公开(公告)号：US20170121286A1

公开(公告)日：2017-05-04

申请号：US15301525

申请日：2015-04-09

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Hironori YAMASHITA ,  Kazuhiro MIWA

IPC: C07D211/60 ,  C07C231/02 ,  C07D401/06

CPC classification number: C07D211/60 ,  C07C231/02 ,  C07C231/08 ,  C07C2101/02 ,  C07C2101/08 ,  C07C2101/16 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07D401/06 ,  C07C233/58

Abstract: Provided is a production method of a synthetic intermediate for a heterocyclic compound having a renin inhibitory activity and useful as a prophylactic or therapeutic drug for diabetic nephropathy, hypertension and the like. A production method of a compound represented by the formula (III-1a), the formula (III-1b), the formula (III-1c) and/or the formula (III-1d); wherein each symbol is as described in DESCRIPTION, or a salt thereof, including reacting a compound represented by the formula (Ia) or (Ib): wherein each symbol is as described in DESCRIPTION, or a salt thereof with a compound represented by the formula (II): wherein each symbol is as described in DESCRIPTION, or a salt thereof, in the presence of an aluminum compound and a chiral amine compound.