公开(公告)号：US12054474B2

公开(公告)日：2024-08-06

申请号：US17962781

申请日：2022-10-10

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Colm Carroll ,  Anne Goldby ,  Martin Teall

IPC: A61K31/454 ,  A61K31/4545 ,  A61K45/06 ,  C07D211/96 ,  C07D401/12 ,  C07D401/14

CPC classification number: C07D401/12 ,  A61K31/454 ,  A61K31/4545 ,  A61K45/06 ,  C07D211/96 ,  C07D401/14

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof.




in which q, R11, R12, R13 and R14 are as defined in the specification, for use in therapy.

公开(公告)号：US11512066B2

公开(公告)日：2022-11-29

申请号：US16707079

申请日：2019-12-09

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Colm Carroll ,  Anne Goldby ,  Martin Teall

IPC: C07D401/12 ,  A61K31/454 ,  A61K31/4545 ,  A61K45/06 ,  C07D211/96 ,  C07D401/14

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof in which q, R11, R12, R13 and R14 are as defined in the specification, for use in therapy.

公开(公告)号：US10544126B2

公开(公告)日：2020-01-28

申请号：US16194762

申请日：2018-11-19

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Colm Carroll ,  Anne Goldby ,  Martin Teall

IPC: C07D401/12 ,  A61K31/454 ,  A61K31/4545 ,  A61K45/06 ,  C07D211/96 ,  C07D401/14

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof in which q, R11, R12, R13 and R14 are as defined in the specification, for use in therapy.

公开(公告)号：US10167273B2

公开(公告)日：2019-01-01

申请号：US15262436

申请日：2016-09-12

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Colm Carroll ,  Anne Goldby ,  Martin Teall

IPC: C07D401/12 ,  A61K31/454 ,  A61K31/4545 ,  A61K45/06 ,  C07D211/96 ,  C07D401/14

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof in which q, R11, R12, R13 and R14 are as defined in the specification, for use in therapy.

公开(公告)号：US20190084962A1

公开(公告)日：2019-03-21

申请号：US16194762

申请日：2018-11-19

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Colm Carroll ,  Anne Goldby ,  Martin Teall

IPC: C07D401/12 ,  C07D211/96 ,  A61K45/06 ,  A61K31/454 ,  C07D401/14 ,  A61K31/4545

CPC classification number: C07D401/12 ,  A61K31/454 ,  A61K31/4545 ,  A61K45/06 ,  C07D211/96 ,  C07D401/14

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof in which q, R11, R12, R13 and R14 are as defined in the specification, for use in therapy.

公开(公告)号：US20150111922A1

公开(公告)日：2015-04-23

申请号：US14402751

申请日：2013-05-29

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Colm Carroll ,  Anne Goldby ,  Martin Teall

IPC: C07D401/14 ,  C07D401/12

CPC classification number: C07D401/12 ,  A61K31/454 ,  A61K31/4545 ,  A61K45/06 ,  C07D211/96 ,  C07D401/14

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof: (I) in which m, n, W, X, Y, Z, R1, R2, R3 and R4 are as defined in the specification, for use in the treatment or prevention of a diseases o conition mediated by a prokineticin, such as psychiatric and neurological conditions.

Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐：（I）其中m，n，w，X，Y，Z，R 1，R 2，R 3和R 4如本说明书中所定义， 治疗或预防由促运动素介导的疾病，如精神病学和神经病学疾病。

公开(公告)号：US20130324576A1

公开(公告)日：2013-12-05

申请号：US13904198

申请日：2013-05-29

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Colm Carroll ,  Anne Goldby ,  Martin Teall

IPC: C07D401/14 ,  C07D401/12 ,  A61K31/4545 ,  C07D211/96 ,  A61K45/06 ,  A61K31/454

CPC classification number: C07D401/12 ,  A61K31/454 ,  A61K31/4545 ,  A61K45/06 ,  C07D211/96 ,  C07D401/14

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof in which m, n, W, X, Y, Z, R, R1, R2, R3 and R4 are as defined in the specification, for use in therapy.

Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐，其中m，n，w，X，Y，Z，R，R 1，R 2，R 3和R 4如本说明书中所定义，用于治疗。

公开(公告)号：US20230073334A1

公开(公告)日：2023-03-09

申请号：US17962781

申请日：2022-10-10

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Colm Carroll ,  Anne Goldby ,  Martin Teall

IPC: C07D401/12 ,  A61K31/454 ,  A61K31/4545 ,  A61K45/06 ,  C07D211/96 ,  C07D401/14

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. in which q, R11, R12, R13 and R14 are as defined in the specification, for use in therapy.

公开(公告)号：US20160376256A1

公开(公告)日：2016-12-29

申请号：US15262436

申请日：2016-09-12

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Colm Carroll ,  Anne Goldby ,  Martin Teall

IPC: C07D401/12 ,  C07D401/14 ,  A61K31/4545 ,  A61K31/454

CPC classification number: C07D401/12 ,  A61K31/454 ,  A61K31/4545 ,  A61K45/06 ,  C07D211/96 ,  C07D401/14

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof in which q, R11, R12, R13 and R14 are as defined in the specification, for use in therapy.

Abstract translation: 其中q，R11，R12，R13和R14如说明书中所定义，用于治疗。

公开(公告)号：US09475795B2

公开(公告)日：2016-10-25

申请号：US14402751

申请日：2013-05-29

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Colm Carroll ,  Anne Goldby ,  Martin Teall

IPC: C07D401/12 ,  C07D401/14 ,  A61K31/454 ,  A61K31/4545 ,  A61K45/06 ,  C07D211/96

CPC classification number: C07D401/12 ,  A61K31/454 ,  A61K31/4545 ,  A61K45/06 ,  C07D211/96 ,  C07D401/14

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof: (I) in which m, n, W, X, Y, Z, R1, R2, R3 and R4 are as defined in the specification, for use in the treatment or prevention of a diseases o conition mediated by a prokineticin, such as psychiatric and neurological conditions.

Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐：（I）其中m，n，w，X，Y，Z，R 1，R 2，R 3和R 4如本说明书中所定义， 治疗或预防由促运动素介导的疾病，如精神病学和神经病学疾病。