公开(公告)号：US20110293555A1

公开(公告)日：2011-12-01

申请号：US13205053

申请日：2011-08-08

申请人： TADANORI MAYUMI ,  YASUO TSUTSUMI ,  SHINSAKU NAKAGAWA ,  TSUNETAKA OHTA

发明人： TADANORI MAYUMI ,  YASUO TSUTSUMI ,  SHINSAKU NAKAGAWA ,  TSUNETAKA OHTA

IPC分类号： A61K38/19 ,  A61P31/00 ,  C07K14/525

CPC分类号： A61K38/191 ,  C07K14/525 ,  Y02A50/411

摘要： The present invention has an object to provide a tumor necrosis factor mutant protein, particularly, a tumor necrosis factor mutant protein specific to TNF-R1 or TNF-R2; tumor necrosis factor inhibitor; or tumor necrosis factor preparation containing it as an effective ingredient, and the object is solved by providing a tumor necrosis factor mutant protein where one or more amino acid residues selected from the group consisting of 29th, 31st, 32nd, 145th, 146th and 147th, or the group consisting of 84th to 89th from the N-terminal of the amino acid sequence of SEQ ID NO:1 is/are replaced with other amino acid residue(s); a tumor necrosis factor inhibitor; and a tumor necrosis factor preparation containing it as an effective ingredient.

摘要翻译： 本发明的目的是提供肿瘤坏死因子突变蛋白，特别是TNF-R1或TNF-R2特异的肿瘤坏死因子突变体蛋白; 肿瘤坏死因子抑制剂; 或含有其作为有效成分的肿瘤坏死因子制剂，其目的是通过提供一种或多种选自第29,31,32,35,146和147位的氨基酸残基的肿瘤坏死因子突变蛋白来解决， 或由SEQ ID NO：1的氨基酸序列的N末端第84位至第89位的基团被其它氨基酸残基取代; 肿瘤坏死因子抑制剂; 和含有它作为有效成分的肿瘤坏死因子制剂。