公开(公告)号：US20160039811A1

公开(公告)日：2016-02-11

申请号：US14779347

申请日：2014-03-27

Applicant: TAKEDA PHARMACETICAL COMPANY LIMITED

Inventor： Masato YOSHIDA ,  Hiroyuki NAGAMIYA ,  Yusuke OHBA ,  Masaki SETO ,  Takatoshi YOGO ,  Satoshi SASAKI ,  Norihito TOKUNAGA ,  Kazuyoshi ASO

IPC: C07D471/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: Provided is a compound or a salt thereof, which has an excellent JAK inhibitory action, and is useful as a prophylactic or therapeutic agent for autoimmune diseases (rheumatoid arthritis, psoriasis, inflammatory bowel disease, Sjogren's syndrome, Behcet's syndrome, multiple sclerosis, systemic lupus erythematosus, etc.), cancer (leukemia, uterine leiomyosarcoma, prostate cancer, multiple myeloma, cachexia, myelofibrosis, etc.) and the like. The present invention relates to a compound represented by the formula (I) wherein each symbol is as defined in the present specification, or a salt thereof.

Abstract translation: 提供具有优异的JAK抑制作用的化合物或其盐，并且可用作自身免疫性疾病（类风湿性关节炎，牛皮癣，炎性肠病，干燥综合征，白塞氏综合征，多发性硬化症，系统性狼疮）的预防或治疗剂 红斑狼疮等），癌症（白血病，子宫平滑肌肉瘤，前列腺癌，多发性骨髓瘤，恶病质，骨髓纤维化等）等。 本发明涉及由式（I）表示的化合物，其中每个符号如本说明书中所定义，或其盐。