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公开(公告)号：US11124527B2
公开(公告)日：2021-09-21
申请号：US15579830
申请日：2016-06-03
申请人： Syros Pharmaceuticals, Inc. , Christopher Roberts , Yi Zhang , Francis Beaumier , Luce Lépissier
发明人： Jason J. Marineau , Peter B. Rahl , Kevin Sprott , Stephane Ciblat , Boubacar Sow , Robin Larouche-Gauthier , Lauren Berstler , Christopher Roberts , Yi Zhang , Francis Beaumier , Luce Lépissier
IPC分类号： C07D513/04 , A61P35/00 , C07D495/04
摘要： The present invention provides novel compounds of Formulas (I) and (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angio genesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.
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公开(公告)号：US20180162851A1
公开(公告)日：2018-06-14
申请号：US15579833
申请日：2016-06-05
申请人： Christopher Roberts , Yi Zhang , Francis Beaumier , Luce Lépissier , Syros Pharmaceuticals, Inc.
发明人： Jason J. Marineau , Peter B. Rahl , Kevin Sprott , Stephane Ciblat , Boubacar Sow , Robin Larouche-Gauthier , Lauren Berstler , Christopher Roberts , Yi Zhang , Francis Beaumier , Luce Lépissier
IPC分类号： C07D417/04 , C07D417/14 , C07D495/04 , C07D513/02 , A61P35/00
CPC分类号： C07D417/04 , A61P35/00 , C07D417/14 , C07D495/04 , C07D513/02
摘要： The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angio genesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.
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公开(公告)号：US10787444B2
公开(公告)日：2020-09-29
申请号：US15579833
申请日：2016-06-05
申请人： Syros Pharmaceuticals, Inc. , Christopher Roberts , Yi Zhang , Francis Beaumier , Luce Lépissier
发明人： Jason J. Marineau , Peter B. Rahl , Kevin Sprott , Stephane Ciblat , Boubacar Sow , Robin Larouche-Gauthier , Lauren Berstler , Christopher Roberts , Yi Zhang , Francis Beaumier , Luce Lépissier
IPC分类号： C07D417/04 , C07D417/14 , C07D495/04 , C07D513/02 , A61P35/00
摘要： The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angio genesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.
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公开(公告)号：US20180354972A1
公开(公告)日：2018-12-13
申请号：US15579830
申请日：2016-06-03
申请人： Christopher Roberts , Yi Zhang , Francis Beaumier , Luce Lépissier , Syros Pharmaceuticals, Inc.
发明人： Jason J. Marineau , Peter B. Rahl , Kevin Sprott , Stephane Ciblat , Boubacar Sow , Robin Larouche-Gauthier , Lauren Berstler , Christopher Roberts , Zhang Yi , Francis Beaumier , Luce Lépissier
IPC分类号： C07D513/04 , C07D495/04 , A61P35/00
CPC分类号： C07D513/04 , A61P35/00 , C07D495/04
摘要： The present invention provides novel compounds of Formulas (I) and (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angio genesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.
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公开(公告)号：US11753418B2
公开(公告)日：2023-09-12
申请号：US17411965
申请日：2021-08-25
发明人： Jason J. Marineau , Peter B. Rahl , Kevin Sprott , Stephane Ciblat , Boubacar Sow , Robin Larouche-Gauthier , Lauren Berstler , Christopher Roberts , Yi Zhang , Francis Beaumier , Luce Lépissier
IPC分类号： C07D513/04 , A61P35/00 , C07D495/04
CPC分类号： C07D513/04 , A61P35/00 , C07D495/04
摘要： The present invention provides novel compounds of Formulas (I) and (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angio genesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.
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公开(公告)号：US11274103B2
公开(公告)日：2022-03-15
申请号：US15699176
申请日：2017-09-08
发明人： Jason J. Marineau , Kevin Sprott , Stephane Ciblat , Christopher Roberts , Yi Zhang , Francis Beaumier , Luce Lépissier , Boubacar Sow , Peter B. Rahi , Robin Larouche-Gauthier , Lauren Berstler
IPC分类号： C07D495/04 , A61P35/00
摘要： The present invention provides novel compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angiogenesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.
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公开(公告)号：US20210221820A1
公开(公告)日：2021-07-22
申请号：US17107762
申请日：2020-11-30
发明人： Jason J. Marineau , Kevin Sprott , Stephane Ciblat , Christopher Roberts , Yi Zhang , Francis Beaumier , Luce Lépissier , Boubacar Sow , Peter B. Rahl , Robin Larouche-Gauther , Lauren Berstler
IPC分类号： C07D495/04 , A61P35/00
摘要： The present invention provides novel compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angiogenesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.
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公开(公告)号：US20230144106A1
公开(公告)日：2023-05-11
申请号：US17864133
申请日：2022-07-13
发明人： Jason J. Marineau , Peter B. Rahl , Kevin Sprott , Stephane Ciblat , Boubacar Sow , Robin Larouche-Gauthier , Lauren Berstler , Christopher Roberts , Yi Zhang , Francis Beaumier , Luce Lépissier
IPC分类号： C07D417/04 , C07D417/14 , C07D495/04 , C07D513/02 , A61P35/00
CPC分类号： C07D417/04 , C07D417/14 , C07D495/04 , C07D513/02 , A61P35/00
摘要： The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angiogenesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.
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公开(公告)号：US20210188833A1
公开(公告)日：2021-06-24
申请号：US16913230
申请日：2020-06-26
发明人： Jason J. Marineau , Peter B. Rahl , Kevin Sprott , Stephane Ciblat , Boubacar Sow , Robin Larouche-Gauthier , Lauren Berstler , Christopher Roberts , Yi Zhang , Francis Beaumier , Luce Lépissier
IPC分类号： C07D417/04 , C07D417/14 , C07D495/04 , C07D513/02 , A61P35/00
摘要： The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angiogenesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.
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公开(公告)号：US20190048019A1
公开(公告)日：2019-02-14
申请号：US15699176
申请日：2017-09-08
发明人： Jason J. Marineau , Kevin Sprott , Stephane Ciblat , Christopher Roberts , Yi Zhang , Francis Beaumier , Luce Lépissier , Boubacar Sow , Peter B. Rahl , Robin Larouche-Gauther , Lauren Berstler
IPC分类号： C07D495/04 , A61P35/00
摘要： The present invention provides novel compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angiogenesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.
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