumet ,  Christelle Pillard ,  Carine Bassene ,  Catherine Dacquet ,  Alain Ktorza ,  Daniel-Henri Caignard

IPC分类号： A61K31/122 ,  C07D471/04 ,  A61K31/437 ,  A61P3/04

CPC分类号： C07D471/04

摘要： Compounds of formula (I): wherein: X represents a hydrogen or halogen atom or an alkyl group, R1, R2, R3 and R4 are as defined in the description, A represents an alkylene chain as defined in the description, B represents an alkyl or alkenyl group substituted by a group D represents a pyridine nucleus.

摘要翻译： 式（I）化合物：其中：X表示氢或卤素原子或烷基，R 1，R 2，R 3和R 4如说明书中所定义，A表示如说明书中所定义的亚烷基链，B表示烷基 或被基团D取代的链烯基表示吡啶核。