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    5H-pyrrolo[2,3-D]pyrimidin-6(7H)-one derivative
    2.
    发明授权
    5H-pyrrolo[2,3-D]pyrimidin-6(7H)-one derivative 有权

    公开(公告)号：US10538528B2

    公开(公告)日：2020-01-21

    申请号：US16302829

    申请日：2017-05-19

    申请人： Taiho Pharmaceutical Co., Ltd.

    发明人： Tetsuya Sugimoto ,  Toshihiro Sakamoto ,  Fuyuki Yamamoto ,  Yu Kobayakawa ,  Naoki Egashira ,  Koji Ichikawa ,  Takumitsu Machida

    IPC分类号： C07D487/04 ,  A61P35/00 ,  A61K31/519

    摘要： The invention of the present application provides a compound represented by Formula (I) or a salt thereof, which exhibits an inhibitory activity against at least one kinase selected from the group consisting of Akt kinase, Rsk kinase, and S6K kinase and/or a cell proliferation inhibiting effect and is useful as a prophylactic and/or therapeutic agent for diseases associated with the above-mentioned kinases, particularly cancer. [In the formula, R1 represents a 4- to 6-membered monocyclic unsaturated heterocyclic group which has 1 to 3 hetero atoms independently selected from N, S and O and may have a substituent; R2 represents a hydrogen atom or the like; R3, R4, and R5, may be the same as or different from one another and independently represent a hydrogen atom or the like; R6 represents a hydrogen atom or the like; R7 and R8, may be the same as or different from each other and independently represent a hydrogen atom or the like; X1 and X2 may be the same as or different from each other and independently represent N or CR9; R9 represents a hydrogen atom or the like; and X3 represents N or CH when the broken line () represents a single bond, and represents C when a broken line indicates a double bond, wherein at least one of X1 or X2 represents N.]