PROCESS FOR THE PRODUCTION OF AMIDES
    1.
    发明申请
    PROCESS FOR THE PRODUCTION OF AMIDES 有权
    生产助剂的方法

    公开(公告)号:US20130253225A1

    公开(公告)日:2013-09-26

    申请号:US13889041

    申请日:2013-05-07

    摘要: The present invention relates to a process for the preparation of compounds of formula I wherein R1 and R2 are each independently of the other hydrogen or C1-C5alkyl and R3 is CF3 or CF2H, by a) reaction of a compound of formula II wherein R1 and R2 are as defined for formula I, with at least one reducing agent to form a compound of formula III wherein R1 and R2 are as defined for formula I, and b) reaction of that compound with at least one reducing agent to form a compound of formula IV wherein R1 and R2 are as defined for formula I, and (c) reaction of that compound with a compound of formula V wherein Q is chlorine, fluorine, bromine, iodine, hydroxy or C1-C6alkoxy and R3 is as defined for formula I, to form the compound of formula I; and to novel intermediates for use in that process.

    摘要翻译: 本发明涉及一种制备式Ⅰ化合物的方法,其中R1和R2分别独立地为氢或C1-C5烷基,R3为CF3或CF2H,通过a)式II化合物的反应其中R 1和 R 2如式I所定义,与至少一种还原剂形成式III化合物,其中R 1和R 2如式I所定义,和b)该化合物与至少一种还原剂的反应形成式 式IV其中R1和R2如式I所定义,和(c)该化合物与式V化合物的反应,其中Q是氯,氟,溴,碘,羟基或C 1 -C 6烷氧基,R 3如式 I,形成式I化合物; 以及用于该过程的新型中间体。

    Process for the production of amides
    2.
    发明授权
    Process for the production of amides 有权
    酰胺生产工艺

    公开(公告)号:US08680337B2

    公开(公告)日:2014-03-25

    申请号:US13889041

    申请日:2013-05-07

    IPC分类号: C07C211/61 C07C205/06

    摘要: The present invention relates to a process for the preparation of compounds of formula I wherein R1 and R2 are each independently of the other hydrogen or C1-C5alkyl and R3 is CF3 or CF2H, by a) reaction of a compound of formula II wherein R1 and R2 are as defined for formula I, with at least one reducing agent to form a compound of formula III wherein R1 and R2 are as defined for formula I, and b) reaction of that compound with at least one reducing agent to form a compound of formula IV wherein R1 and R2 are as defined for formula I, and (c) reaction of that compound with a compound of formula V wherein Q is chlorine, fluorine, bromine, iodine, hydroxy or C1-C6alkoxy and R3 is as defined for formula I, to form the compound of formula I; and to novel intermediates for use in that process.

    摘要翻译: 本发明涉及一种制备式Ⅰ化合物的方法,其中R1和R2分别独立地为氢或C1-C5烷基,R3为CF3或CF2H,通过a)式II化合物的反应其中R 1和 R 2如式I所定义,与至少一种还原剂形成式III化合物,其中R 1和R 2如式I所定义,和b)该化合物与至少一种还原剂的反应形成式 式IV其中R1和R2如式I所定义,和(c)该化合物与式V化合物的反应,其中Q是氯,氟,溴,碘,羟基或C 1 -C 6烷氧基,R 3如式 I,形成式I化合物; 以及用于该过程的新型中间体。